PKA inhibitor, H-89, affects the intracellular transit of regulated secretory proteins in rat lacrimal glands

American Journal of Physiology - Cell Physiology

Volumn 274, Issue 1 43-1, 1998, Pages

  Robin, P ^a   Rossignol, B ^a   Raymond, M N ^a,b  

^a CNRS   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Protein kinase A; Protein secretion; Protein sorting; Regulation of intracellular transit

Indexed keywords

CALPHOSTIN C; CHELERYTHRINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE C; SECRETORY PROTEIN;

ANIMAL CELL; ARTICLE; DRUG EFFECT; ENZYME INHIBITION; EXTRACELLULAR CALCIUM; GOLGI COMPLEX; INTRACELLULAR TRANSPORT; LACRIMAL GLAND; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN TRANSPORT; RAT; REGULATORY MECHANISM; TRANSPORT KINETICS;

ANIMALIA;

EID: 0031934457     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1998.274.1.c262     Document Type: Article

References (43)

1. Albrecht, D. E., and J. G. Tidball. Platelet-derived growth factor-stimulated secretion of basement membrane proteins by skeletal muscle occurs by tyrosine kinase-dependent and -independent pathways. J. Biol. Chem. 272: 2236-2244, 1997.
2. Arvan, P., and J. D. Castle. Phasic release of newly synthesized secretory proteins in the unstimulated rat exocrine pancreas. J. Cell Biol. 104: 243-252, 1987.
3. Arvan, P., R. Kuliawat, D. Prabakaran, A.-M. Zavacki, D. Elahi, S. Wang, and D. Pilkey. Protein discharge from immature secretory granules displays both regulated and constitutive characteristics. J. Biol. Chem. 266: 14171-14174, 1991.
4. Bauerfeind, R., and W. B. Huttner. Biogenesis of constitutive secretory vesicles, secretory granules and synaptic vesicles. Curr. Opin. Cell Biol. 5: 628-635, 1993.
5. Buccione, R., S. Bannykh, I. Santone, M. Baldassarre, F. Facchiano, Y. Bozzi, G. Di Tullio, A. Mironov, A. Luini, and M. A. De Matteis. Regulation of constitutive exocytic transport by membrane receptors. J. Biol. Chem. 271: 3523-3533, 1996.
6. Burgess, T. L., and R. B. Kelly. Constitutive and regulated secretion of proteins. Annu. Rev. Cell Biol. 3: 243-293, 1987.
7. Cardone, M. H., B. L. Smith, W. Song, D. Mochly-Rosen, and K. E. Mostov. Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells. J. Cell Biol. 124: 717-727, 1994.
8. Chanat, E., U. Weiss, W. B. Huttner, and S. A. Tooze. Reduction of the disulfide bond of chromogranin B (secretogranin I) in the trans-Golgi network causes its missorting to the constitutive secretory pathway. EMBO J. 12: 2159-2168, 1993.
9. Chijiwa, T., A. Mishima, M. Hagiwara, M. Sano, K. Hayashi, T. Inoue, K. Naito, T. Toshioka, and H. Hidaka. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J. Biol. Chem. 265: 5267-5272, 1990.
10. Clegg, C. H., M. S. Abrahamsen, J. L. Degen, D. R. Morris, and G. S. McKnight. Cyclic AMP-dependent protein kinase controls basal gene activity and steroidogenesis in Y1 adrenal tumor cells. Biochemistry 31: 3720-3726, 1992.
11. Colomer, V., K. Lal, T. C. Hoops, and M. J. Rindler. Exocrine granule specific packaging signals are present in the polypeptide moiety of the pancreatic granule membrane protein GP2 and in amylase: implication for protein targeting to secretory granules. EMBO J. 13: 3711-3719, 1994.
12. fat mice. Cell 88: 73-83, 1997.
13. 2+ signalling in articular chondrocytes. Biochem. J. 318: 569-573, 1996.
14. Dartt, D. A. Signal transduction and control of lacrimal gland protein secretion: a review. Curr. Eye Res. 8: 619-636, 1989.
15. Davidson, H. W., and W. E. Balch. Differential inhibition of multiple vesicular transport steps between the endoplasmic reticulum and trans Golgi network. J. Biol. Chem. 268: 4216-4226, 1993.
16. Davidson, H. W., C. H. McGowan, and W. E. Balch. Evidence for the regulation of exocytic transport by protein phosphorylation. J. Cell Biol. 116: 1343-1355, 1992.
17. De, P. K. Tissue distribution of constitutive and induced soluble peroxidase in rat: purification and characterization from lacrimal gland. Eur. J. Biochem. 206: 59-67, 1992.
18. De Camilli, P., M. Moretti, S. D. Donini, U. Walter, and S. M. Lohmann. Heterogeneous distribution of the cAMP receptor protein RII in the nervous system: evidence for its intracellular accumulation on microtubules, microtubule-organizing centers, and in the area of the Golgi complex. J. Cell Biol. 103: 189-203, 1986.
19. Griffiths, G., R. Hollinshead, B. A. Hemmings, and E. A. Nigg. Ultrastructural localization of the regulatory (RII) subunit of cyclic AMP-dependent protein kinase to subcellular compartments active in endocytosis and recycling of membrane receptors. J. Cell Sci. 96: 691-703, 1990.
20. Griffiths, G., S. Pfeiffer, K. Simons, and K. Matlin. Exit of newly synthesized membrane proteins from the trans cisterna of the Golgi complex to the plasma membrane. J. Cell Biol. 101: 949-964, 1985.
21. Halban, P. A., and J.-C. Irminger. Sorting and processing of secretory proteins. Biochem. J. 299: 1-18, 1994.
22. Hansen, S. H., and J. E. Casanova. Gsα stimulates transcytosis and apical secretion in MDCK cells through cAMP and protein kinase A. J. Cell Biol. 126: 677-687, 1994.
23. Herbert, J. M., J. M. Augereau, J. Gleye, and J. P. Maffrand. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 172: 993-999, 1990.
24. Herrero, I., and J. Sanchez-Prieto. cAMP-dependent facilitation of glutamate release by β-adrenergic receptors in cerebrocortical nerve terminals. J. Biol. Chem. 271: 30554-30560, 1996.
25. Herzog, V., H. Sies, and F. Miller. Exocytosis in secretory cells of rat lacrimal gland: peroxidase release from lobules and isolated cells upon cholinergic stimulation. J. Cell Biol. 70: 692-706, 1976.
26. Huang, X. F., and P. Arvan. Formation of the insulin-containing secretory granule core occurs within immature β-granules. J. Biol. Chem. 269: 20838-20844, 1994.
27. Jilling, T., and K. L. Kirk. Cyclic AMP and chloride-dependent regulation of the apical constitutive secretory pathway in colonic epithelial cells. J. Biol. Chem. 271: 4381-4387, 1996.
28. Kobayashi, E., H. Nakano, M. Morimoto, and T. Tamaoki. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 159: 548-553, 1989.
29. Kornfeld, R., and S. Kornfeld. Assembly of asparagine-linked oligosaccharides. Annu. Rev. Biochem. 54: 631-664, 1985.
30. Kuliawat, R., and P. Arvan. Protein targeting via the "constitutive-like" secretory pathway in isolated pancreatic islets: passive sorting in the immature granule compartment. J. Cell Biol. 118: 521-529, 1992.
31. 2+ effects. Am. J. Physiol. 246 (Cell Physiol. 15): C37-C44, 1984.
32. Muller, L., A. Barret, R. Picart, and C. Tougard. Proteolytic processing of sulfated secretogranin II in the trans-Golgi network of GH3B6 prolactin cells. J. Biol. Chem. 272: 3669-3673, 1997.
33. Muniz, M., M. Alonso, J. Hidalgo, and A. Velasco. A regulatory role for cAMP-dependent protein kinase in protein traffic along the exocytic route. J. Biol. Chem. 271: 30935-30941, 1996.
34. Nigg, E. A., G. Schäfer, H. Hilz, and H. M. Eppenberger. Cyclic-AMP-dependent protein kinase type II is associated with the Golgi complex and with centrosomes. Cell 41: 1039-1051, 1985.
35. Ohashi, M., and W. B. Huttner. An elevation of cytosolic protein phosphorylation modulates trimeric G-protein regulation of secretory vesicle formation from the trans-Golgi network. J. Biol. Chem. 269: 24897-24905, 1994.
36. Pimplikar, S. W., and K. Simons. Activators of protein kinase A stimulate apical but not basolateral transport in epithelial Madin-Darby canine kidney cells. J. Biol. Chem. 269: 19054-19059, 1994.
37. Robin, P., B. Rossignol, and M.-N. Raymond. Recovery of protein secretion after brefeldin A treatment of rat lacrimal glands: effect of cAMP. Am. J. Physiol. 271 (Cell Physiol. 40): C783-C793, 1996.
38. Saraste, J., and E. Kuismanen. Pre- and post-Golgi vacuoles operate in the transport of Semliki Forest virus membrane glycoproteins to the cell surface. Cell 38: 535-549, 1984.
39. Simon, J.-P., I. E. Ivanov, M. Adesnik, and D. D. Sabatini. The production of post-Golgi vesicles requires a protein kinase C-like molecule, but not its phosphorylating activity. J. Cell Biol. 135: 355-370, 1996.
40. Sugiyama, H., P. Chen, M. G. Hunter, and M. V. Sitkovsky. Perturbation of the expression of the catalytic subunit Ca of cyclic AMP-dependent protein kinase inhibits TCR-triggered secretion of IL-2 by T helper hybridoma cells. J. Immunol. 158: 171-179, 1997.
41. Sugiyama, H., P. Chen, M. Hunter, R. Taffs, and M. Sitkovsky. The dual role of the cAMP-dependent protein kinase Cα subunit in T-cell receptor-triggered T-lymphocytes effector functions. J. Biol. Chem. 267: 25256-25263, 1992.
42. Von Zastrow, M., and J. D. Castle. Protein sorting among two distinct export pathways occurs from the content of maturing exocrine storage granules. J. Cell Biol. 105: 2675-2684, 1987.
43. Xu, H., P. Greengard, and S. Gandy. Regulated formation of Golgi secretory vesicles containing Alzheimer β-amyloid precursor protein. J. Biol Chem. 270: 23243-23245, 1995.