Differential expression of matrix metalloproteinases in activated c-ras(Ha)-transfected immortalized human keratinocytes

British Journal of Cancer

Volumn 77, Issue 5, 1998, Pages 724-730

  Meade Tollin, L C ^a,c   Boukamp, P ^b   Fusenig, N E ^b   Bowen, C P R ^a   Tsang, T C ^a   Bowden, G T ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Gelatinase; HaCaT ras; Human; Keratinocyte; Malignant progression; Matrilysin; Matrix metalloproteinase

Indexed keywords

EDETIC ACID; GELATINASE A; GELATINASE B; MATRILYSIN; MATRIX METALLOPROTEINASE; MESSENGER RNA; PROTEINASE;

ANIMAL EXPERIMENT; ARTICLE; CELL IMMORTALIZATION; CONNECTIVE TISSUE; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; KERATINOCYTE; NONHUMAN; NUDE MOUSE; ONCOGENE C H RAS; PHENOTYPE; PRIORITY JOURNAL; SKIN CARCINOGENESIS; SQUAMOUS CELL CARCINOMA;

EID: 0031932803     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.119     Document Type: Article

References (51)

1. Aviv H and Leder P (1972) Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc Natl Acad Sci USA 69: 1408-1412
2. Basset P, Bellocq JP, Wolf C, Stoll I, Hutin P, Limacher JM, Podhajcer OL, Chenard MP, Rio MC and Chambon P (1990) A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. Nature 348: 699-704
3. Bernhard EJ, Hagner B, Wong C, Lubenski I and Muschel RJ (1995) The effect of E1A transfection on MMP-9 expression and metastatic potential. Int J Cancer 60: 718-724
4. Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A and Engler JA (1991) Matrix metalloproteinases: a review. (Review). Crit Rev Oral Biol Med 4: 197-250
5. Borchers AH, Powell MB, Fusenig NE and Bowden GT (1994) Paracrine factor and cell-cell contact-mediated induction of protease and c-ets: gene expression in malignant keratinocyte/dermal fibroblast cocultures. Exp Cell Res 213: 143-147
6. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A and Fusenig NE (1988) Normal keratinization in a spontaneously immortalized ancuploid human keratinocyte cell line. J Cell Biol 106: 761-771
7. Boukamp P, Stanbridge E, Foo D, Cerutti P and Fusenig NE (1990) c-Ha-ras oncogene expression in immortalized human keratinocytes ( HaCaT) alters growth potential in vivo but lacks correlation with malignancy. Cancer Res 50: 2840-2847
8. Boukamp P, Breitkreutz D, Hulsen A, Tomakidi P and Fusenig NE (1993) In vitro transformation and tumor progression: a multistep model lor skin carcinogenesis. In The Keratinocyte Handbook, Leigh I, Lane B, and Watt F (eds), pp. 485-499. Cambridge University Press: Cambridge, UK
9. 1 72.000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines. Cancer Res 50: 6184-6191
10. Chen L, Narayanan R, Hibbs M, Benn P, Clawson M, Lu G, Rhim J, Greenberg B and Mendelsohn J (1993) Altered epidermal growth factor signal transduction in activated Ha-ras-transformed human keratinocytes. Biochem Biophy Res Comm 193: 167-174
11. Chomczynski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-169
12. Collier IE, Wilhelm SM, Eisen AZ, Marmar BL, Grant GA, Seitzer JL, Kronberger A, He C, Bauer EA and Goldberg GI (1988) H-ras-oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement-membrane collagen. J Biol Chem 263: 6579-6587
13. Delaney A and Brinckerhoff C (1992) Post-transcriptional regulation of collagenase and stromelysin gene expression by epidermal growth factor and dexamethasone in cultured human fibroblasts. J Cell Biochem 50: 400-410
14. Fusenig NE, Boukamp P, Breitkreutz D and Hulsen A (1991) Altered regulation of growth and differentiation at different stages of transformation of human skin keratinocytes. In Neoplastic Transformation in Human Cell Culture, Rhim JS and Dritschillo A (eds), pp. 235-250. Humana Press: Totowa, NJ
15. Fusenig NE and Boukamp P (1994) Carcinogenesis studies of human cells: Reliable in vitro models. In Celt Culture in Pharmaceutical Research, Graf H (ed,), pp. 79-102. Springer: Heidelberg
16. Game SM, Huelsen A, Patel V, Donely M, Yeudal W, Stone AF, Fusenig NE and Prime SS (1992) Progressive abrogation of TGF-β1 and EGF growth control is associated with tumour progression in ras-transfected human keratinocytes. Int J Cancer 52: 461-470
17. Gum R, Lengyel E, Juarez J, Chen JH, Sato H, Seikii M and Boyd D (1996) Stimulation of 92-kDa gelatinase b promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences. J Biol Chem 271: 10672-10680
18. Henrard D, Thornley A, Brown ML and Rheinwald JG (1990) Specific effects of ras oncogene expression on the growth and histogenesis of human epidermal keratinocytes. Oncogene 5: 475-481
19. Hewitt RE, Leach IH, Powe DG, Clark IM, Cawston T and Turner DR (1991) Distribution of collagenase and tissue inhibitor of metalloproteinases (TIMP) in colorectal tumors. Int J Cancer 49: 666-672
20. Holladay K, Fujiki H, Bowden GT (1992) Okadaic acid induces the expression of both early and secondary response genes in mouse keratinocytes. Mol Carcinogen 5: 16-24
21. Hurlin P, Kaur P, Smith PP, Periz-Reyes N, Blanton R and McDougall JK (1991) Progression of human papillomavirus type 18-immortalized human keratinocytes to a malignant phenotype. Proc Natl Acad Sci USA 88: 570-574
22. 1. Cell Growth Diff 8: 243-250
23. Juarez J, Clayman G, Nakajima M, Tanabe K, Saya H, Nicolson G and Boyd D (1993) Role and regulation of expression of 92-kDa type-IV collagenase (MMP-9) in 2 invasive squamous-cell carcinoma cell lines of the oral cavity. Int J Cancer 55: 10-18
24. Kusukawa J, Susaguri Y, Shinia I, Kameyama T and Morimutsu M (1993) Expression of matrix metalloproteinase-2 related to lymph node metastasis of oral squamous cell carcinoma. A clinicopathologic study. Am J Clin Pathol 99: 18-23
25. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685
26. Lee M, Yang J, Salehi Z, Arnstein P, Chen L, Jay G and Rhim J (1993) Neoplastic transformation of a human keratinocyte cell line by the v-fos oncogene. Oncogene 8: 387-393
27. Marcel MM, De Baetseller P and Van Roy HM (1991) Cellular activities implicated in invasion and metastasis. In Mechanisms of Invasion and Metastasis. Mareel MM, De Baetselier P and Van Roy FM (eds). pp. 73-219. CRC Press: Boca Raton, FL
28. Matrisian LM, Glacihenhaus N, Gesnel M and Breathnach R (1985) Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts. EMHO J 4: 1435-1440
29. McDonnell S, Navre M, Coffey RJ Jr and Matrisian LM (1991) Expression and localization of the matrix metalloproteinase PUMP-1 (MMP-7) in human gastric and colon carcinomas. Mol Carcinogen 4: 527-533
30. Meade-Tollin L, Bowen CP, Fusenig N and Bowden GT (1992) Matrix metalloproteinase mRNA expression in C-Ha-ras transfected human keratinocytes (Abstract). Proc Am Assoc Cancer Res 33: 68
31. Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J and Breathnach R (1988) The collagenase gene family in humans consists of at least four members. Biochem J 253: 187-192
32. Muller DB, Breathnach R, Engelmann A, Millon R, Bronner G, Flesch H and Dumont P, Eber M, Abecassis J (1991) Expression of collagenase-related metalloproteinase genes in human lung or head and neck tumors. Int J Cancer 481: 550-556
33. Pajouh MS, Nagle RB, Breathnach R, Finch JS, Brawer MK and Bowden GT (1991) Expression of metalloproteinase genes in human prostate cancer. J Cancer Res Clin Oncol 117: 1-7
34. Peltz SW, Brewer G, Bernstein P, Hart PA and Ross J (1991) Regulation of mRNA turnover in eukaryotic cells. Crit Rev Eukaryotic Gene Expression 1: 99-126
35. Pendás AM, Knäuper V, Puente XS, Llano E, Mattei M, Apte S, Murphy G and Lopez-Otin C (1997) Identification of characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution. J Biol Chem 272: 4281-4286
36. Petersen MJ, Woodley D, Stricklin G and O'Keefe E (1989) Constitutive production of procollagenase and tissue inhibitor of metalloproteinases bv human keratinocytes in culture. J Invest Dermatol 92: 156-159
37. Polette M, Clavel C, Muller D, Abecassis J, Binninger I and Birembaut P (1991) Detection of mRNAs encoding collagenase 1 and stromelysin 2 in carcinomas of the head and neck by in situ hybridization. Invasion Metastasis 11: 76-83
38. Powell WC, Knox JD, Navre M, Grogan TM, Kittelson J, Nagle RB and Bowden GT (1993) Expression of the metalloproteinase matrilysin in DU-145 cells increases their invasive potential in severe combined immunodeficient mice. Cancer Res 53: 417-422
39. Pyke C, Ralfkiaer EH, Huhtala P, Hurskainen T, Dano K and Tryggvason K (1992) Localisation of messenger RNA for Mr 72.000 and 92.000 type IV collagenases in human skin cancers by in situ hybridisation. Cancer Res 52: 1336-1341
40. Quantin B, Murphy G and Breathnach R (1989) Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members. Biochemisrty 28: 5327-5334
41. Ray JM and Stetler-Stevenson WG (1994) The role of matrix metalloproteases and their inhibitors in tumor invasion, metastasis, and angiogenesis. Eur Resp J 7: 2062-2072
42. Rhim JS, Yoo JH, Park JH, Thraves P, Salehi Z and Dritschillo A (1990) Evidence fur the multi-step nature of in vitro human epithelial cell carcinogenesis. Cancer Res 50: 5653s-5657s
43. Roop DR, Lowy DR, Tambourin PE, Strickland J, Harper JR, Balaschak M, Spangler BH and Yuspa SH (1986) An activated harvey ras oncogene produces benign tumors on mouse epidermal tissue. Nature 323: 822-824
44. Sarret Y, Woodley D, Goldberg G, Kronberger A and Wynn KC (1992) Constitutive synthesis of a 92-kDa Type IV collagenase is enhanced by Type 1 collagen and decreased by Type IV collagen matrices. J Invest Dermatol 99: 836-841
45. Shapiro S, Doyle G, Ley T, Parks W and Welgus H (1993) Molecular mechanisms regulating the production of collagenase and TIMP in U937 cells: Evidence for involvement of delayed transcriptional activation and enhanced mRNA stability. Biochemistry 32: 4286-4242
46. Shima I, Sasaguri Y, Kusukawa J, Nakano R, Yamana H, Fujita H, Kakegawa T and Morimatsu M (1993) Production of matrix metalloproteinase 9 (92-kDa gelatinase) by human oesophageal squamous cell carcinoma in response to epidermal growth factor. Br J Cancer 67: 721-727
47. Smith, JA (1994) Quantitation of proteins. Ausubel FB, Brent R, Kingston RL, Moore DD, Smith JA, Seidman JG and Struhl K (eds), 10.1.1-10.1.3. Greene Publishing Associates and Wiley-Interscience. New York.
48. Stetler-Stevenson W (1990) Type IV collagenases in tumor invasion and metastasis. Cancer Metast Rev 9: 289-303
49. Thraves P, Salehi Z, Dritschillo A and Rhim JS (1990) Neoplastic transformation of immortalized human epidermal keratinocytes by ionizing radiation. Proc Natl Acad Sci USA 87: 1174-1177
50. Tryggvason K, Hoyhtya M and Pyke C (1993) Type IV collagenases in invasive tumors. Breast Cancer Res Treat 24: 209-218
51. Wilhelm SM, Collier IE, Marmer BL, Eisen AZ, Grant GA and Goldberg GI (1989) SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages. J Biol Chem 264: 17213-17221