Mechanism of galanin-induced contraction of longitudinal smooth muscle of the rat jejunum

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 274, Issue 2 37-2, 1998, Pages

  Ahtaridis, Simon A ^a   Katoch, Surender S ^a   Moreland, Robert S ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Gastrointestinal smooth muscle; Guanosine triphosphate; Myofilament calcium sensitization; Myosin light chain phosphorylation; Peptide; toxin permeabilization

Indexed keywords

ALPHA TOXIN; CALCIUM; GALANIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; MYOSIN LIGHT CHAIN; PEPTIDE;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; INTESTINE CONTRACTION; INTESTINE MUSCLE; JEJUNUM; MALE; MUSCLE FORCE; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SENSITIZATION;

EID: 0031935934     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1998.274.2.g306     Document Type: Article

References (22)

1. 2+ and cyclic AMP signaling systems in smooth muscle. Cell. Signal. 3: 371-385, 1991.
2. Adam, L. P., J. R. Haeberle, and D. R. Hathaway. Phosphorylation of caldesmon in arterial smooth muscle. J. Biol. Chem. 264: 7698-7703, 1989.
3. Bishop, A., J. Polack, F. E. Bauer, N. D. Christofides, F. Carlei, and S. R. Bloom. Occurrence and distribution of a newly discovered peptide, galanin, in the mammalian enteric nervous system. Gut 27: 849-857, 1986.
4. Bolton, T. B., and P. Pacaud. Voltage-dependent calcium channels of smooth muscle. Jpn. J. Pharmacol. 58, Suppl.: 251-257, 1992.
5. Botella, A., M. Delvaux, L. Bueno, and J. Frexinos. Intracellular pathways triggered by galanin to induce contraction of pig ileum smooth muscle cells. J. Physiol. (Lond.) 458: 475-486, 1992.
6. Botella, A., M. Delvaux, J. Fioramonti, J. Frexinos, and L. Bueno. Galanin contracts and relaxes guinea pig and canine intestinal smooth muscle cells through distinct receptors. Gastroenterology 108: 3-11, 1995.
7. Courtice, G. P., J. R. S. Hales, and E. K. Potter. Selective regional vasoconstriction underlying pressor effects of galanin in anaesthetized possums compared with cats. J. Physiol. (Lond.) 481: 439-445, 1994.
8. Delvaux, M., A. Botella, J. Fioramonti, J. Frexinos, and L. Bueno. Galanin induces contraction of smooth muscle from pig ileum by a direct myogenic effect. Regul. Pept. 32: 369-374, 1991.
9. Feher, E., and G. Burnstock. Galanin-like immunoreactive nerve elements in the small intestine of the rat. An electron microscopic immunocytochemical study. Neurosci. Lett. 92: 137-142, 1988.
10. Fish, R. D., G. Sperti, W. S. Colucci, and D. E. Clapham. Phorbol ester increases the dihydropyridine-sensitive calcium conductance in a vascular smooth muscle cell line. Circ. Res. 62: 1049-1054, 1988.
11. 2+-dependent contractile effects on isolated mouse distal colon. Eur. J. Pharmacol. 164: 583-586, 1989.
12. Galizzi, J.-P., J. Qar, M. Fosset, C. Van Renterghem, and M. Lazdunski. Regulation of calcium channels in aortic muscle cells by protein kinase C activators (diacylglycerol and phorbol esters) and by peptides (vasopressin and bombesin) that stimulate phosphoinositide breakdown. J. Biol. Chem. 262: 6947-6950, 1988.
13. Gerthoffer, W. T. Calcium dependence of myosin phosphorylation and airway smooth muscle contraction and relaxation. Am. J. Physiol. 250 (Cell Physiol. 19): C597-C604, 1986.
14. Gerthoffer, W. T. Dissociation of myosin phosphorylation and active tension during muscarinic stimulation of tracheal smooth muscle. J. Pharmacol. Exp. Ther. 240: 8-15, 1987.
15. Gonda, T., E. E. Daniel, T. J. McDonald, J. E. T. Fox, B. D. Brooks, and M. Oki. Distribution and function of enteric GAL-IR nerves in dogs: comparison with VIP. Am. J. Physiol. 256 (Gastrointest. Liver Physiol. 19): G884-G896, 1989.
16. Gong, M. C., M. T. Kinter, A. V. Somlyo, and A. P. Somlyo. Arachidonic acid and diacylglycerol release associated with inhibition of myosin light chain dephosphorylation in rabbit smooth muscle. J. Physiol. (Lond.) 486: 113-122, 1995.
17. Gu, Z.-F., T. K. Pradhan, D. H. Coy, and R. T. Jensen. Galanin-induced relaxation in gastric smooth muscle cells is mediated by cyclic AMP. Peptides 15: 1425-1430, 1994.
18. Gu, Z.-F., T. K. Pradhan, D. H. Coy, and R. T. Jensen. Smooth muscle cells from guinea pig stomach possess high-affinity galanin receptors that mediate relaxation. Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29): G839-G845, 1994.
19. Gu, Z.-F., T. K. Pradhan, D. H. Coy, and R. T. Jensen. Interaction of galanin fragments with galanin receptors on isolated smooth muscle cells from guinea pig stomach: identification of a novel galanin receptor subtype. J. Pharmacol. Exp. Ther. 272: 371-378, 1995.
20. Gu, Z.-F., W. J. Rossowski, D. H. Coy, T. K. Pradhan, and R. T. Jensen. Chimeric galanin analogs that function as antagonists in the CNS are full agonists in gastrointestinal smooth muscle. J. Pharmacol. Exp. Ther. 266: 912-918, 1993.
21. 2+ influx through dihydropyridine-sensitive channels linked to activation of protein kinase C in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 188: 934-941, 1992.
22. 2+ sensitization of smooth muscle contraction through myosin light chain phosphorylation. J. Biol. Chem. 266: 1708-1715, 1991.