Sleep-endocrine effects of mifepristone and megestrol acetate in healthy men

American Journal of Physiology - Endocrinology and Metabolism

Volumn 274, Issue 1 37-1, 1998, Pages

  Wiedemann, Klaus ^a   Lauer, Christoph J ^a   Hirschmann, Margarete ^a   Knaudt, Kristina ^a   Holsboer, Florian ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Adrenocorticotropic hormone; Cortisol; Glucocorticoids; Growth hormone; Progesterone; Sleep electroencephalogram

Indexed keywords

MEGESTROL ACETATE; MIFEPRISTONE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOTROPIN RELEASE; ELECTROENCEPHALOGRAM; GROWTH HORMONE RELEASE; HUMAN; HYDROCORTISONE RELEASE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROGESTERONE RELEASE; SLEEP;

EID: 0031935412     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.274.1.e139     Document Type: Article

References (41)

1. Baulieu, E. E. Neurosteroids: a new function in the brain. Biol. Cell 71: 3-10, 1991.
2. Beck, C. A., P. A. Estes, B. J. Bona, C. A. Muro-Cacho, S. K. Nordeen, and D. P. Edwards. The steroid antagonist RU 486 exerts different effects on the glucocorticoid and progesterone receptors. Endocrinology 133: 728-740, 1993.
3. Bellantoni, M. F., J. Vittone, A. T. Campfield, K. M. Bass, S. M. Harman, and M. R. Blackman. Effects of oral versus transdermal estrogen on the growth hormone/insulin-like growth factor I axis in younger and older postmenopausal women: a clinical research center study. J. Clin. Endocrinol. Metab. 81: 2848-2853, 1996.
4. Bertagna, X., C. Bertagna, M.-H. Laudat, J.-M. Husson, F. Girard, and J.-P. Luton. Pituitary-adrenal response to the antiglucocorticoid action of RU 486 in Cushing's syndrome. J. Clin. Endocrinol. Metab. 63: 639-643, 1986.
5. Born, J., E. R. de Kloet, H. Wenz, W. Kern, and H. L. Fehm. Gluco- and antimineralocorticoid effects on human sleep: a role of central corticosteroid receptors. Am. J. Physiol. 260 (Endocrinol. Metab. 23): E183-E188, 1991.
6. Botella, J., J. Porthe-Nibelle, J. Paris, and B. Lahlou. Interaction of new 19 nor progesterone derivatives with progestagen, mineralocorticoid and glucocorticoid cytosolic receptors. J. Pharmacol. 17: 699-706, 1986.
7. Branchey, M., and O. Petre-Quadens. A comparative study of sleep parameters during pregnancy. Acta Neurol. Belg. 68: 453-459, 1968.
8. A receptors mediate 3α-hydroxy-5α-pregnan-20-one-induced gonadotropin secretion. Endocrinology 126: 1854-1859, 1990.
9. Ceda, G. P., R. G. Davis, and A. R. Hoffman. Glucocorticoid modulation of growth hormone secretion in vitro: evidence for a biphasic effect on GH-releasing hormone mediated release. Acta Endocrinol. 114: 465-469, 1987.
10. Cluydts, R., and P. Visser. Mood and sleep. 1. Effects of the menstrual cycle. Waking Sleeping 4: 193-197, 1980.
11. Cooke, B. A., T. J. McDonald, and D. K. Vallance. Metabolism of 17α-acetoxy-6-methylpregna-4,6-diene-3,20-dione in the rat. Biochem. J. 97: 25-26, 1965.
12. David, A., K. Edwards, K. P. Fellowes, and J. M. Plummer. Anti-ovulatory and other biological properties of megestrol acetate 17α-acetoxy-6-methylpregna-4,6-diene-3,20-dione (B.D.H. 1298). J. Reprod. Fertil. 5: 331-346, 1963.
13. Driver, H. S., D. J. Dijk, E. Werth, K. Biedermann, and A. A. Borbely. Sleep and the sleep electroencephalogram across the menstrual cycle in young healthy women. J. Clin. Endocrinol. Metab. 81: 728-735, 1996.
14. Driver, H. S., and C. M. Shapiro. A longitudinal study of sleep stages in young women during pregnancy and postpartum. Sleep 15: 449-453, 1992.
15. Friess, E., L. Trachsel, J. Guldner, T. Schier, A. Steiger, and F. Holsboer. DHEA administration increases rapid-eye-movement sleep and EEG power in the sigma frequency range. Am. J. Physiol 268 (Endocrinol. Metab. 31): E107-E113, 1995.
16. Gillin, J. C., L. S. Jacobs, D. H. Fram, and F. Snyder. Acute effect of a glucocorticoid on normal human sleep. Nature 237: 398-399, 1972.
17. Gravanis, A., G. Schaison, M. Georges, J. de Brux, P. G. Satyaswaroop, E. G. Baulieu, and P. Robel. Endometrial and pituitary responses to the steroidal antiprogestin RU 486 in postmenopausal women. J. Clin. Endocrinol. Metab. 60: 156-163, 1985.
18. Hertz, G., A. Fast, S. H. Feinsilver, C. L. Albertario, H. Schulman, and A. M. Fein. Sleep in normal late pregnancy. Sleep 15: 246-251, 1992
19. Ito, M., M. Kohsaka, N. Fukuda, K. Honma, S. Honma, Y. Katsuno, H. Honma, I. Kawai, N. Morita, and T. Miyamoto. Effects of menstrual cycle on plasma melatonin level and sleep characteristics. Jpn. J. Psychiatry Neurol. 47: 478-479, 1993.
20. Jahn, G. A., L.-M. Houdebine, and J. Djiane. Antiprogesterone and antiglucocorticoid actions of RU 486 on rabbit mammary gland explant cultures. Evidence for a persistent inhibitory action of residual progesterone upon the mammary tissue. J. Steroid Biochem. 28: 371-377, 1987.
21. Kastner, P., M. T. Bocquel, B. Turcotte, J.-M. Garnier, K. B. Horwitz, P. Chambon, and H. Gronemeyer. Transient expression of human, and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms. J. Biol. Chem. 265: 12163-12167, 1990.
22. Kato, J., S. Hirata, A. Nozawa, and N. Yamada-Mouri. Gene expression of progesterone receptor isoforms in the rat brain. Horm. Behav. 28: 454-463, 1994.
23. Komisaruk, B. R., P. G. McDonald, D. I. Whitmoyer, and C. H. Sawyer. Effects of progesterone and sensory stimulation on EEG and neuronal activity in the rat. Exp. Neurol. 19: 494-507, 1967.
24. Lamberts, S. W. J., P. Uitterlinden, E. G. Bons, and T. Verleun. Comparison of the actions of RU 38486 and megestrol acetate in the model of a transplantable adrenocorticotropin- and prolactin-secreting rat pituitary tumor. Cancer Res. 45: 1015-1019, 1985.
25. Lauer, C. J., D. Riemann, M. Wiegand, and M. Berger. From early to late adulthood: changes in EEG sleep of depressed patients and healthy volunteers. Biol. Psychiatry 29: 979-993, 1991.
26. Lee, K. A., J. F. Shaver, E. C. Giblin, and N. F. Woods. Sleep patterns related to menstrual cycle phase and premenstrual affective symptoms. Sleep 13: 403-409, 1990.
27. Meyer, M. A., A. Pornon, J. Ji, M.-T. Bocquel, P. Chambon, and H. Gronemeyer. Agonistic and antagonistic activities of RU 486 on the functions of the human progesterone receptor. EMBO J. 9: 3923-3932, 1990.
28. Morissette, M., L.-M. Garcia-Segura, A. Bélanger, and T. di Paolo. Changes of rat striatal neuronal membrane morphology and steroid content during the estrous cycle. Neuroscience 49: 893-902, 1992.
29. Pares, J. D. Sleep and the menstrual cycle. In: Sleep and Its Disorders. London: Saunders, 1985, p. 320-334.
30. Parry, B. L., W. B. Mendelson, W. C. Duncan, D. A. Sack, and T. A. Wehr. Longitudinal sleep EEG, temperature, and activity measurements across the menstrual cycle in patients with premenstrual depression and in age-matched controls. Psychiatry Res. 30: 285-303, 1989.
31. Paul, S. M., and R. H. Purdy. Neuroactive steroids. FASEB J. 6: 2311-2322, 1992.
32. Philibert, D., M. Moguilewsky, I. Mary, D. Lecaque, C. Tournemine, J. Secchi, and R. Deraedt. Pharmacological profile of RU 486 in animals. In: The Antiprogestin Steroid RU 486 and Human Fertility Control, edited by E. Beaulieu and S. J. Segal. New York: Plenum, p. 49-68, 1985.
33. Schiff, I., Q. Regestein, D. Tulchinsky, and K. J. Ryan. Effects of estrogens on sleep and psychological state of hypogonadal women. JAMA 242: 2405-2414, 1979.
34. Schonbrunn, A. Glucocorticoids down-regulate somatostatin receptors on pituitary cells in culture. Endocrinology 110: 1147-1154, 1982.
35. Spindler, R. S., S. H. Mellon, and J. D. Baxter. Growth hormone gene transcription is regulated by thyroid and glucocorticoid hormones in cultured rat pituitary tumor cells. J. Biol. Chem. 257: 11627-11632, 1982.
36. Stahl, M. L., W. C. Orr, and J. L. Males. Progesterone levels and sleep-related breathing during menstrual cycles of normal women. Sleep 8: 227-230, 1985.
37. Steiger, A., R. Rupprecht, D. Spengler, J. Guldner, U. Hemmeter, B. Rothe, K. Damm, and F. Holsboer. Functional properties of deoxycorticosterone and spironolactone: molecular characterization and effects on sleep-endocrine activity. J. Psychiatr. Res. 27: 275-284, 1993.
38. Stewart, E. A., D. J. Austin, P. Jain, M. D. Penglase, and R. A. Nowak. RU 486 suppresses prolactin production in explant cultures of leiomyoma and myometrium. Fertil. Steril. 65: 1119-1124, 1996.
39. Trapp, T., and F. Holsboer. Heterodimerization between mineralocorticoid and glucocorticoid receptors increases the functional diversity of corticosteroid action. Trends Pharmacol. Sci. 17: 145-149, 1996.
40. Wiedemann, K., C. Lauer, T. Pollmächer, and F. Holsboer. Sleep endocrine effects of antigluco- and antimineralocorticoids in healthy males. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E109-E114, 1994.
41. Zanisi, M., and L. Martini. Interaction of oestrogen and of physiological progesterone metabolites in the control of gonadotropin secretion. J. Steroid Biochem. 11: 855-862, 1979.