Human embryonic spinal cord grafts in adult rat spinal cord cavities: Survival, growth, and interactions with the host

Experimental Neurology

Volumn 149, Issue 1, 1998, Pages 262-276

  Åkesson, Elisabet ^a   Kjaeldgaard, Anders ^a   Seiger, Åke ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cavity; Embryonic; Human; Intraspinal; Spinal cord; Transplant

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; SEROTONIN; THY 1 ANTIGEN; TYROSINE 3 MONOOXYGENASE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EXPERIMENTAL TRANSPLANTATION; GRAFT SURVIVAL; HUMAN; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL CORD INJURY;

EID: 0031933637     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1997.6668     Document Type: Article

References (60)

1. Acton R. T., Addis J., McClain C. L. D., Bridgers W. F. Association of Thy-1 differentiation alloantigen with synaptic complexes isolated from mouse brain. Proc. Natl. Acad. Sci. USA. 75:1978;3283-3287.
2. Anderson D. K., Reier P. J., Wirth E. D. I., Theele D. P., Brown S. A. Transplants of fetal CNS grafts in chronic compression lesions of the adult cat spinal cord. Restorative Neurol. Neurosci. 2:1991;309-325.
3. Anton H. A., Schweigel J. F. Posttraumatic syringomyelia: The British Columbia experience. Spine. 11:1986;865-868.
4. Barclay A. N. Localization of the Thy-1 antigen in the cerebellar cortex of rat brain by immunofluorescence. J. Neurochem. 32:1979;1249-1257.
5. Barclay A. N., Hyde'n H. Localization of the Thy-1 antigen in rat brain and spinal cord by immunofluorescence. J. Neurochem. 31:1978;1375-1391.
6. Barclay A. N., Letarte-Muirhead M., Williams A. F., Faulkes R. A. Chemical characterization of the Thy-1 glycoproteins from the membranes of rat thymocytes and brain. Nature. 263:1976;563-567.
7. Barnett, Foster, Hudgson. Syringomyelia. 1973;Saunders, London.
8. Bernstein J. J., Goldberg W. J. Fetal spinal cord homografts ameliorate the severity of lesion-induced hind limb behavioral deficits. Exp. Neurol. 98:1987;633-644.
9. Blight A. R. Cellular morphology of chronic spinal cord injury in the cat: Analysis of myelinated axons by line sampling. Neuroscience. 10:1983;521-542.
10. Bolin L. M., Rouse R. V. Localization of Thy-1 expression during postnatal development of the mouse cerebellar cortex. J. Neurocyt. 15:1986;29-36.
11. Bregman B. S., Kunkel-Bagden E., Reier P. J., Dai H. D., McAtee M., Gao D. Recovery of function after spinal cord injury: Mechanisms underlying transplant-mediated recovery of function differ after spinal cord injury in newborn and adult rats. Exp. Neurol. 123:1993;3-16.
12. Bregman B. S., Reier P. J. Neural tissue transplants rescue axotomized rubrospinal cells from retrograde death. J. Comp. Neurol. 244:1986;86-95.
13. Bunge M. B., Holets V. R., Bates M. L., Clarke T. S., Watson B. D. Characterization of photochemically induced spinal cord injury in the rat by light and electron microscopy. Exp. Neurol. 127:1994;76-93.
14. Cajal S. R. Y. Degeneration and Regeneration of the Nervous System. 1928;Oxford Univ. Press, London.
15. Cameron T., Prado R., Watson B. D., Gonzalez-Carvajal M., Holets V. R. Photochemically induced cystic lesion in the rat spinal cord. Exp. Neurol. 109:1990;214-223.
16. Caroni P., Schwab M. Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading. J. Cell Biol. 106:1988;1281-1288.
17. Coons A. H. Fluorescent antibody methods. General Cytochemical Methods. 1958;Academic Press, New York. p. 399-422.
18. Das G. D. Neural transplantation in the spinal cord of adult rats: Conditions, survival, cytology, and connectivity of the transplant. J. Neurol. Sci. 62:1983;191-210.
19. David S., Aguayo A. J. Axonal elongation into peripheral nervous system bridges after central nervous system injury in adult rats. Science. 214:1981;931-933.
20. England M. A. A Colour Atlas of Life before Birth. 1990;Hazell, Aylesbury, Bucks.
21. Euler M. V., Seiger Å., Sundström E. Clip compression injury in the spinal cord: A correlative study of neurological and morphological alterations. Exp. Neurol. 145:1997;1-9.
22. Euler M. V., Sundström E., Seiger Å. Morphological characterization of the evolving rat spinal cord injury after photochemically induced ischemia. Acta Neuropathol. 94:1997;232-239.
23. Festing M. F., May D., Connors D., Lovell D., Sparrow S. An athymic nude mutation in the rat. Nature. 274:1978;365-366.
24. Fields K. L., Brockes J. D., Mirsky R., Wendon L. M. B. Cell surface markers for distinguishing different types of rat dorsal ganglion cells in culture. Cell. 14:1978;43-51.
25. Granholm A.-C., Almqvist P., Seiger Å., Olson L. Thy-1-like immunoreactivity in human brain during development. Brain Res. Bull. 17:1986;107-115.
26. Harris-Warrick R. M., MacPhee J. C., Filler J. A. Distribution of serotonergic neurons and processes in the lamprey spinal cord. Neuroscience. 14:1985;1127-1140.
27. Henschen A., Hökfeldt T., Elde R., Fahrenkrug J., Frey P., Terenius L., Olson L. Expression of eight neuropeptides in intraocular spinal cord grafts: Organotypical and disturbed patterns as evidenced by immunohistochemistry. Neuroscience. 26:1988;193-213.
28. Henschen A. F., Strömberg I., Bygdeman M., Dahl D., Hoffer B., Seiger Å., Olson L. Human fetal spinal cord xenografts survive in the eye of athymic nude rat hosts. Exp. Brain Res. 75:1989;317-326.
29. Houlé J. D., Reier P. J. Transplantation of fetal spinal cord tissue into the chronically injured adult rat spinal cord. J. Comp. Neurol. 269:1988;535-547.
30. Howland D. R., Bregman B. S., Tessler A., Goldberger M. Transplants enhance locomotion in neonatal kittens whose spinal cords are transected: A behavioral and anatomical study. Exp. Neurol. 135:1995;123-145.
31. Jakeman L. B., Reier P. J. Axonal projections between fetal spinal cord transplants and the adult rat spinal cord: A neuroanatomical tracing study of local interactions. J. Comp. Neurol. 307:1991;311-334.
32. Jakeman L. B., Reier P. J., Bregman B. S., Wade E. B., Dailey M., Kastner R. J., Himes B. T., Tessler A. Differentiation of gelatinosa-like regions in intraspinal and intracerebral transplants of embryonic spinal cord tissue in the rat. Exp. Neurol. 103:1989;17-33.
33. Kao C. C., Chang L. W. The mechanism of spinal cord cavitation following spinal cord transection. 1. A correlated histochemical study. J. Neurosurg. 46:1977;197-209.
34. Kapfhammer J. P., Schwab M. E., Schneider G. E. Antibody neutralization of neurite growth inhibitors from oligodendrocytes results in expanded pattern of postnatally sprouting retinocollicular axons. J. Neurosci. 12:1992;2112-2119.
35. Kozlova E. N., Seiger Å., Aldskogius H. Human dorsal root ganglion neurons from embryonic donors extend axons into the host rat spinal cord along laminin-rich peripheral surroundings of the dorsal root transitional zone. J. Neurocytology. 1997.
36. Kozlova E. N., Strömberg I., Bygdeman M., Aldskogius H. Peripherally grafted human dorsal root ganglion cells extend axons into the spinal cord of adult host rats by circumventing dorsal root entry zone astrocytes. NeuroReport. 6:1995;269-272.
37. Kruger S., Sievers J., Hansen C., Sadler M., Berry M. Three morphologically distinct types of interface develop between adult host and fetal brain transplants: implications for scar formation in the adult central nervous system. J. Comp. Neurol. 249:1986;113-116.
38. Kunkel-Bagden E., Bregman B. S. Spinal cord transplants enhance the recovery of locomotor function after spinal cord injury at birth. Exp. Brain Res. 81:1990;25-34.
39. Milhorat T. H., Capocelli A. L., Anzil A. P., Kotzen R. M., Milhorat R. Pathological basis of spinal cord cavitation in syringomyelia: Analysis of 105 autopsy cases. J. Neurosurg. 82:1995;802-812.
40. Morris R. J., Beech J. N., Barber P. C., Raisman G. Early stages of purkinje cell maturation demonstrated by Thy-1 immunohistochemistry on postnatal rat cerebellum. J. Neurocyt. 14:1985;427-452.
41. Motte C. L., Johns D. R., Lanerolle N. C. D. Immunohistochemical evidence of indolamine neurons in monkey spinal cord. J. Comp. Neurol. 206:1982;359-370.
42. Noble L. J., Wrathall J. R. Correlative analyses of lesion development and functional status after graded spinal cord contusive injuries in the rat. Exp. Neurol. 103:1989;34-40.
43. Nothias F., Peschanski M. Homotypic fetal transplants into an experimental model of spinal cord neurodegeneration. J. Comp. Neurol. 301:1990;520-534.
44. Olson L., Strömberg I., Bygdeman M., Granholm A. C., Hoffer B., Freedman R., Seiger Å. Human fetal tissues grafted to rodent hosts: Structural and functional observations of brain, adrenal, and heart tissues in oculo. Exp. Brain Res. 67:1987;163-178.
45. Olson L., Strömberg I., Bygdeman M., Henschen A., Hoffer B., Granholm L., Almqvist P., Dahl D., Oertel W., Seiger Å. Human fetal cortices and spinal cord transplanted to the anterior chamber of immunodeficient nude rats: Immunohistochemical studies. Gash D. M., Sladek J. R. Progress in Brain Research. 1988;583-590 Elsevier, Amsterdam.
46. Patel U., Bernstein J. J. Growth, differentiation, and viability of fetal rat cortical and spinal cord implants into adult rat spinal cord. J. Neurosci. 9:1983;303-310.
47. Reier P. J., Bregman B. S., Wujek J. R. Intraspinal transplantation of embryonic spinal cord tissue in neonatal and adult rats. J. Comp. Neurol. 247:1986;275-296.
48. Reier P. J., Houlé J. D., Jakeman L., Winialski D., Tessler A. Transplantation of fetal spinal cord tissue into acute and chronic hemisection and contusion lesions of the adult rat spinal cord. Gash D. M., Sladek J. R. Progress in Brain Research. 1988;173-179 Elsevier, Amsterdam.
49. Savio T., Schwab M. Rat CNS white matter, but not gray matter, is nonpermissive for neuronal cell adhesion and fiber outgrowth. J. Neurosci. 9:1989;1126-1133.
50. Schnell L., Schwab M. E. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature. 343:1990;269-272.
51. Schnell L., Schwab M. E. Sprouting and regeneration of lesioned corticospinal tract fibers in the adult rat spinal cord. Eur. J. Neurosci. 5:1993;1156-1171.
52. Schwab M. E. Myelin-associated inhibitors of neurite growth. Exp. Neurol. 109:1990;2-5.
53. Seiger Å., Almqvist P., Granholm A.-C., Olson L. On the localization of Thy-1 like immunoreactivity in the rodent and human nervous system. Med. Biol. 64:1986;109-117.
54. Squier M. V., Lehr R. P. Post-traumatic syringomyelia. J. Neurol. Neurosurg. Psychiat. 57:1994;1095-1098.
55. Stichel C. C., Wunderlich G., Schwab M. E., Muller H. W. Clearance of myelin constituents and axonal sprouting in the transected postcommissural fornix of the adult rat. Eur. J. Neurosci. 7:1995;401-411.
56. Stokes B. T., Reier P. J. Fetal grafts alter chronic behavioral outcome after injury to the adult rat spinal cord. Exp. Neurol. 116:1992;1-12.
57. Strömberg I., Bygdeman M., Goldstein M., Seiger Å., Olson L. Human fetal substantia nigra grafted to the dopamine-denervated striatum of immunosuppressed rats: evidence for functional reinnervation. Neurosci. Lett. 71:1986;271-276.
58. Vos J. G., Berkvens J. M., Kruijt B. C., Kruizinga W., Steerenberg P. The athymic nude rat. II. Immunological characteristics. Clin. Immunol. Immunopathol. 15:1980;229-237.
59. Wictorin K., Björklund A. Axon outgrowth from grafts of human embryonic spinal cord in the lesioned adult rat spinal cord. NeuroReport. 3:1992;1045-1048.
60. Wictorin K., Brundin P., Gustavii B., Lindvall O., Björklund A. Reformation of long axon pathways in adult rat CNS by human forebrain neuroblasts. Nature. 347:1990;556-558.