The effect of dexamethasone treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats

Molecular and Cellular Biochemistry

Volumn 178, Issue 1-2, 1998, Pages 325-333

  Arias, Gladys ^a,b   Asins, Guillermina ^a   Hegardt, Fausto G ^a   Serra, Dolors ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSIDAD NACIONAL MAYOR DE SAN MARCOS   (Peru)

Author keywords

Carnitine palmitoyl transferase I; Dexamethasone; Intestine; Ketogenesis; Liver; Mitochondrial HMG CoA synthase; Suckling rats

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE; DEXAMETHASONE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; INTESTINE; KETOGENESIS; LIVER; NEWBORN; NONHUMAN; RAT; REGULATOR GENE; SUCKLING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARNITINE O-PALMITOYLTRANSFERASE; DEXAMETHASONE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REGULATOR; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; INTESTINES; KETONE BODIES; LIVER; MITOCHONDRIA, LIVER; RATS; RATS, SPRAGUE-DAWLEY; WEANING;

EID: 0031935848     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006875716407     Document Type: Article

References (52)

1. McGarry D, Foster DW: Regulation of fatty acid oxidation and ketone body production. Annu Rev Biochem 49: 395-420, 1980
2. Quant PA, Tubbs PK, Brand MD: Glucagon activates mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in vivo by decreasing the extent of succinylation of the enzyme. Eur J Biochem 187: 169-174, 1990
3. Asins G, Serra D, Hegardt FG: The effect of etomoxir on the mRNA levels of enzymes involved in ketogenesis and cholesterogenesis in rat liver. Biochem Pharmacol 47: 1373-1379, 1994
4. Ferré P, Pégorier JP, Williamson DH, Girard JR: The development of ketogenesis at birth in the rat. Biochem J 176: 759-765, 1978
5. Hahn P, Taller M: Ketone formation in the intestinal mucosa of infant rats. Life Sci 41: 1525-1528, 1987
6. Girard J: Metabolic adaptations to change of nutrition at birth. Biol Neonate 58: 3-15, 1990
7. Saggerson ED, Carpenter CA: Regulation of the hepatic carnitine palmitoyltransferase activity during the foetal-neonatal transition. FEBS Lett 150: 177-180, 1982
8. Quant PA, Robin D, Robin P, Ferré P, Brand MD, Girard J: Control of hepatic mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase during the foetal-neonatal and suckling-weaning transitions in the rat. Eur J Biochem 195: 449-454, 1991
9. Hahn P, Chanez C, Hamilton J: Carnitine and carnitine transferases in the intestinal mucosa of suckling rats. Biol Neonate 48: 77-84, 1985
10. Békési A, Williamson DH: An explanation for ketogenesis by the intestine of the suckling rat: The presence of an active hydroxymethylglutaryl coenzyme A pathway. Biol Neonate 58: 160-165, 1990
11. Foster PC, Bailey E: Changes in the activities of the enzymes of hepatic fatty acid oxidation during development of the rat. Biochem J 154: 49-56, 1976
12. Serra D, Asins G, Hegardt FG: Ketogenic mitochondrial 3-hydroxy- 3-methylglutaryl-CoA synthase gene expression in intestine and liver of suckling rats. Arch Biochem Biophys 301: 445-448, 1993
13. Asins G, Serra D, Arias G, Hegardt FG: Developmental changes in carnitine palmitoyltransferases I and II gene expression in intestine and liver of suckling rats. Biochem J 306: 379-384, 1995
14. Page MA, Krebs HA, Williamson DH: Activities of enzymes of ketone-body utilization in brain and other tissues of suckling rats. Biochem J 121: 49-53, 1971
15. Yeh Y-Y, Zee P: Insulin: a possible regulator of ketosis in newborn and suckling rats. Pediat Res 10: 192-197, 1976
16. Novak M, Melichar V, Hahn P, Kolodovsky O: Release of free fatty acids from adipose tissue obtained from newborn infants. J Lipid Res 6: 91-95, 1965
17. Ballard FJ, Hanson RW: Changes in lipid synthesis in rat liver during development. Biochem J 102: 952-958, 1967
18. Ferré P, Decaux JF, Issad T, Girard J: Changes in energy metabolism during the suckling and weaning period in the newborn. Reprod Nutr Dev 26: 619-631, 1986
19. Girard J, Cuendet GS, Marliss EB, Kervrarn A, Rieutort M, Assan R: Fuels, hormones and liver metabolism at term and during the early postnatal period in the rat. J Clin Invest 52: 3190-3200, 1973
20. McGarry JD, Wright PH, Foster DW: Hormonal control of ketogenesis. Rapid activation of hepatic ketogenesis capacity in fed rats by antiinsulin serum and glucagon. J Clin Invest 55: 1202-1209, 1975
21. Unger RH: Glucagon physiology and pathophysiology in the light of new advances. Diabetologia 28: 574-578, 1985
22. Bassett JM, Alexander G: Insulin, growth hormone and corticosteroids in neonatal lambs. Normal concentrations and the effect of cold. Biol Neonate 17: 112-125, 1971
23. Haymond MW, Karl I, Pagliara AS: Increased gluconeogenesis substrates in the small-for-gestational age infant. N Engl J Med 291: 322-328, 1974
24. Malinowska KW, Hardy RN, Nathanieiz PW: Plasma adrenocorticosteroid concentrations immediately after birth in infant rat, rabbit and guinea pig. Experientia Basel 28: 1366-1367, 1972
25. Henning SJ: Plasma concentrations of total and free corticosterone during development in the rat. Am J Physiol 235: (Endocrinol Metab Gastrointest Physiol 4): E451-E456, 1978
26. Agius L, Chowdhury MH, Alberti GMM: Regulation of ketogenesis, gluconeogenesis and the mitochondrial redox state by dexamethasone in hepatocyte monolayer cultures. Biochem J 239: 593-601, 1986
27. Casals N, Roca N, Guerrero M, Gil-Gomez G, Ayté J, Ciudad CJ, Hegardt FG: Regulation of the expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene. Biochem J 283: 261-264, 1992
28. Hahn P, Taller M, Srubiski L, Kirby L: Regulation of ketone formation and phosphoenolpyruvate carboxykinase activity in the small intestinal mucosa of infant rats. Biol Neonate 60: 1-6, 1991
29. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual. 2nd Ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y. 1989
30. Esser V, Britton CH, Weis BC, Foster DW, McGarry JD: Cloning, sequencing and expression of a cDNA encoding rat liver carnitine palmitoyltransferase. J Biol Chem 268: 5817-5822, 1993
31. Asins G, Rosa JL, Serra D, Gil-Gómez G, Ayté J, Bartrons R, Tauler A, Hegardt FG: Gene expression of enzymes regulating ketogenesis and fatty acid metabolism in regenerating rat liver. Biochem J 299: 65-69, 1994
32. Ayté J, Gil-Gómez G, Haro D, Marrero P, Hegardt FG: Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA syntheses are encoded by two different genes. Proc Natl Acad Sci USA 87: 3874-3878, 1990
33. Hanson PJ, Carrington JM: Activity of 3-oxo acid CoA-transferase, D-3-hydroxybutyrate dehydrogenase, hexokinase and carnitine palmitoyl-transferase in the stomach and small and large intestine of the rat. Biochem J 200: 349-355, 1981
34. Saggerson ED, Carpenter CA: Carnitine palmitoyltransferase in liver and five extrahepatic tissues in the rat. Inhibition by DL-2-bromopalmitoyl-CoA and effect of hypothyroidism. Biochem J 236: 137-141, 1986
35. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976
36. Thumelin S, Esser V, Charvy D, Kolodziej M, Zammit VA, McGarry D, Girard J, Pègorier JP: Expression of liver carnitine palmitoyltransferase I and II genes during development in the rat. Biochem J 300: 583-587, 1994
37. Clinkenbeard KD, Reed WD, Mooney RA, Lane MD: Intracellular localization of the 3-hydroxy-3-methylglutaryl coenzyme A cycle enzymes in liver. Separate cytoplasmic and mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A generating systems for cholesterogenesis and ketogenesis. J Biol Chem 250: 3108-3116, 1975
38. Williamson DH, Mellanby J, Krebs HA: Enzymic determination of D(-)-b-Hydroxybutyric acid and acetoacetic acid in blood. Biochem J 82: 90-96, 1962
39. Blazquez E, Sugase M, Blazquez M, Foa PP: Changes in serum growth hormone levels from fetal to adult age in the rat. J Lab Clin Med 83: 957-967, 1974
40. Girard J, Sperling M: Glucagon in the fetus and the newborn. In: PJ Lefebvre (ed). Glucagon. Berlin: Springer Verlag vol 2,1983, pp 251-274
41. Ktorza A, Bihoreau MT, Nurjhan N, Picon L, Girard J: Insulin and glucagon during the perinatal period: Secretion and metabolic effects on the liver. Biol Neonate 48: 204-220, 1985
42. Drahota Z, Hahn A, Kleinzeller A, Kostolanska A: Acetoacetate formation by liver slices from adult and infant rat. Biochem J 93: 61-65, 1964
43. Chalk PA, Higham FC, Caswell AM, Baile E: Hepatic mitochondrial fatty acid oxidation during the perinatal period in the rat. Int J Biochem 15: 531-538, 1983
44. Arias G, Asins G, Hegardt FG, Serra D: The effect of fasting and insulin treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats. Arch Biochem Biophys 340: 287-298, 1997
45. Chalk PA, Higham FC, Caswell AM, Baile E: Hepatic mitochondrial fatty acid oxidation during the perinatal period in the rat. Int J Biochem 15: 531-538, 1983
46. Arias G, Asins G, Hegardt FG, Serra D: The effect of fasting and insulin treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats. Arch Biochem Biophys 340: 287-298, 1997
47. Kedinger M, Simon PM, Raul F, Grenier JF, Haffen K: The effect of dexamethasone on the development of rat intestinal brush border enzymes in organ culture. Dev Biol 74: 9-21, 1980
48. Levenson CW, Shay NF, Lee-Ambrose LM, Cousins RJ: Regulation of cysteine-rich intestinal protein by dexamethasone in the neonatal rat. Proc Natl Acad Sci USA 90: 712-715, 1993
49. Leeper LL, Henning SJ: Hormonal control of postnatal development of Heal neuraminidase and acid beta galactosidase. Biol Neonate 44: 28-35, 1983
50. Martin GR, Henning SJ: Enzymic development of the small intestine: Are glucocorticoids necessary? Am J Physiol 246 (Gastointest Liver Physiol 9): G695-G699, 1984
51. Henning SJ, Leeper LL: Coordinate loss of glucocorticoid responsiveness by intestinal enzymes during postnatal development. Am J Physiol 242 (Gastrointest Liver Physiol 5): G89-G94, 1982
52. Thumelin S, Forestier M, Girard J, Pégorier JP: Developmental changes in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in rat liver, intestine and kidney. Biochem J 292: 493-496, 1993