Lipid transfer protein I facilitated transfer of cyclosporine from low- to high-density lipoproteins is only partially dependent on its cholesteryl ester transfer activity

Journal of Pharmacology and Experimental Therapeutics

Volumn 284, Issue 2, 1998, Pages 599-605

  Wasan, Kishor M ^a   Ramaswamy, Manisha ^a   Wong, Wesley ^a   Pritchard, P Haydn ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL ESTER; CYCLOSPORIN; HIGH DENSITY LIPOPROTEIN; LIPID TRANSFER PROTEIN; LOW DENSITY LIPOPROTEIN; MONOCLONAL ANTIBODY; VERY LOW DENSITY LIPOPROTEIN;

AFFINITY CHROMATOGRAPHY; ARTICLE; CALCULATION; DIFFUSION; DRUG ABSORPTION; HUMAN; HYPERLIPIDEMIA; HYPOTHESIS; ISOTOPE LABELING; LIPID METABOLISM; LIPOPHILICITY; LIPOPROTEIN BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TRANSPORT; ULTRACENTRIFUGATION;

CARRIER PROTEINS; CHOLESTEROL ESTER TRANSFER PROTEINS; CHOLESTEROL ESTERS; CYCLOSPORINE; GLYCOPROTEINS; HUMANS; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; PROTEIN BINDING;

EID: 0031933386     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Albers JJ, Tollefson JH, Chen, C-H and Steinmetz A (1984) Isolation and characterization of human lipid transfer proteins. Arteriosclerosis 4:49-58.
2. Arnadottir M, Thysell H and Nilsson-Ehle P (1991) Lipoprotein levels and postheparin lipase activities in kidney transplant recipients: Ciclosporin-versus nonciclosporin-treated patients. Am J Kidney Dis 17:700-717.
3. Awni WM and Sawchuk RJ (1985) The pharmacokinetics of cyclosporine. II. Blood plasma binding and distribution. Drug Metab Disp 13:133-138.
4. Awani WM, Kasiske BL, Heim-Duthoy K and Rao KV (1989) Long-term cyclosporin pharmacokinetic changes in renal transplant recipients. Clin Pharmacol Ther 45:41-51.
5. Bolard J, Seigneuret M and Boudet G (1980) Interaction between phospholipid bilayer membranes and the polyene antibiotic amphotericin B. Lipid state and cholesterol content dependence. Biochim Biophys Acta 599:280-293.
6. Brunner LJ, Luke DR, Lautersztain J, et al. (1990) Single-dose cyclosporine pharmacokinetics in various biological fluids of patients receiving allogenic bone marrow transplantation. Ther Drug Monit 12:134-138.
7. Burstein M, Scholnick HR and Morfin R (1970) Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res 11:583-595.
8. de Groen PC, Aksamit AJ, Rakela J, Forbes GS and From RAF (1987) Central nervous system toxicity after liver transplantation. N Engl J Med 317:861-866.
9. de Groen PC (1988) Cyclosporin, low-density lipoprotein, and cholesterol. Mayo Clin proc 63:1012-1021.
10. De Kippel N, Sennesael J, Lamote J, Ebinger G and De Keyser J (1992) Cyclosporin leukoencephalopathy induced by intravenous lipid solution. Lancet 339:1114-1115.
11. Gardier AM, Mathe D, Guedeney X, Barre J, Benvenutti C, Navarro N, Vernillet L, Loisance D, Cachera JP, Jacotot B and Tillement JP (1993) Effects of plasma lipid levels on blood distribution and pharmacokinetics of Cyclosporin A. Ther Drug Monit 15:274-280.
12. Grundy SM (1990) Cholesterol transport, in Cholesterol and Atherosclerosis: Diagnosis and Treatment (Gabello WJ ed) pp 1.6-1.23, JP, Lippincott Co. New York.
13. Havel RJ, Eder HA and Bragdon JH (1955) The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34:1345-1353.
14. Hesler CB, Tall AR, Swenson TL, Weech PK, Marcel YL and Milne RW (1988) Monoclonal antibodies to the Mr 74,000 cholesteryl ester transfer protein neutralize all of the cholesteryl ester and triglyceride transfer activities in human plasma. J Biol Chem 263:5020-5023.
15. Hughes TA, Gaber AO and Montgomery CE (1991) Plasma distribution of cyclosporine within lipoproteins and "in vitro" transfer between very-low-density lipoproteins, low-density lipoproteins, and high-density lipoproteins. Ther Drug Monit 13:289-295.
16. Jarngin AS, Kohr W and Fielding C (1987) Isolation and specificity of a Mr 74,000 cholesteryl ester transfer protein from human plasma. Proc Natl Acad Sci USA 84:1854-1860.
17. Keown PA (1990) Emerging indications for the use of Cyclosporin in organ transplantation and autoimmunity. Drugs 40:315-325.
18. Lemaire M, Pardridge WM and Chaudhuri G (1988) Influence of blood components on the tissue uptake indices of cyclosporin in rats. J Pharmacol Exp Ther 244:740-743.
19. Macoviak JA, Oyer PE, Stinson EB, Jamieson SW, Baldwin JC and Shumway NE (1985) Four-year experience with cyclosporine for heart and heart-lung transplantation. Transplant Proc 17(suppl. 2):97-101.
20. Morton RE and Zilversmit DB (1982) Purification and characterization of lipid transfer protein(s) from human lipoprotein-deficient plasma. J Lipid Res 23:1058-1067.
21. Morton RE and Zilversmit DB (1983) Inter-relationships of lipid transferred by the lipid transfer protein isolated from human lipoprotein-deficient plasma. J Biol Chem 258:11751-11756.
22. Morton RE (1990) Interaction of lipid transfer protein with plasma lipoproteins and cell membranes. Experimentia 46:552-560.
23. Moulin P, Appel GB, Ginsberg HN and Tall AR (1992) Increased concentration of plasma cholesteryl ester transfer protein in nephrotic syndrome: role in dyslipidemia. J Lipid Res 33:1817-1822.
24. Mraz W, Zink RA, Graf A, Preis D, Illner WD, Land W, Siebert W and Zottlein H (1983) Distribution and transfer of cyclosporine among the various human lipoprotein classes. Transplant Proc 51:2426-2429.
25. Nemunaitis J, Deeg HJ and Yee GC (1986) High cyclosporin levels after bone marrow transplantation associated with hypertriglyceridemia. Lancet 1:744-745.
26. Pardridge WM (1979) Carrier-mediated transport of thyroid hormones through the rat blood-brain barrier. Primary role of albumin-bound hormone. J Clin Invest 64:145-154.
27. Pattnaik NM and Zilversmit DB (1979) Interaction of cholesteryl ester exchange protein with human plasma lipoproteins and phospholipid vesicles. J Biol Chem 254:2782-2786.
28. Rajaram OV, White GH and Barter PJ (1980) Partial purification and characterization of a triacylglycerol-transfer protein from rabbit serum. Biochim Biophys Acta 617:383-390.
29. Ramaswamy M, Zhang X, Burt HM and Wasan KM (1997) The human plasma distribution of free paclitaxel and paclitaxel associated with diblock copolymers. J Pharm Sci 86:460-464.
30. Rifai N, Chao FF, Pham Q, Thiessen J and Soldin SJ (1996) The role of lipoproteins in the transport and uptake of cyclosporine and dihydro-tacrolimus in HepG2 and JURKAT cell lines. Clin Biochem 29:149-155.
31. Sgoutas D, MacMahon W, Love A and Jerkunica I (1986) Interaction of cyclosporine A with human lipoproteins. J Pharm Pharmacol 38:583-588.
32. Tall AR, Abreau E and Shuman J (1983) Separation of a plasma phospholipid transfer protein from cholesterol ester/phospholipid exchange protein. J Biol Chem 258:2174-2178.
33. Wasan KM, Brazeau GA, Keyhani A, Hayman AC and Lopez-Berestein G (1993) Role of liposome composition and temperature on the distribution of amphotericin B in serum lipoproteins. Antimicrob Agents Chemother 37:246-250.
34. Wasan KM, Morton RE, Rosenblum MG and Lopez-Berestein G (1994) Decreased toxicity of liposomal amphotericin B due to association of amphotericin B with high density lipoproteins: Role of lipid transfer protein. J Pharm Sci 83:1006-1010.
35. Wasan KM and Lopez-Berestein G (1995) Targeted liposomes in fungi: Modifying the therapeutic index of amphotericin B by its incorporation into negatively charged liposomes. J Liposome Res 5:883-903.
36. Wasan KM (1996) Modifications in plasma lipoprotein concentration and lipid composition regulate the biological activity of hydrophobic drugs. J Pharmacol Toxicol Methods 36:1-11.
37. Wasan KM, Pritchard PH, Ramaswamy M, Wong W, Donnachie EM and Brunner LJ (1997) Differences in lipoprotein lipid concentration and composition modify the plasma distribution of cyclosporine. Pharm Res, 14:1613-1620.
38. Wong RL, Winslow CM and Cooper KD (1993) The mechanisms of action of cyclosporin A in the treatment of psoriasis, Immunol Today 14:69-74.