Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line

Journal of Pharmacology and Experimental Therapeutics

Volumn 284, Issue 2, 1998, Pages 500-507

  Kovacs, Ildiko ^a   Yamamura, Henry I ^a,b   Waite, Sue L ^a   Varga, Eva V ^a   Roeske, William R ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; ACETYLCHOLINE; ATROPINE; CARBACHOL; CHLORPROMAZINE; CYCLIC AMP; DECAMETHONIUM; DEXETIMIDE; DIFENIDOL; FORSKOLIN; GALLAMINE; HEMICHOLINIUM 3; HIMBACINE; IMIPRAMINE; INOSITOL PHOSPHATE; LEVETIMIDE; LIGAND; METHOCTRAMINE; MUSCARINIC M2 RECEPTOR; OTENZEPAD; OXOTREMORINE; PIRENZEPINE; PROCAINAMIDE; QUINIDINE; QUINUCLIDINYL BENZILATE; TUBOCURARINE CHLORIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SPECIFICITY; GENE; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR CLONING; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANIMALS; CARBACHOL; CLONING, MOLECULAR; CYCLIC AMP; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; PHOSPHATIDYLINOSITOLS; RADIOLIGAND ASSAY; RATS; RECEPTORS, MUSCARINIC; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY;

EID: 0031933508     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Akiba I , Kubo T, Maeda A, Bujo H, Naka J, Mishina M and Numa S (1988) Primary structure of porcine muscarinic acetylcholine receptor III and antagonist binding studies. FEBS Lett 235:257-261.
2. Ashkenazi A, Winslow JW, Peralta EG, Peterson GL, Schimerlik MI, Capon DJ and Ramachandran J (1987) A single M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover. Science 238:672-675.
3. Berridge MJ, Downes CP and Hanley MR (1982) Lithium amplifies agonist dependent phosphatidylinositol responses in brain and salivary gland. Biochem J 206:587-595.
4. Bolden C, Cusack B and Richelson E (1992) Antagonism by antimuscarinic and neuroleptic compounds at five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells. J Pharmacol Exp Ther 260:576-580.
5. Bonner TI, Buckley NJ, Young AC and Brann MR (1987) Identification of a family of muscarinic acetylcholine receptor genes. Science 237:527-532.
6. Bonner TI, Young AC, Brann MR and Buckley NJ (1988) Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. Neuron 1:403-410.
7. Buckley NJ, Bonner TI, Buckley CM and Brann MR (1989) Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol Pharmacol 35:469-476.
8. Camps M, Carozzi A, Schnabel P, Scheer A, Parker PJ and Gierschik P (1992) Isozyme-selective stimulation of phospholipase C-beta 2 by G-protein beta gamma-subunits. Nature 360:684-686.
9. i) and the concentration of inhibitor which causes 50 percent inhibition. Biochem Pharmacol 22:3099-3108.
10. Fields JZ, Roeske WR, Morkin E and Yamamura HI (1978) Cardiac muscarinic cholinergic receptors. J Biol Chem 253:3251-3258.
11. Gilman AG (1970) A binding assay for adenosine 3′,5′-cyclic monophosphate. Proc Natl Acad Sci USA 67:305-312.
12. Giraldo E, Micheletti R, Montagna E, Giachetti A, Vigano MA, Ladinsky H and Melchiorre C (1988) Binding and functional characterization of the cardioselective muscarinic antagonist methoctramine. J Pharmacol Exp Ther 244:1016-1020.
13. Gocayne J, Robinson DA, Fitzgerald MG, Chung F-Z, Kerlavage AR, Lenter K-U, Lai J, Wang C-D, Fraser CM and Venter JC (1987) Primary structure of rat cardiac β-adrenergic and muscarinic cholinergic receptors obtained by automated DNA sequence analysis: Further evidence for a multigene family. Proc Natl Acad Sci USA 84:8296-8300.
14. Gunning P, Leavitt J, Muscat G, Ng SY and Kedes L (1987) A human β-actin expression vector system directs high-level accumulation of antisense transcripts. Proc Natl Acad Sci USA 84:4831-4835.
15. Graham FL and Van der Eb AJ (1973) A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-59.
16. Hammer R, Berrie CP, Birdsall NJM, Burgen ASV and Hulme EC (1980) Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature 283:90-92.
17. Ja kubik J, Bacakova L, El-Fakahany EE and Tucek S (1995) Constitutive activity of M1-M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists. FEBS Lett 377:275-279.
18. Kubo T, Fukuda K, Mikami A, Maeda A, Takahashi H, Mishina M, Haga K, Ichiyama A, Kangawa K, Kojima M, Matsuo H, Hiroshe T and Numa S (1986a) Cloning sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor. Nature 323:411-416.
19. Kubo T, Maeda A, Sugimoto K, Akiba I, Mikami A, Takahashi H, Haga T, Haga K, Ichiyama A, Kangawa K, Matsuo H, Mishina M, Hiroshe T and Numa S (1986b) Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence. FEBS Lett 209:367-372.
20. Lai J, Bloom JW, Yamamura HI and Roeske WR (1990) Amplification of the rat m2 muscarinic receptor gene by the polymerase chain reaction: Functional expression of the m2 muscarinic receptor. Life Sci 47:1001-1013.
21. Lechleiter J, Hellmiss R, Duerson K, Ennulat D, David N, Clapham D and Peralta E (1990) Distinct sequence elements control the specificity of G-protein activation by muscarinic acetylcholine receptor subtypes. EMBO J 9:4381-4390.
22. Mei L, Lai J, Roeske WR, Fraser CM, Venter JC and Yamamura HI (1989a) Pharmacological characterization of the M1 muscarinic receptors expressed in murine fibroblast B82 cells. J Pharmacol Exp Ther 248:661-670.
23. Mei L, Lai J, Yamamura HI and Roeske WR (1989b) The relationship between agonist states of the M1 muscarinic receptor and the hydrolysis of inositol lipids in transfected murine fibroblast cells (B82) expressing different receptor densities. J Pharmacol Exp Ther 251:90-97.
24. Melchiorre C, Angeli P, Lambrecht G, Mutschler E, Picchio MT and Wess J (1987) Antimuscarinic action of methoctramine: A new cardioselective M2 muscarinic receptor antagonist alone and in combination with atropine. Eur J Pharmacol 144:117-124.
25. Peralta EG, Ashkenazi A, Winslow JW, Ramachandran J and Capon DJ (1988) Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes. Nature (Lond) 334:434-437.
26. Peralta EG, Ashkenazi A, Winslow JW, Smith DH, Ramachandran J and Capon DJ (1987a) Distinct primary structures ligand-binding properties and tissue specific expression of four human muscarinic acetylcholine receptors. EMBO J 6:3923-3929.
27. Peralta EG, Winslow JW, Peterson GL, Smith DH, Ashkenazi A, Ramachandran J, Schimerlik MI and Capon DJ (1987b) Primary structure and biochemical properties of an M2 muscarinic receptor. Science 236:600-603.
28. Roeske WR and Yamamura HI (1980) Muscarinic cholinergic receptor regulation, in Psychopharmacology and Biochemistry of Neurotransmitter Receptors (Yamamura HI, Olsen RW and Usdin E, eds) pp 101-122, Elsevier North-Holland, New York, NY.
29. Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Arlich HA and Arnheim N (1985) Primer directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 230:1350-1354.
30. Sanger F, Nicklen S and Coulson AR (1977) DNA sequencing with chain terminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467.
31. Sharma VK, Colecraft MM, Rubin LR and Sheu S-S (1997) Does mammalian heart contain only the M2 muscarinic receptor subtype? Life Sci 13/14:1023-1029.
32. Spiker DG, Weiss AN, Chang SS, Reintsch JF and Biggs JT (1976) Tricyclic antide-pressant overdose: Clinical presentation and plasma level. Clin Pharmacol Ther 18:539-546.
33. 3H]AF-DX 116. Brain Res 446:155-158.
34. 3H] pirenzepine binding in the rat provide evidence for distinct M1 and M2 muscarinic receptor subtypes. Life Sci 32:3001-3011.
35. 3H]quinuclidinyl benzilate binding to rat cerebral cortical and cardiac muscarinic cholinergic sites. I: Characterization and regulation of agonist binding to putative muscarinic subtypes. J Pharmacol Exp Ther 237:411-418.
36. Wess J, Bonner TI, Dorje F and Brann MR (1990) Delineation of muscarinic receptor domains conferring selectivity of coupling to guanine nucleotide-binding proteins and second messengers. Mol Pharmacol 38:517-523.
37. Wess J, Liu J, Blin N, Yun J, Lerche C and Kostenis E (1997) Structural basis of receptor/G protein coupling selectivity as studied with muscarinic receptors as model systems. Life Sci 13/14:1007-1014.
38. Yamada S, Yamamura HI and Roeske WR (1980) Alterations in cardiac autonomic receptors following 6-hydroxydopamine treatment in rats. Mol Pharmacol 18:185-192.
39. βγ and α subunit of a receptor-activated G-protein. Proc Natl Acad Sci USA 93:2827-2831.