Reliable genotyping of the G-20210-A mutation of coagulation factor II (prothrombin)

Clinical Chemistry

Volumn 44, Issue 2, 1998, Pages 349-351

  Danneberg, Jan ^a   Abbes, André P ^b   Bruggeman, Ben J M ^b   Engel, Henk ^b   Gerrits, Jan ^a   Martens, Alexander ^a  

^a TWENTEBORG HOSPITAL   (Netherlands)

^b Sophia Hospital   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PROTHROMBIN; SERINE PROTEINASE;

ALLELE; ARTICLE; CHROMOSOME 11; DEEP VEIN THROMBOSIS; DNA DETERMINATION; GENE AMPLIFICATION; GENE MAPPING; GENE MUTATION; GENETIC CODE; GENOTYPE; POLYMERASE CHAIN REACTION; PREVALENCE; RELIABILITY; RISK FACTOR;

EID: 0031934504     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/44.2.349     Document Type: Article

References (7)

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3. Dang QD, Vindigni A, di Cera E. An allosteric switch controls the procoagulant and anticoagulant activities of thrombin. Proc Natl Acad Sci U S A 1995;92: 5977.
4. Degen SJF, Davie EW. Nucleotide sequence of the gene for human prothrombin. Biochemistry 1987;26:6165-77.
5. Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RTA, Hamerton JL. Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. Somat Cell Mol Genet 1987;13:285-92.
6. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996;88:3698-703.
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