Serum α2-macroglobulin and α1-inhibitor 3 concentrations are increased in hypoalbuminemia by post-transcriptional mechanisms

Kidney International

Volumn 53, Issue 1, 1998, Pages 67-75

  Stevenson, Frazier T ^b   Greene, Stephanie ^b   Kaysen, George A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

Analbuminemia; Fractional catabolic rate; Nephrotic syndrome; Protease inhibitors; Protein synthesis

Indexed keywords

ALPHA 2 MACROGLOBULIN; ALPHA1 PROTEINASE INHIBITOR III; MESSENGER RNA;

ANALBUMINEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HEYMANN NEPHRITIS; HYPOALBUMINEMIA; MALE; NEPHROTIC SYNDROME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN SYNTHESIS REGULATION; RAT; RNA ANALYSIS; TRANSCRIPTION REGULATION;

EID: 0031936315     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00734.x     Document Type: Article

References (64)

1. DEEN WM, BRIDGES CR, BRENNER BM, MYERS BD: Heteroporous model of glomerular size selectivity: Application to normal and nephrotic humans. Am J Physiol 249:F374-F389, 1985
2. GITLIN D, JANEWAY CA, FARR LE: Studies on the metabolism of plasma proteins in nephrotic syndrome. I. Albumin, gamma-globulin and iron-binding globulin. J Clin Invest 35:44-55, 1956
3. BALDAMUS CA, GALASKE R, EISENBACH GM, KRAUSE HP, STOLTE H: Glomerular protein filtration in normal and nephrotic rats: A micropuncture study. Contr Nephrol 1:37-49, 1975
4. KAYSEN GA, KIRKPATRICK WG, COUSER WG Albumin homeostasis in the nephrotic rat: Nutritional considerations. Am J Physiol 247:F192-F202, 1984
5. KAYSEN GA, JONES H JR, MARTIN V, HUTCHISON FN: A low-protein diet restricts albumin synthesis in nephrotic rats. J Clin Invest 83:1623-1629, 1989
6. KAYSEN GA, HOYE E, JONES H JR: Apolipoprotein AI levels are increased in part as a consequence of reduced catabolism in nephrotic rats. Am J Physiol 268:F532-F540, 1995
7. GIROT R, JAUBERT F, LEON M, BELLON B, AIACH M, JOSSO F, LEPELLETIER O, BEGUIN S, MONNET JP: Albumin, fibrinogen prothrombin, and antithrombin III variations in blood, urines and liver in rat nephrotic syndrome (Heymann nephritis). Thromb Haemostas 49:13-17, 1983
8. JENSEN H, BRO-JORGENSEN K, JARNUM S, OLESEN H, YSSING M: Transferrin metabolism in the nephrotic syndrome and in protein-losing gastroenteropathy. Scand J Clin Lab Invest 21:293-304, 1968
9. KAYSEN GA, SUN X, JONES H JR, MARTIN VI, JOLES JA, TSUKAMOTO H, COUSER WG, AL-BANDER H: Non-iron mediated alteration in hepatic transferrin gene expression in the nephrotic rat. Kidney Int 47:1068-1077, 1995
10. PEDRAZA-CHAVERRI J, TORRES-RODRIGUEZ GA, CRUZ C, MAINERO A, TAPIA E, IBARRA-RUBIO ME, SILENCIO JL: Copper and zinc metabolism in aminonucleoside-induced nephrotic syndrome. Nephron 66:87-92, 1994
11. STEC J, PODRACKA L, PAVKOVCEKOVA O, KOLLAR J: Zinc and copper metabolism in nephrotic syndrome. Nephron 56:186-187, 1990
12. CARTWRIGHT GE, GUBLER CJ, WINTROBE MM: Studies on copper metabolism: Copper and iron metabolism in the nephrotic syndrome. J Clin Invest 33:685-698, 1954
13. AL-BANDER HA, MARTIN VI, KAYSEN GA: Plasma IgG pool is not defended from urinary loss in nephrotic syndrome. Am J Physiol 262:F333-F337, 1992
14. KAYSEN GA: Plasma composition in the nephrotic syndrome. Am J Nephrol 13:347-359, 1993
15. KAYSEN GA, HOYE E, JONES H JR, VAN TOL A, JOLES JA: Effect of oncotic pressure on apolipoprotein A-I metabolism in the rat. Am J Kidney Dis 26:178-186, 1995
16. SUN X, JONES H JR, JOLES JA, VAN TOL A, KAYSEN GA: Apolipoprotein gene expression in analbuminemic rats and in rats with Heymann nephritis. Am J Physiol 262:F755-F761, 1992
17. SUN X, MARTIN V, WEISS RH, KAYSEN GA: Selective transcriptional augmentation of hepatic gene expression in the rat with Heymann nephritis. Am J Physiol 264:F441-F447, 1993
18. YAMAUCHI A, IMAI E, NOGUCHI T, TANAKA T, YAMAMOTO S, MIKAMI H, FUKUHARA Y, FUJII M, ORITA Y, KAMADA T: Albumin gene transcription is enhanced in liver of nephrotic rats. Am J Physiol 254:E676-E679, 1988
19. KAYSEN GA, JONES H JR, HUTCHISON FN: High protein diets stimulate albumin synthesis in nephrotic rats at the site of albumin mRNA transcription. Kidney Int 27:S168-S172, 1989
20. OVERBERGH L, HILLIKER C, LORENT K, VAN LEUVEN F, VAN DEN BERGHE H: Identification of four genes coding for isoforms of murinoglobulin, the monomeric mouse alpha 2-macroglobulin: Characterization of the exons coding for the bait region. Genomics 22:530-539, 1994
21. IWASAKI H, SUZUKI Y, SINOHARA H: Cloning and sequencing of cDNAs encoding plasma alpha-macroglobulin and murinoglobulin from guinea pig: Implications for molecular evolution of alpha-macroglobulin family. J Biochem 120:1167-1175, 1996
22. HORN F, WEGENKA UM, LUTTICKEN C, YUAN J, ROEB E, BOERS W, BUSCHMANN J, HEINRICH PC: Regulation of alpha 2-macroglobulin gene expression by interleukin-6. Ann NY Acad Sci 737:308-323, 1994
23. SAAD B, FREI K, SCHOLL FA, FONTANA A, MAIER P: Hepatocyte-derived interleukin-6 and tumor-necrosis factor alpha mediate the lipopolysaccharide-induced acute-phase response and nitric oxide release by cultured rat hepatocytes. Eur J Biochem 229:349-355, 1995
24. LI AH, ZWAIN IH, PINEAU C, CAZZOLLA N, SASO L, SILVESTRINI B, BARDIN CW, CHENG CY: Response of alpha 2-macroglobulin messenger ribonucleic acid expression to acute inflammation in the testis is different from the response in the liver and brain. Biol Reproduct 50:1287-1296, 1994
25. WEGENKA UM, BUSCHMANN J, LUTTICKEN C, HEINRICH PC, HORN F: Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6at the posttranslational level. Molec Cell Biol 13:276-288, 1993
26. BRECHNER T, HOCKE G, GOEL A, FEY GH: Interleukin 6 response factor binds co-operatively at two adjacent sites in the promoter upstream region of the rat alpha 2-macroglobulin gene. Molec Biol Med 8:267-285, 1991
27. FEY GH, GAULDIE J: The acute phase response of the liver in inflammation. Progr Liver Dis 9:89-116, 1990
28. ABRAHAM LJ, BRADSHAW AD, FLETCHER RG, FEY GH: Interleukin 6 is a negative regulator of the acute phase alpha 1-inhibitor III gene. Molec Biol Med 7:261-271, 1990
29. ABRAHAM LJ, BRADSHAW AD, SHIELS BR, NORTHEMANN W, HUDSON G, FEY GH: Hepatic transcription of the acute-phase alpha 1-inhibitor III gene is controlled by a novel combination of cis-acting regulatory elements. Molec Cell Biol 10:3483-3491, 1990
30. WEBB DJ, WEN J, LYSIAK JJ, UMANS L, VAN LEUVEN F, GONIAS SL: Murine alpha-macroglobulins demonstrate divergent activities as neutralizers of transforming growth factor-beta and as inducers of nitric oxide synthesis. A possible mechanism for the endotoxin insensitivity of the alpha2-macroglobulin gene knock-out mouse. J Biol Chem 271:24982-24988, 1996
31. KURDOWSKA A, CARR FK, STEVENS MD, BAUGHMAN RP, MARTIN TR: Studies on the interaction of IL-8 with human plasma alpha 2-macroglobulin: Evidence for the presence of IL-8 complexed to alpha 2-macroglobulin in lung fluids of patients with adult respiratory distress syndrome. J Immunol 158:1930-1940, 1997
32. LYSIAK JJ, HUSSAINI IM, WEBB DJ, GLASS WF II, ALLIETTA M, GONIAS SL: Alpha 2-macroglobulin functions as a cytokine carrier to induce nitric oxide synthesis and cause nitric oxide-dependent cytotoxicity in the RAW 264.7 macrophage cell line. J Biol Chem 270: 21919-21927, 1995
33. DA SILVA GC, TEIXEIRA N, BELL SC: Major secretory product of the mesometrial decidua in the rat, a variant of alpha-2-macroglobulin, binds insulin-like growth factor I via a protease-dependent mechanism. Molec Reproduct Develop 44:103-110, 1996
34. STEFANSSON S, LAWRENCE DA, ARGRAVES WS: Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2. J Biol Chem 271:8215-8220, 1996
35. VALNICKOVA Z, THOGERSEN IB, CHRISTENSEN S, CHU CT, PIZZO SV, ENGHILD JJ: Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein. J Biol Chem 271:12937-12943, 1996
36. VAZIRI ND, GONZALES EC, SHAYESTEHFAR B, BARTON CH: Plasma levels and urinary excretion of fibrinolytic and protease inhibitory proteins in nephrotic syndrome. J Lab Clin Med 124:118-124, 1994
37. ASAMI T, NISHIHARA T, TOMISAWA S, SAKAI K, UCHIYAMA M: Study on proteinase-inhibiting capacity of plasma alpha 2-macroglobulin in idiopathic nephrotic syndrome. Nephron 72:512-517, 1996
38. KARKAR AM, REES AJ: Influence of an established acute phase response on the severity of experimental nephritis. Clin Exp Immunol 98:295-299, 1994
39. SAMBROOK J, FRITSCH EF, MANIATIS T: Molecular Cloning, A Laboratory Manual (2nd ed). Cold Spring Harbor, Cold Spring Harbor Laboratory Press, 1989
40. BERTANI T, POGGI A, POZZONI R, DELAINI F, SACCHI G, THOUA Y, MECCA G, REMUZZI G, DONATI B: Adriamycin-induced nephrotic syndrome in rats: Sequence of pathologic event. Lab Invest 46:16-23, 1982
41. ORLANDO RA, KERJASCHKI D, KURIHARA H, BIEMESDERFER D, FARQUHAR MG: gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex. PNAS USA 89:6698-6702, 1992
42. KAYSEN GA, WATSON JB: The mechanism of hypoalbuminemia in the 7/8 nephrectomized rat with chronic renal failure. Am J Physiol 243:F372-F378, 1982
43. KAYSEN GA, JONES H JR, JOLES JA; VAN TOL A: Effect of plasma oncotic pressure on apolipoprotein levels in rats with Heymann nephritis. Miner Electrolyte Metab 22:31-38, 1996
44. SRIVASTAVA RA, SRIVASTAVA N, SCHONFELD G: Expression of low density lipoprotein receptor, apolipoprotein AI, AII and AIV in various rat organs utilizing an efficient and rapid method for RNA isolation. Biochem Int 27:85-95, 1992
45. DAVIDSEN O, CHRISTENSEN EI, GLIEMANN J: The plasma clearance of human α2-macroglobulin-trypsin complex in the rat is mainly accounted for by uptake into hepatocytes. Biochim Biophys Acta 846: 85-92, 1985
46. KAYSEN GA, SCHOENFELD PY: Albumin homeostasis in patients undergoing continuous ambulatory peritoneal dialysis. Kidney Int 25:107-114, 1984
47. KATZ J, BONORRIS G, SELLERS AL: Albumin metabolism in aminonucleoside nephrotic rats. J Lab Clin Med 62:910-934, 1963
48. JENSEN H, ROSSING N, ANDERSON SB, JARNUM S: Albumin metabolism in the nephrotic syndrome in adults. Clin Sci 33:445-457, 1967
49. ESUMI H, SATO S, OKUI M, SUGIMURA T, NAGASE S: Turnover of serum proteins in rats with analbuminemia. Biochem Biophys Res Comm 87:1191-1199, 1979
50. MARSH JB, SPARKS CE: Hepatic secretion of lipoproteins in the rat and the effect of experimental nephrosis. J Clin Invest 64:1229-1237, 1979
51. MARSH JB: Lipoprotein metabolism in experimental nephrosis. J Lipid Res 25:1619-1623, 1984
52. CAVUS I, KOO PH, TEYLER TJ: Inhibition of long-term potentiation development in rat hippocampal slice by alpha 2-macroglobulin, an acute-phase protein in the brain. J Neurosci Res 43:282-288, 1996
53. ABRAHAM LJ, BRADSHAW AD, NORTHEMANN W, FEY GH: Identification of a glucocorticoid response element contributing to the constitutive expression of the rat liver alpha 1-inhibitor III gene. J Biol Chem 266:18268-18275, 1991
54. KIRSCH R, FRITH L, BLACK E, HOFFENBERG R: Regulation of albumin synthesis and catabolism by alteration of dietary protein. Nature 217:578-579, 1968
55. KAYSEN GA, GAMBERTOGLIO J, JIMINEZ I, JONES H, HUTCHISON FN: Effect of dietary protein intake on albumin homeostasis in nephrotic patients. Kidney Int 29:572-577, 1986
56. KAYSEN GA, RATHORE V: Derangements of protein metabolism in chronic renal failure. Blood Purif 14:373-381, 1996
57. SELLERS AL, KATZ J, BONORRIS G: Albumin distribution in the nephrotic rat. J Lab Clin Med 71:511-516, 1968
58. KATZ J, SELLERS AL, BONORRIS G: Effect of nephrectomy on plasma albumin catabolism in experimental nephrosis. J Lab Clin Med 63:680-686, 1964
59. GALASKE RG, BALDAMUS CA, STOLTE H: Plasma protein handling in the rat kidney: Micropuncture experiments in the acute heterologous phase of anti-GBM-nephritis. Pflügers Arch 375:269-277, 1978
60. EISENBACH GM, VAN LIEW JB, BOYLAN JW: Effect of angiotensin on the filtration of protein in the rat kidney. A micropuncture study. Kidney Int 8:80-87, 1975
61. LANDWEHR DM, CARVALHO JS, OKEN DE: Micropuncture studies of the filtration and absorption of albumin by nephrotic rats. Kidney Int 11:9-17, 1977
62. LEWY JE, PESCE A: Micropuncture study of albumin transfer in aminonucleoside nephrosis in the rat. Pediatr Res 7:553-559, 1973
63. OKEN DE, COTES SC, MENDE CW: Micropuncture study of tubular transport of albumin in rats with aminonucleoside nephrosis. Kidney Int 1:3-11, 1972
64. KATZ J, SELLERS AL, BONORRIS G: Plasma albumin metabolism during transient renin proteinuria. J Lab Clin Med 64:709-716, 1964