Construction of an isogenic leukotoxin deletion mutant of Pasteurella haemolytica serotype 1: Characterization and virulence

Microbial Pathogenesis

Volumn 24, Issue 1, 1998, Pages 37-46

  Tatum, Fred M ^a   Briggs, Robert E ^a   Sreevatsan, Srinand S ^b   Zehr, Emile S ^a   Hsuan, Shih Ling ^b   Whiteley, Laurence O ^c   Ames, Trevor R ^b   Maheswaran, Samuel K ^b,d  

^a NATIONAL ANIMAL DISEASE CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c PROCTER AND GAMBLE COMPANY   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Characterization; Leukotoxin negative mutants; Pasteurella haemolytica

Indexed keywords

LEUKOTOXIN; VIRULENCE FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CATTLE; CONTROLLED STUDY; DELETION MUTANT; LUNG INJURY; MANNHEIMIA HAEMOLYTICA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALIA; BACTERIA (MICROORGANISMS); BOS TAURUS; BOVINAE; MANNHEIMIA HAEMOLYTICA SEROTYPE 1; NEGIBACTERIA; OVIS ARIES; PASTEURELLA;

EID: 0031934481     PISSN: 08824010     EISSN: None     Source Type: Journal    
DOI: 10.1006/mpat.1997.0181     Document Type: Article

References (31)

1. Frank GH. Pasteurellosis of cattle. In: Adlam C, Rutter JM, Eds. Pasteurella and pasteurellosis. Academic Press, 1989: 197-222.
2. Whiteley LO, Maheswaran SK, Weiss DJ, Ames TR, Kannan MS. Pasteurella haemolytica A1 and bovine respiratory disease: pathogenesis. J Vet Inter Med 1992; 6: 11-22.
3. Confer AW, Panciera RJ, Clinkenbeard KD, Mosier DA. Molecular aspects of virulence of Pasteurella haemolytica. Can J Vet Res 1990; 54: S48-52.
4. Coote JG. Structural and functional relationships among the RTX toxin determinants of Gram-negative bacteria. FEMS Microbiol Rev 1992; 88: 137-62.
5. Kaehler KL, Markham RJF, Muscoplat CC, Johnson DW. Evidence of species specificity in the cytocidal effects of Pasteurella haemolytica. Infect Immun 1980; 30: 615-18.
6. Clinkenbeard KD, Upton ML. Lysis of bovine platelets by Pasteurella haemolytica leukotoxin. Am J Vet Res 1991; 52: 453-7.
7. Highlander SK, Chidambaram M, Engler MJ, Weinstock GM. DNA sequence of the Pasteurella haemolytica leukotoxin gene cluster. DNA 1989; 8: 15-28.
8. Strathdee CA, Lo RYC. Cloning, nucleotide sequence, and characterization of genes encoding the secretion function of Pasteurella haemolytica leukotoxin determinant. J Bact 1989; 171: 916-28.
9. Highlander SK, Engler MJ, Weinstock GM. Secretion and expression of the Pasteurella haemolytica leukotoxin. J Bact 1990; 172: 2343-50.
10. Ames TR, Markham RJF, Asibo-Opuda J, Leininger JR, Maheswaran SK. Pulmonary response to intratracheal challenge with Pasteurella haemolytica and Pasteurella multocida. Can J comp Med 1985; 49: 395-400.
11. Whiteley LO, Maheswaran SK, Weiss DJ, Ames TR. Immunohistochemical localization of Pasteurella haemolytica A1-derived endotoxin, leukotoxin and capsular polysaccharide in experimental bovine pasteurella pneumonia. Vet Pathol 1990; 27: 150-61.
12. Petras SF, Chidambaram M, Illyes EF, Froshauer S, Weinstock GM, Reese CP. Antigenic and virulence properties of Pasteurella haemolytica leukotoxin mutants. Infect Immun 1995; 63: 1033-9.
13. Maheswaran SK, Whiteley LO, Townsend EL, Ames TR, Weiss DJ, Yoo HS, Gonzalez C, Kannan MS. Leukotoxin as a virulent factor of Pasteurella haemolytic. Proc Seventh World Buitrics Congress 1992; 3: 199-201.
14. Czyprynski CJ, Noel EJ, Ortiz-Carranza O, Srikumaran S. Activation of bovine neutrophils by partially purified Pasteurella haemolytica leukotoxin. Infect Immun 1991; 59: 3126-33.
15. Maheswaran SK, Weiss DJ, Kannan MS, Townsend EL, Reddy KR, Whiteley LO, Srikumaran S. Effects of Pasteurella haemolytica A1 leukotoxin on bovine neutrophils: degranulation, and generation of oxygen-derived free radicals. Vet Immunol Immunopathol 1992; 33: 51-68.
16. Majury AL, Schewen PE. The effect of Pasteurella haemolytica A1 leukotoxic culture supernate on the in vitro proliferative response of bovine lymphocytes. Vet Immunol Immunopathol 1991; 29: 41-56.
17. Henricks PAJ, Binkhorst GJ, Drijver AA, Nijkamp FP. Pasteurella haemolytica leukotoxin enhances production of leukotriene B4 and 5-hydroxyeicosatetraenoic acid by bovine polymorphonuclear leukocytes. Infect Immun 1992; 60: 3238-43.
18. Clinkenbeard KD, Clark CR, Hague CM, Clinkenbeard P, Srikumaran S, Morton RJ. Pasteurella haemolytic leukotoxin-induced synthesis of eicosanoids by bovine neutrophils in vitro. J Leukocyte Biol 1994; 56: 644-9.
19. Yoo HS, Rajagopal BS, Maheswaran SK, Ames TR. Purified Pasteurella haemolytica leukotoxin induces expression of inflammatory cytokines from bovine alveolar macrophages. Microb Pathog 1995; 18: 237-52.
20. Maheswaran SK, Kannan MS, Weiss DJ, Reddy KR, Townsend EL, Yoo HS, Lee BW, Whiteley LO. Enhancement of neutrophil-mediated injury to bovine pulmonary endothelial cells by Pasteurella haemolytica leukotoxin. Infect Immun 1993; 61: 2618-25.
21. Chidambaram M, Sharma B, Petras SF, Reese CP, Froshauer S, Weinstock GM. Isolation of Pasteurella haemolytica leukotoxin mutants. Infect Immun 1995; 63: 1027-32.
22. Briggs RE, Tatum FM, Casey TA, Frank GH. Characterization of a restriction endonuclease, Pha1, from Pasteurella haemolytica serotype A1 and protection of heterologous DNA by a cloned PhaI methyltransferase gene. Applied Environ Microbiol 1994; 60: 2006-10.
23. Tatum FM, Briggs RE, Hailing SM. Molecular cloning and nucleotide sequencing and construction of an aroA mutant of Pasteurella haemolytica serotype A1. Applied Environ Microbiol 1994; 60: 2011-16.
24. Murphy GL, Whitworth LC, Clinkenbeard KD, Clinkenbeard PA. Hemolytic activity of the Pasteurella haemolytica leukotoxin. Infect Immun 1995; 63: 3209-12.
25. Maniatis T, Fritsch EF, Sambrook J. Molecular Cloning: a Laboratory Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press, 1982.
26. Penaredondo MV, Maheswaran SK, Whiteley LO, Ames TR, Leininger JR. Production and partial characterization of monoclonal antibodies to Pasteurella haemolytica A1 capsular polysaccharide and lipopolysaccharide. Am J Vet Res 1988; 49: 1962-8.
27. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitro-cellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979; 76: 4350-4.
28. Gentry MJ, Srikumaran S. Neutralizing monoclonal antibodies to Pasteurella haemolytica leukotokin affinity - purify the toxin from crude culture supernatants. Microb Pathog 1991; 10: 411-17.
29. Srinand S, Hsuan SL, Yoo HS, Ames TR, Maheswaran SK, Werdin RE. Comparative evaluation of antibodies induced by commercial Pasteurella haemolytica vaccines using solid phase immunoassays. Vet Microbiol 1996; 49: 181-95.
30. Yoo HS, Maheswaran SK, Srinand S, Ames TR, Suresh M. Increased tumor necrosis factor-α and interleukin-1β expression in the lungs of calves with experimental pneumonic pasteurellosis. Vet Immunol Immunopathol 1995; 49: 15-28.
31. Gogolewski RP, Leathers CW, Liggit HD, Corbeil LB. Experimental Haemophilus somnus pneumonia in calves and immunoperoxidase localization of bacteria. Vet Pathol 1987; 24: 250-6.