Molecular features in a biphenotypic small cell sarcoma with neuroectodermal and muscle differentiation

Human Pathology

Volumn 29, Issue 2, 1998, Pages 181-184

  De Alava, Enrique ^a   Lozano, María Dolores ^b   Sola, Iosu ^b   Panizo, Angel ^b   Idoate, Miguel A ^b   Martínez Isla, Carmen ^b   Forteza, Jerónimo ^b   Sierrasesúmaga, Luis ^b   Pardo Mindán, F Javier ^b  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

^b NONE

Author keywords

Alveolar rhabdomyosarcoma; Chimeric transcript; Ewing sarcoma PNET; EWS FLI1; Malignant ectomesenchymoma; PAX3 FKHS chimeric transcript

Indexed keywords

ADOLESCENT; ARTICLE; ASPIRATION CYTOLOGY; CANCER CYTODIAGNOSIS; CASE REPORT; EWING SARCOMA; FEMALE; HUMAN; HUMAN TISSUE; NEUROECTODERM TUMOR; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; RNA ANALYSIS; SOFT TISSUE SARCOMA; SOUTHERN BLOTTING;

EID: 0031934662     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(98)90230-1     Document Type: Article

References (14)

1. Barr FG, Chatten J, D'Cruz CM, et al: Molecular assays for chromosomal translocations in the diagnosis of pediatric soft tissue tumors. JAMA 273:553-557, 1995
2. Barr FG, Galili N, Holick J, et al: Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma. Nature Genetics 3:113-117, 1993
3. Delattre O, Zucman J, Melot T, et al: The Ewing family of tumors. A subgroup of small round cell tumors defined by specific chimeric transcripts. N Engl J Med 331:294-299, 1994
4. Ladanyi M, Gerald W: Fusion of the EWS and WTI genes in the desmoplastic small round cell tumor. Cancer Res 54:2837-2840, 1994
5. de Alava E, Ladanyi M, Rosai J, Gerald WL: Detection of chimeric transcripts in desmoplastic small round cell tumor and related developmental tumors by RT-PCR. A specific diagnostic assay. Am J Pathol 147:1584-1591, 1995
6. Pfleiderer C, Zoubek A, Gruber B, et al: Detection of tumour cells in peripheral blood and bone marrow from Ewing tumour patients by RT-PCR. Int J Cancer 64:135-139, 1995
7. Parham DM: Ewing's sarcoma and related tumors, in Parham D: Pediatric Neoplasia. Morphology and Biology. Philadelphia, PA, Lippincott-Raven, 1996, pp 65-85
8. Thorner P, Squire J, Chilton-McNeill S, et al: Is the EWS/FLI-1 fusion transcript specific for Ewing sarcoma and peripheral primitive neuroectodermal tumor? A report of four cases showing this transcript in a wider range of tumor types. Am J Pathol 148:1125-1138, 1996
9. Katz RL, Quezado M, Senderowicz AM, et al: An intraabdominal small round cell neoplasm with features of primitive neuroectodermal and desmoplastic round cell tumor and a EWS-FLI1 fusion transcript. HUM PATHOL 28:502-509, 1997
10. Sorensen PHB, Shimada H, Liu XF, et al: Biphenotypic sarcomas with myogenic and neural differentiation express the Ewing's sarcoma EWS/FLI1 fusion gene. Cancer Res 55:1385-1392, 1995
11. Downing JR, Khandekar A, Shurtleff SA, et al: Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma. Am J Pathol 146:626-634, 1995
12. Whang-Peng J, Knutsen T, Theil K, et al: Cytogenetic studies in subgroups of rhabdomyosarcoma. Genes Chromosomes Cancer 5:299-310, 1992
13. Akerman M, Dreinhofer K, Rydholm A, et al: Cytogenetic studies on fine-needle aspiration samples from osteosarcoma and Ewing's sarcoma. Diagn Cytopathol 15:17-22, 1996
14. Kelly KM, Womer RB, Barr FG: Minimal residual detection in alveolar rhabdomyosarcoma using a reverse transcriptase-polymerase chain reaction. Cancer 78:1320-1327, 1996