Special stains, the old and the new: The impact of immunocytochemistry in effusion cytology

Diagnostic Cytopathology

Volumn 18, Issue 2, 1998, Pages 141-149

  Bedrossian, Carlos W M ^a,b  

^a HUTZEL HOSPITAL   (United States)

^b NORTHWESTERN MEMORIAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CYTODIAGNOSIS; CYTOLOGY; DIAGNOSTIC ACCURACY; EFFUSION; IMMUNOCYTOCHEMISTRY; PRIORITY JOURNAL; REVIEW; STAINING;

ALGORITHMS; ASCITIC FLUID; CYTODIAGNOSIS; EXUDATES AND TRANSUDATES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PERICARDIAL EFFUSION; PLEURAL EFFUSION, MALIGNANT; STAINING AND LABELING; TUMOR MARKERS, BIOLOGICAL;

EID: 0031935358     PISSN: 87551039     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0339(199802)18:2<141::AID-DC11>3.0.CO;2-L     Document Type: Review

References (100)

1. Reinhardt B. Uber die sogenannte Spalbarkeit der Zellenkerne. Virchows Arch [A] 1847;1:528.
2. Bennett JH. On cancerous and cancroid growths. Edinburgh: Sutherland and Know, 1849.
3. Erlich P. Beitrage zur Atiologie and Histologie pleuritischer Exsudate. Charite Ann 1882;7:199-203.
4. Raspail FV. Essai de chimie microscopique appliqée à la physiologie. Paris: Meilhac, 1830.
5. Zemansky AP. Examination of fluids for tumor cells: an analysis of 113 cases checked against subsequent examination of tissue. Am J Med Sci 1928;175:489.
6. Naylor B. Pleural, peritoneal and pericardial fluids. In: Bibbo M, ed. Comprehensive cytopathology. Philadelphia: 1991. WB Saunders.
7. Frost JK. Concepts basic to general cytopathology. 1st ed. Baltimore: Johns Hopkins Press, 1959.
8. McDougall D, Wang SE, Zidar BL. Mucin-positive epithelial mesothelioma. Arch Pathol Lab Med 1992;116:874-880.
9. Sternberger LA, Hardy PH, Cuculis JJ, et al. The unlabelled antibody enzyme method of histochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-anti horse- radish peroxidase) and its use in the identification of spirochaetes. J Histochem Cytochem 1970;18:315-333.
10. Köhler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975;256:495-497.
11. Coleman DV, Ormerod MB. Tumor markers in cytology. In: Koss LG, Coleman DV, eds. Advances in clinical cytology. Vol 2. New York: Masson, 1981.
12. Nance KV, Silverman JF. The utility of ancillary techniques in effusion cytology. Diagn Cytopathol 1991;8:185-189.
13. Visscher DW, Sarkar FH, Wolman SR, Bedrossian CWM. Theory and methodology of evaluating genetic alterations. Diagn Cytopathol 1994;10:289-297.
14. Bedrossian CWM. Immunocytochemistry. In: Astarita R, ed. Practical cytopathology. London: Churchill Livingstone, 403-457.
15. Bedrossian CWM, Masood S. Immunocytochemistry applied to cytological specimens. In: Leon AS-Y, ed. Applied immunohistochemistry for the surgical pathologist. London: Edward Arnold, 1993:342-376.
16. O'Brien JM, Kirkham SE, Burke B, et al. CEA, ZGM and EMA. Localization in cells of pleural and peritoneal effusion: preliminary study. Invest Cell Pathol 1980;3:251-258.
17. Khan HJ, Hanna W, Yeger H, et al. Immunohistochemical localization of prekeratin filaments in benign and malignant cells in effusions: comparison with intermediate filament distribution by electron microscopy. Am J Pathol 1982;109:206.
18. To A, Dearnsley D, Omerod M, et al. Epithelial membrane antigen its use in the cytodiagnosis of malignancy in serous effusion. Am J Clin Pathol 1982;78:214-219.
19. Epenetos A, Canti G, Taylor-Papadimitriou J, et al. Use of two epithelium-specific monoclonal antibodies for diagnosis of malignancy in serous effusions. Lancet 1982;2:1004-1006.
20. Woods JC, Spriggs AI, Harris H, McGee JO'D. A new marker for human cancer cells (3). Immunocytochemical detection of malignant cells in serous fluids with the Ca-1 antibody. Lancet 1982;2:512-515.
21. Walts AE, Jonathan WS, Banks-Schlegel S. Keratin and carcinoembryonic antigen in exfoliated mesothelial and malignant cells: an immunoperoxidase study. Am J Clin Pathol 1983;80:671-676.
22. Orell SR, Dowling KD. Oncofetal antigens as tumor markers in the cytologic diagnosis of effusions. Acta Cytol 1983;27:625-629.
23. Sehested M, Ralfkjaer E, Rasmussen J. Immunoperoxidate demonstration of carcinoembryonic antigen in pleural and peritoneal effusions. Acta Cytol 1983;27:124-127.
24. Ghosh A, Spriggs A, Taylor-Papadimitriou J, et al. Immunocytochemical staining of cells in pleural and peritoneal effusions with a panel of monoclonal antibodies. J Clin Pathol 1983;36:1154-1164.
25. Marshall RJ, Herbert A, Braye SG, et al. Use of antibodies to carcinoembryonic antigen and human milk fat globule to distinguish carcinoma, mesothelioma, and reactive mesothelium. J Clin Pathol 1984;37:1215.
26. Szpak C, Johnston W, Lottich A, et al. Patterns of reactivity of four novel monoclonal antibodies (B72.3. DF3, B1.1 and B6.2) with cells in human malignant and benign effusions. Acta Cytol 1984;28:356- 357.
27. Walts AE, Said JW, Shintaku IP, Sassoon AF, Banks-Schlegel. Keratins of different molecular weight in exfoliated mesothelial adenocarcinomu cells - An aid to cell identification. Am J Clin Pathol 1984;81:422-426.
28. Menard S, Rilke F, Della-Torre G, et al. Sensitivity enhancement of the cytologic detection of cancer cells in effusions by monoclonal antibodies. Am J Clin Pathol 1985;83:571-576.
29. Johnston WW, Szpak CA, Lottich SC, Thor A, Schlom J. Use of a monoclonal antibody (B72.3) as an immunocytochemical adjunct to diagnosis of adenocarcinoma in human effusions. Cancer Res 1985;45:1984-1990.
30. Singer S, Boddington MM, Hudson EA. Immunocytochemical reaction of Ca1 and HMFG-2 monoclonal antibodies with cells from serous effusions. J Clin Pathol 1985;38:180-184.
31. Kyrkou KA, Iatridis SG, Athanassiadou PP, Athanassiadis PP, Mandragos CE. The cytologic application of carcinoembryonic antigen for the discrimination of malignant from benign serous effusions. Cancer Detect Prev 1985;8:247-254.
32. Osamura RY, Watunabe K, Akatsuka Y, Peroxidase-labeled antibody staining for carcinoembryonic antigen of cytoloaic specimens for light and electron microscopy. Acta Cytol 1985;29:254-256.
33. Hilborne L, Cheng L, Nieberg R, Lewin K. Evaluation of an antibody to human milk fat globule antigen in the detection of metastatic carcinoma in pleural, pericardial and peritoneal fluids. Acta Cytol 1986;30:245-249.
34. Pinto M. An immunoperoxidase study of S-100 protein in neoplastic cells in serous effusions. Acta Cytol 1986;30:240-244.
35. Banner B, Warren W, Gould V. Cytomorphology and marker expression of malignant neuroendocrine cells in pleural effusions. Act Cytol 1986;30:99-104.
36. Martin SE, Moshiri S, Thor A, Vilasi V, Chu EW, Schlom J. Identification of adenocarcinoma in cytospin preparations of effusions using monoclonal antibody B72.3. Am J Clin Pathol 1986;86:10-18.
37. Walts AE, Said JW, Shintaku IP. Epithelial membrane antigen in the cytodiagnosis of effusions and aspirates: immunocytochemical and ultrastructural localization in benign and malignant cells. Diagn Cytopathol 1987;3:41-49.
38. Silverman J. The use of immunoperoxidase panels for the cytologic diagnosis of malignancy in serous effusions. Diagn Cytopathol 1987;3:134-140.
39. Mason MR, Bedrossian CWM, Fahey CA. Value of immunocytochemistry in the study of malignant effusions. Diagn Cytopathol 1987;3:215- 221.
40. Cibas ES, Corson JM, Pinkus GS. The distinction of adenocarcinoma from malignant mesothelioma in cell blocks of effusions. Hum Pathol 1987;18:67-74.
41. Permanetter W, Wiesinger H. Immunohistochemical study of lysozyme, alpha-1-anti-chymotrypsin, tissue polypeptide antigen, keratin, and carcinoembryonic antigen in effusion sediments. Acta Cytol 1987;31:104-112.
42. Duggan MA, Masters CB, Alexander F. Immunohistochemical differentiation of malignant mesothelioma, mesothelial hyperplasia and metastatic adenocarcinoma in serous effusions, utilizing staining for carcinoembryonic antigen, keratin and vimentin. Acta Cytol 1987;31:807-814.
43. Guzman J, Costabel U, Bross KJ, Wiehle U, Grunert F, Schaefer HE. The value of the immunoperoxidase slide assay in the diagnosis of malignant pleural effusions in breast cancer. Acta Cytol 1988;32:188- 192.
44. Croonen AM, van der Valk P, Herman CJ, Lindeman J. Cytology, immunopathology and flow cytometry in the diagnosis of pleural and peritoneal effusions. Lab Invest 1988;58:725-732.
45. Van der Kwast TH, Versnel MA, Delahaye M, de Jong A, Zondervan PE, Hoogsteden H. Expression of epithelial membrane antigen on malignant mesothelial cells. An immunocytochemical and immunoelectron microscope study. Acta Cytol 1988;32:169-174.
46. Guzman J, Hilgarth M, Bross KJ, et al. Malignant ascites of serous papillary ovarian adenocarcinoma. An immunocytochemical study of the tumor cells. Acta Cytol 1988;32:519-522.
47. Lauritzen AF. Diagnostic value of monoclonal antibody B72.3 in detecting adenocarcinoma cells in serous effusions. Acta Pathol Microbiol Immunol Scand 1989;97:761-766.
48. Rosen-Levin E, Patic JR, Watson CW, Jagirda J. Distinguishing benign from malignant pleural effusions by lectin immunocytochemistry Acta Cytol 1989;33:499-504.
49. Li C-Y, Ziesmer SC, Wong Y-C, Yam LT. Diagnostic accuracy of the immunocytochemical study of body fluids. Acta Cytol 1989;33:667- 673.
50. Linari A, Bussolati G. Evaluation of impact of immunocytochemical techniques in cytological diagnosis of neoplastic effusions. J Clin Pathol 1989;42:1184-1189.
51. Loy TS, Diaz-Arias AA, Bickel JT. Value of BCA-225 in the cytologic diagnosis of malignant effusions: an immunocytochemical study of 197 cases. Mod Pathol 1990;3:294-297.
52. Latza U, Niedobitek G, Schwarting R, Nekarda H, Stein H. Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelia. J Clin Pathol 1990;43:213-219.
53. Tickman RJ, Cohen C, Varma VA, Fekete PS, DeRase PB. Distinction between carcinoma cells and mesothelioma cells in serous effusions. Usefulness of immunohistochemistry. Acta Cytol 1990;34:491-496.
54. Al-Naffussi A, Carder PJ. Monoclonal antibodies in the cytodiagnosis of serous effusions. Cytopathology 1990;1:119-128.
55. Esteban JM, Yokota S, Husain S. et al. Immunocytochemical profile of benign and carcinomatous effusions - A practical approach to difficult diagnosis. Am J Clin Pathol 1990;94:698-705.
56. Sheahan K, O'Brien MJ, Burke B, et al. Differential reactivities of carcinoembryonic antigen (CEA) and CEA-related monoclonal and polyclonal antibodies in common epithelial malignancies. Am J Clin Pathol 1990;94:157-164.
57. Leong AS-Y, Parkinson R, Milios J. "Thick" cell membranes revealed by immunocytochemical staining: a clue to the diagnosis of mesothelioma. Diagn Cytopathol 1990;6:9-13.
58. Mottolese M, Salzano M, Vincenzoni C, et al. The use of a panel of monoclonal antibodies can lower false-negative diagnoses of peritoneal washings in ovarian tumors. Cancer 1991;68:1803.
59. Gioanni J, Caldani C, Zanghellini E, Mazeau C, Duplay H, Ferrua B, Schneider M. A new epithelial membrane antigen (Calam 27) as a marker of carcinoma in serous effusions. Acta Cytol 1991;35:315- 319.
60. Nance KV, Silverman JF. Immunocytochemical panel for the identification of malignant cells in serous effusions. Am J Clin Pathol 1991;95:867-874.
61. Mottolese M, Cianciulli A, Venturo I, et al. Selected monoclonal antibodies can increase the accuracy of cytodiagnosis of neoplastic effusions of cryptic origin expanded in a short term culture. Diagn Cytopathol 1992;8:153-160.
62. De Angelis M, Buley ID, Heryet A, Gray W. Immunocytochemical staining of serous effusions with monoclonal antibody Ber-EP4. Cytopathology 1992;3:111-117.
63. Stoop JA, Hendriks JGM, Berends D. Identification of malignant cells in serous effusions using a panel of monoclonal antibodies Ber-EP4, MCA-b-12 and EMA. Cytopathology 1992;3:297-302.
64. Daste G, Serre G, Maunduyt MA, Vincent C, Cavariviere P, Soleil- Havoup JP. Immunophenotyping of mesothelial cells and carcinoma cells with monoclonal antibodies to cytokeratins, vimentin, CEA and EMA improves the cytodiagnosis of effusions. Cytopathology 1992;2:19-28.
65. Mezger J, Stotzer O, Schilli G, Bauer S, Wilmanns W. Identification of carcinoma cells in ascitic and pleural fluid. Comparison of four panepithelial antigens with carcinoembryonic antigen. Acta Cytol 1992;36:75-81.
66. Kocjan G, Sweeney E, Miller KD, Bobrow L. AUA1 : new immunocytochemical marker for detecting epithelial cells in body cavity fluids. J Clin Pathol 1992;45:358-359.
67. Diaz-Arias A, Loy TS, Bickel JT, Chapman RK. Utility of Ber-EP4 in the diagnosis of adenocarcinoma in effusions: an immunocytochemical study of 232 cases. Diagn Cytopathol 1993;9:516-521.
68. Cajulis RS, Szumel R, Frias-Hidvegi D, Combs SG, Radosevich JA. Monoclonal antibody 44-3A6 as an adjunct in cytodiagnosis of adenocarcinomas in body fluids. Diagn Cytopathol 1993;9:179-183.
69. Flynn MK, Johnston W, Bigner S. Carcinoma of ovarian and other origins in effusions. Immunocytochemical study with a panel of monoclonal antibodies. Acta Cytol 1993;37:439-447.
70. Frisman DM, Buckner SH, Nocito JD, Macsella R. Use of monoclonal antibody BerEP4 in diagnosis of effusion.
71. MaGuire B, Whitaker D, Carrello S, Spagnolo D. Monoclonal antibody Ber-EP4: its use in the differential diagnosis of malignant mesothelioma and carcinoma in cell blocks of malignant effusions and FNA specimens. Diagn Cytopathol 1994;10:130-134.
72. Athanassiadou P, Athanassiadis P, Lazaris D, Krykou K, Petrakakou E, Aravantinos D. Immunocytochemical differentiation of reactive mesothelial cells and adenocarcinoma cells in serous effusions with the use of carcinoembryonic antigen and fibronectin. Acta Cytol 1994;38:718-722.
73. Ferrandez-Izquierdo A, Navarro-Fos S, Gonzalez-Devesa M, Gil- Benso R, Llombart-Bosch A. Immunocytochemical typification of mesothelial cells in effusions: in vivo and in vitro models. Diagn Cytopathol 1994;10:256-262.
74. Lidang JM, Johunsen P. Immunocytochemical staining of serous effusions: an additional method in the routine cytology practice? Cytopathology 1994;5:93-103.
75. Ruitenbeek T, Gown AS, Poppema S. Immunocytology of body cavity fluids. MOC-31, a monoclonal antibody discriminating between mesothelial and epithelial cells. Arch Pathol Lab Med 1994;118:265- 269.
76. Illingworth AL, Young JA, Johnson GD. Immunofluorescent staining of metastatic carcinoma cells in serous fluid with carcinoembryonic antibody, epithelial membrane antibody. AUA-1 and Ber-EP4. Cytopathology 1994;5:270-281.
77. Ascoli V, Taccogna S, Carnovale S, Nardi F. Utility of cytokeratin 20 in identifying the origin of metastatic carcinomas in effusions. Diagn Cytopathol 1995;12:303-308.
78. Singh HK, Silverman JF, Berns L, Haddad MG, Park HK. The significance of epithelial membrane antigen in the workup of problematic serous effusions. Diagn Cytopathol 1995;13:xxx-xxx.
79. Shield PW, Callan JJ, Devine PL. Markers for metastatic adenocarcinoma in serous effusion specimens. Diagn Cytopathol 1995;11:1-9.
80. Modzelewski JR Jr, Silverman JF, Berns L, Sobiesky MW, Finley GL. Serous effusion cytology in gynecologic malignant mixed Müllerian tumors. Diagn Cytopathol 1995;12:309-312.
81. Delahaye M, Hoogsteden HC, Van der Kwast TH. Immunocytochemistry of malignant mesothelioma: OV632 as a marker of malignant mesothelioma. J Pathol 1991;165:137-143.
82. Kuhlmann L, Berghauser KH, Schaffer R. Distinction of mesothelioma from carcinoma in pleural effusions. An immunocytochemical study on routinely processed cytoblock preparations. Pathol Res Pract 1991;187:467-471.
83. Donna A, Betta PG, Bellingeri D, Tallarida F, Pavesi M, Pastormerlo M. Cytologic diagnosis of malignant mesothelioma in serous effusions using an antimesothelial-cell antibody. Diagn Cytopathol 1992;8:361-365.
84. Trevisan MS, Souza MI, Magna LA. Nucleolar organiser regions of mesothelial and carcinomatous cells in effusions. Diagn Cytopathol 1993;9:492-497.
85. Gattoretti G, Becker MH, Key G, et al. Monoclonal antibodies against recombinant parts of the ki-67 antigen (MIB-1 and M1B-3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 1992;168:357.
86. Ascoli V, Scalzo CC, Nardi F. C-erbB-2 oncoprotein immunostaining in serous effusions. Cytopathology 1993;4:207-218.
87. Walts AE, Said JW, Koeffler P. Is immunoreactivity for p53 useful in distinguishing benign from malignant effusions? Localization of p53 gene product in benign mesothelial and adenocarcinoma cells. Mod Pathol 1994;7:462-468.
88. Tawfik MS, Coleman DV. C-myc expression in exfoliated cells in serous effusions. Cytopathology 1991;2:83-92.
89. Masood S. Use of monoclonal antibody for assessment of estrogen and progesterone receptors in malignant effusions. Diagn Cytopathol 1992;8:161-166.
90. Kandylis K, Vassilomanolakis M, Baziotis N, et al. Diagostic significance of the tumour markers CHA, CA 15-3 and CA 125 in malignant effusions in breast cancer. Ann Oncol 1990;1:435- 438.
91. Pinto MM, DNA analysis of malignant effusions. Comparison with cytologic diagnosis and carcinoembryonic antigen content. Anal Quant Cytol Histol 1992;14:222-226.
92. Czerniak B, Papenhausen PR, Herz F, Koss LG. Flow cytometric identification of cancer cells in effusions with Cal monoclonal antibody. Cancer 1985;55:2783-2788.
93. Frierson HF Jr, Mills SE, Legier JF. Flow cytometric analysis of ploidy in immunohistochemically confirmed examples of malignant epithelial mesothelioma. Am J Clin Pathol 1988;90:240-243.
94. Unger KM, Raber M, Bedrossian CWM, Stein DA, Barlogie B. Analysis of pleural effusions using automated flow cytometry. Cancer 1983;52:872-877.
95. Banks ER, Jennings CD, Jacobs S, Davey DD. Comparative assessment of DNA analysis in effusions by image analysis and flow cytometry, Diagn Cytopathol 1994;10:62-67.
96. Pettersson T, Froseth B, Riska H, Klockars M. Concentration of hyaluronic acid in pleural fluid as a diagnostic aid for malignant mesothelioma. Chest 1988;94:1037-1039.
97. Imokawa M, Okabe H, Ochi Y, Kajita Y. Clinical significance ofmucin-like high molecular weight glycoprotein originated from lung cancer as tumor marker. Clin Chim Acta 1989;180:45-58.
98. Prey MU, Bedrossian CW, Masood S. The value of monoclonal antibody B72.3 for the diagnosis of breast carcinoma: experience with the first commercially available source. Hum Pathol 1991;22:598.
99. Bedrossian CWM, Bonsib S, Moran C. Differential diagnosis between mesothelioma and adenocarcinoma: a multimodal approach based on immunocytochemistry and electron microscopy. Semin Diagn Pathol 1990;9:124-132.
100. Bedrossian CWM, Gudlauggson E. Alternative techniques of cervical cancer screening. In: Groh's automated cancer screening. New York: Igaku-Shoin Medical Publishers, 1994;78-117.