Cell kinetics and repopulation mechanisms during multifraction irradiation of spheroids

Radiotherapy and Oncology

Volumn 46, Issue 2, 1998, Pages 201-207

  Sham, Edward ^a   Durand, Ralph E ^b  

^a Vancouver Cancer Centre   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

Cell kinetics; Irradiation; Predictive assay; Repopulation

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL PROLIFERATION; CELL REGENERATION; CHINESE HAMSTER; CLONOGENESIS; DOSE RESPONSE; FLOW CYTOMETRY; IRRADIATION; LUNG ALVEOLUS CELL; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE;

ANIMALS; CELL CYCLE; CELL DIVISION; CRICETINAE; CRICETULUS; FLOW CYTOMETRY; LUNG; PREDICTIVE VALUE OF TESTS; SPHEROIDS, CELLULAR;

EID: 0031936690     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(97)00193-X     Document Type: Article

References (21)

1. Acker, H., Carlsson, J., Durand, R.E. and Sutherland, R.M. Spheroids in Cancer Research. Springer-Verlag, Berlin, 1984.
2. pot correlation. Semin. Radiat. Oncol. 2: 62-66, 1992.
3. Begg, A.C., Hofland, I. and Kummermehr, J. Tumour cell repopulation during fractionated radiotherapy: correlation between flow cytometric and radiobiological data in three murine tumours. Eur. J. Cancer 27: 537-543, 1991.
4. Begg, A.C. Prediction of repopulation rates and radiosensitivity in human tumours. Int. J. Radiat. Biol. 65: 103-108, 1994.
5. pot! Int. J. Radiat. Oncol. Biol. Phys. 32: 1539-1541, 1995.
6. Begg, A.C., Hofland, I., Van Glabekke, M., Bartelink, H. and Horiot, J.C. Predictive value of potential doubling time for radiotherapy of head and neck tumor patients: results from the EORTC cooperative trial 22851. Semin. Radiat. Oncol. 2: 22-25, 1992.
7. Begg, A.C., McNally, N.J., Shrieve, D.C. and Karcher, H. A method to measure the duration of DNA synthesis and the potential doubling time from a single sample. Cytometry 6: 620-626, 1985.
8. Carlsson, J. and Nederman, T. Tumour spheroid technology in cancer therapy research. Eur. J. Cancer Clin. Oncol. 25: 1127-1133, 1989.
9. Durand, R.E. Cell cycle kinetics in an in vitro tumor model. Cell Tissue Kinet. 9: 403-412, 1976.
10. pot in heterogeneous systems: a new approach illustrated with multicell spheroids. Cytometry 14: 527-534, 1993.
11. Durand, R.E. and Sutherland, R.M. Effects of intercellular contact on repair of radiation damage. Exp. Cell Res. 71: 75-80, 1972.
12. Fowler, J.F. Brief survey of radiobiological principles in fractionated radiotherapy. Semin. Radiat. Oncol. 2: 16-21, 1992.
13. Mueller-Klieser, W. Multicellular spheroids. A review on cellular aggregates in cancer research. J. Cancer Res. Clin. Oncol. 113: 101-122, 1987.
14. Olive, P.L., Leonard, J.C. and Durand, R.E. Development of tetraploidy in V79 spheroids. In Vitro 18: 708-714, 1982.
15. pot. Int. J. Radiat. Oncol. Biol. Phys. 31: 847-856, 1995.
16. Steel, G.G. Growth Kinetics of Tumors. Oxford University Press, Oxford, 1977.
17. Sutherland, R.M. Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 240: 177-184, 1988.
18. Sutherland, R.M. and Durand, R.E. Radiation response of multicell spheroids - an in vitro tumour model. Curr. Topics Radiat. Res. Q. 11: 87-139, 1976.
19. pot in cancer of the uterine cervix: correlation between two laboratories and preliminary clinical results. Int. J. Radiat. Oncol. Biol. Phys. 32: 1319-1329, 1995.
20. White, R.A. and Terry, N.H.A. A quantitative method for evaluating bivariate flow cytometric data obtained using monoclonal antibodies to bromodeoxyuridine. Cytometry 13: 490-495, 1992.
21. Withers, H.R., Taylor, J.M.G. and Maciejewski, B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol. 27: 131-146, 1988.