The MxA protein levels in whole blood lysates of patients with various viral infections

Journal of Virological Methods

Volumn 70, Issue 2, 1998, Pages 183-191

  Chieux, V ^a   Hober, D ^a   Harvey, J ^b   Lion, G ^c   Lucidarme, D ^d   Forzy, G ^d   Duhamel, M ^e   Cousin, J ^e   Ducoulombier, H ^e   Wattre P ^a  

^a Centre Hospitalier et Universitaire   (France)

^b NOVARTIS PHARMA AG   (Switzerland)

^c CENTRE HOSPITALIER DE VALENCIENNES   (France)

^d Centre Hospitalier Saint Philibert GHICL   (France)

^e Centre Hospitalier Feron Vrau   (France)

Author keywords

HCV infection; Immunochemiluminescent assay; Interferon; Interferon treatment; MxA protein; Viral disease

Indexed keywords

ALPHA INTERFERON; CYTOKINE; RECOMBINANT ALPHA2B INTERFERON;

ADENOVIRUS; ADOLESCENT; ADULT; AGED; ARTICLE; CHEMOLUMINESCENCE; CHILD; CHRONIC HEPATITIS; CLINICAL ARTICLE; FEMALE; HEPATITIS C; HUMAN; MALE; NEWBORN; PRIORITY JOURNAL; PROTEIN DETERMINATION; ROTAVIRUS; SUBCUTANEOUS DRUG ADMINISTRATION; VIRUS DETECTION; VIRUS INFECTION; VIRUS LOAD;

GTP-BINDING PROTEINS; HEPATITIS C; HUMANS; PROTEINS; VIRUS DISEASES;

EID: 0031934606     PISSN: 01660934     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-0934(97)00177-8     Document Type: Article

References (29)

1. Antonelli G., Simeoni E., Solmone N., Antonelli L., Iaiani G., Dianzani F. In vitro and in vivo detection of IFN-induced MxA and MxB mRNA by RT-PCR. Eur. Cytokine Netw. 7:1996;494.
2. Baca L.M., Genis P., Kalvakolanu D., Sen G., Meltzer M.S., Zhou A., Silverman R., Gendelman E. Regulation of interferon-α-inducible cellular genes in human immunodeficiency virus-infected monocytes. J. Leukocyte Biol. 55:1994;299-309.
3. Belardelli F. Role of Interferon and other cytokines in the regulation of the immune response. APMIS. 103:1995;161-179.
4. Buffet-Janvresse C., Magard H., Robert N., Hovanessian A.G. Assay and the levels of 2′-5′ adenylate synthetase in lymphocytes of patients with viral, bacterial and autoimmune diseases. Ann. Immunol. 134:1983;247-258.
5. Buffet-Janvresse C., Vannier J.P., Laurent A.G., Robert N., Hovanessian A.G. Enhanced levels of double-stranded RNA-dependant protein kinase in peripheral blood mononuclear cells of patients with viral infections. J. Interferon Res. 6:1986;85-96.
6. Fäh J., Pavlovic J., Burg G. Expression of MxA protein in inflammatory dermatoses. J. Histochem. Cytochem. 43:1995;47-52.
7. Frese M., Kochs G., Feldmann H., Hertkorn C., Haller O. Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein. J. Virol. 2:1996;915-923.
8. Horisberger M.A. Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins. Virology. 66:1992;4705-4709.
9. Horisberger M.A., De Staritzky K. Expression and stability of the Mx protein in different tissues of mice, in response to interferon inducers or to influenza virus infection. J. Interferon Res. 9:1989;583-590.
10. Horisberger M.A., Hochkeppel K.H. IFNα induced human 78 kD protein: purification and homologies with the mouse Mx protein, production of monoclonal antibodies, and potentiation effect of IFNγ J. Interferon Res. 7:1987;331-343.
11. Jakschies D., Hochkeppel H.K., Horisberger M.A., Deicher H., von Wussow P. Correlation of the antiproliferative effect and the Mx-homologous protein induction by IFN in patients with malignant melanoma. J. Invest. Dermatol. 95:1990;238-241.
12. Jakschies D., Armbrust A., Clare K.U., Nolte H., Towbin H., Deicher H., von Wussow P. Significant difference of the MxA-protein expression in human PBL of patients with viral and bacterial infections. J. Interferon Res. 14:1994;S124.
13. Jakschies D., Zachoval R., Müller R., Manns M., Nolte K.U., Hochkepelle H.K., Horisberger M.A., Deicher H., von Wussow P. Strong transient expression of the type I Interferon-induced MxA protein in hepatitis A but not in acute hepatitis B and C. Hepatology. 19:1994;857-865.
14. Joklik, W.K., 1990. Interferons. In: Fields, B.N. (Ed.), Virology, 2nd edn. pp 383-401.
15. Oh S.K., Luhowskyj S., Witt P., Ritch P., Reitsma D., Towbin H., Horisberger M.A., Von Wussow P., Bluestein B. Quantitation of Interferon-induced Mx protein in whole blood lysates by an immunochemiluminescent assay: elimination of protease activity of cell lysates in toto. J. Immunol. Methods. 176:1994;79-91.
16. Pavlovic J., Zürcher T., Haller O., Staeheli P. Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. J. Virol. 7:1990;3370-3375.
17. Pawlotsky et al., 1995. Lippincott Raven Publishers, Philadelphia, NY.
18. Pawlotsky J.M., Hovanessian A.G., Roudot-Thoroval F., Robert N., Bouvier M., Babany G., Duval J., Dhumeaux D. Effect of alpha Interferon (IFNα) on 2′-5′ oligoadénylate synthetase activity in peripheral blood mononuclear cells of patients with chronic hepatitis C: relationship to the antiviral effect of IFNα Antimicrob. Agents Chem. 40:1996;320-324.
19. Roers A., Hochkeppel H.K., Horisberger M.A., Hovanessian A., Haller O. MxA gene expression after live virus vaccination: a sensitive marker for endogenous type I interferon. J. Infect. Dis. 169:1994;807-813.
20. Ronni T., Melen K., Malygin A., Julkunen I. Control of IFN-inducible MxA gene expression in human cells. J. Immunol. 150:1993;1715-1718.
21. Schatner A., Wallach D., Merlin G., Hahn T., Levin S., Ramot S., Revel M. Variation of (2′-5′) oligo A synthetase level in lymphocytes and granulocytes of patients with viral infections and leukemia. J. Interferon Res. 2:1981;355-361.
22. Schwemmle M., Richter M.F., Herrmann C., Nassar N., Staeheli P. Unexpected structural requirements for GTPase activity of the interferon-induced MxA protein. J. Biol. Chem. 270:1995;13518-13523.
23. Simon A., Fäh J., Haller O., Staeheli P. Interferon-regulated Mx genes are not responsive to interleukin-1, Tumor Necrosis Factor, and other cytokines. J. Virol. 65:1991;968-971.
24. Taylor J.L., Grossberg S.E. Recent progress in Interferon research: molecular mechanisms of regulation, action, and virus circumvention. Virus Res. 15:1990;1-26.
25. Towbin H., Schmitz A., Jakschies D., Von Wussow P., Horisberger M.A. A whole blood immunoassay for the Interferon-inducible human Mx protein. J. Interferon Res. 12:1992;67-74.
26. Van Der Bij W., Van Son W.J., Van Der berg A.P.M., Tegzess A.M., Torensma R. Cytomegalovirus (CMV) antigenemia: rapid diagnosis and relationship with CMV-associated clinical syndromes in renal allograft recipient. Transplant. Proc. 21:1989;2061-2064.
27. von Wussow P., Jakschies D., Hochkeppel H.K., Horisberger M.A., Hartung K., Deicher H. Mx homologous protein in mononuclear cells from patients with systemic lupus erythematosus. Arthritis Rheum. 32:1989;914-918.
28. von Wussow P., Jakschies D., Hochkeppel K.H., Fibisch C., Penner L., Deicher H. The human intracellular Mx-homologous protein is specifically induced by type I Interferons. Eur. J. Immunol. 20:1990;2015-2019.
29. Wallach D., Schatner A., Merlin G., Hahn T., Levin S., Revel M. Assay of an interferon-induced enzyme in white blood cells as a diagnostic aid in viral diseases. Lancet. 2:1981;497-499.