Protein A immunoadsorption in chronic refractory ITP reverses increased platelet activation but fails to achieve sustained clinical benefit

British Journal of Haematology

Volumn 100, Issue 2, 1998, Pages 358-364

  Cahill, M R ^a   Macey, M G ^b   Cavenagh, J D ^a   Newland, A C ^b  

^a ROYAL LONDON HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL LIMERICK   (Ireland)

Author keywords

ITP; P selectin; Platelet activation; Platelet associated immunoglobulin; Protein A immunoadsorption

Indexed keywords

CD63 ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PADGEM PROTEIN; PROTEIN A;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; FOLLOW UP; HUMAN; HUMAN CELL; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOADSORPTION; MALE; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; THROMBOCYTE LIFESPAN; TREATMENT OUTCOME;

ADULT; AGED; CHRONIC DISEASE; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOSORBENT TECHNIQUES; MALE; MIDDLE AGED; P-SELECTIN; PLATELET ACTIVATION; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; STAPHYLOCOCCAL PROTEIN A; TREATMENT FAILURE;

EID: 0031935959     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00568.x     Document Type: Article

References (33)

1. Andersen, J.C. (1994) Response of resistant idiopathic thrombocytopenic purpura to pulsed high-dose dexamethasone therapy. New England Journal of Medicine, 330, 1560-1564.
2. Balint, J.P. & Jones, F.R. (1995) Evidence for proteolytic cleavage of covalently bound protein A from a silica based extracorporeal immunoadsorbent and lack of relationship to treatment effects. Transfusion Science, 16, 85-94.
3. Berchtold, P., Dale, G.L.. Tani, P. & McMillan. R. (1989) Inhibition of autoantibody binding to platelet glycoprotein GPIIb/IIIa by antiidiotypic antibodies in intravenous gamma globulin. Blood. 74, 2414-2417.
4. Bernard. T.B., Kelsey, S.M., Macey. M.G.. Cahill, M.R., Howe, T. & Newland, A.C. (1993) Protein A column plasma immunoadsorption in refractor}' neutropenia and thrombocytopenia. Lancet. 341, 1657-1658.
5. Brighton, T.A., Evans. S., Castaldi, P.A., Chesterman. C.N. & Chong, B.H. (1996) Prospective evaluation of the clinical usefulness of an antigen-specific assay (MAIPA) in idiopathic thrombocytopenic purpura and other immune thrombocytopenias. Blood, 88, 194-201.
6. Cahill, M.R. (1995) Platelet activation: measurement and clinical significance. M.D. thesis, University of London.
7. Cahill, M.R., Macey, M.G., Dawson, J.R. & Newland, A.C. (1994) Prevention of restenosis after angioplasty. Lancet. 343, 136.
8. Cahill. M.R., Macey, M.G. & Newland, A.C. (1993) Fixation with formaldehyde induces expression of activation-dependent platelet membrane glycoproteins. British Journal ofllaematology. 84, 527-529.
9. Cahill, M.R., Macey. M.G. & Newland, A.C. (1996) Resting platelet P-selectin and GP53 fail to correlate in healthy subjects but are closely linked in myeloproliferative disorders. Blood Coagulation and Fibrinohjsis, 7, 169-171.
10. Collins, C.E.. Cahill, M.R., Newland. A.C. & Rampton, D.S. (1994) Circulating platelets are activated in inflammatory bowel disease: increased platelet aggregation in inflammatory bowel disease (IBD). Gastroenterology, 106, 840-845.
11. Debre, M., Bonnet, M.C., Fridman. W.U., Carosella, E., Philippe, N., Reinert, P., Vilmer. E., Kaplan, C., Teillaud. J.L. & Griscelli, C. (1993) Infusion of Ycy fragments for treatment of children with acute immune thrombocytopenic purpura. Lancet. 342, 945-947.
12. George, J.N. (1990) Platelet immunoglobulin G: its significance for the evaluation of thrombocytopenia and for understanding the origin of alpha granule proteins. Blood, 76, 859-870.
13. George, J.N., Saucerman, S., Levine, S.P., Knieriem, L.K. & Bainton, D.F. (1985) Immunoglobulin G is a platelet alpha granule secreted protein. Journal of Clinical Investigation, 76, 2020-2025.
14. Coding, J.W. (1978) Use of staphylococcal protein A as an immunological reagent. Journal of Immwwl Methods. 20, 241-253.
15. Goodall. A.H. (1991) Platelet activation during preparation and storage of concentrates: detection by flow cytometry. Blood Coagulation and Fibrinolijsis, 2, 377-382.
16. Goodall, A.H. & Macey. M.G. (1994) Platelet associated molecules and immunoglobulins. Flow Cytometry: Clinical Applications (ed. by M. G. Macey), pp. 148-151. Blackwell Scientific Publications. Oxford.
17. Hsu-Lin. S.-C., Berman, C.L., Furie. B.C., August, D. & Furie, B. (1984) A platelet membrane protein expressed during platelet activation and secretion: studies using a monoclonal antibody specific for thrombin activated platelets. Journal of Biological Chemistry. 259, 9121-9126.
18. Imbach, P. (1995) Immune thrombocytopenia in children: the immune character of destructive thrombocytopenia and the treatment of bleeding. Seminars in Thrombosis and Hemostasis, 21,305312.
19. Larsen, E., Cell, A. & Gilbert. G.E. (1989) PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell, 59, 305-312.
20. Manoharan, A. (1991) Treatment of refractory idiopathic thrombocytopenic purpura in adults. British Journal of Haematology. 79, 143-147.
21. McCrae, K.R., Shattil, S.J. & Cinés, D.B. (1990) Platelet activation induces increased Fc gamma receptor expression. Journal of . Immunology. 144, 3920-3927.
22. McDougal, J.S., Redecha, P.B., Inman, R.D. & Christian, C.L. (1979) Binding of immunoglobulin G aggregates and immune complexes in human sera to staphylococci containing protein A. Journal of Clinical Investigation. 63, 627-636.
23. McEver, R.P. & Martin, M.N. (1984) A monoclonal antibody to a membrane glycoprotein binds only to activated platelets. Journal of Biological Chemistry. 259, 9799-9804.
24. McMillan. R., Longmire, R.L., Yelenosky. R., Smith, R.S. & Craddock, C.G. (1972) Immunoglobulin synthesis in vitro by splenic tissue in idiopathic thrombocytopenic purpura. New England Journal of Medicine. 286, 681-684.
25. Morris, A., Macey, M. & Newland, A. (1991) Platelet immunoglobulins, glycoproteins and activation antigens in autoimune thrombocytopenic purpura (ATP). British Society for Haematology (meeting supplement), 105.
26. Newland, A.C., Treleaven, J.G., Minchinton, R.M. & Waters. A.H. (1983) High-dose intravenous IgG in adults with autoimmune thrombocytopenia. Lancet, i, 84-87.
27. Nieuwenhuis, H.K., van Oosterhout, J.J.G., Rozemuller, E., van Iwaarden, F. & Sixma, J.J. (1987) Studies with a monoclonal antibody against activated platelets: evidence that a secreted 53,000 molecular weight lysosome-Iike granule protein is exposed on the surface of activated platelets in the circulation. Blood, 73, 838-845.
28. Semple, J.W., Milev, Y., Cosgrave, D., Mody, M., Hornstein, A., Blanchette, V. & Freedman, J. (1996) Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and anti-platelet T-cell reactivity. Blood, 87, 4245-4254.
29. Snyder, H.W., Cochran, S.K.. Balint, J.P., Bertram, J.H., Mittelman, A., Githrie, T.H. & Jones, ER. (1992) Experience with protein A-immunoadsorption in treatment resistant adult immune thrombocytopenic purpura. Blood, 79, 2237-2245.
30. Sugiyama. T., Minora, 0., Ushikubi, F., Sensaki, S.. Kanaji. K. & Uchino, H. (1987) A novel platelet aggregating factor found in a platelet with defective collagen induced platelet aggregation and autoimmune thrombocytopenia. Blood. 69, 1712-1720.
31. Tschoepe, D., Driesch, E., Schwippert, B., Nieuwenhuis, H.K. & Cries, EA. (1995) Exposure of adhesion molecules on activated platelets in patients with newly diagnosed IDDM is not normalised by nearnormoglycaemia. Diabetes, 44, 890-894.
32. U'orthington, R.E., Carroll, R.C. & Boucheiux, C. (1990) Platelet activation by CD9 monoclonal antibodies is mediated by the Fc gamma II receptor. British Journal of Haematology. 74, 216-222.
33. Yanabu, M., Komura, S., Fukuroi, T., Soga, T., Kondo, K., Sone, N., Kitada, C., Nagata, II.. Kokawa, T. & Yasunaga, K. (1991) Synergistic action in platelet activation induced by antiplatelet autoantibody in IIP. British Journal of Hacmatology, 78, 87-93.