Growth suppression mediated by transfection of wild-type hMLH1 in human cancer cells expressing endogenous truncated hMLH1 protein

International Journal of Oncology

Volumn 12, Issue 3, 1998, Pages 609-615

  Shin, Ki Hyuk ^a   Han, Hye Jung ^a   Park, Jae Gahb ^a  

^a Seoul National University   (South Korea)

Author keywords

Antiproliferative activity; hMLH1; Human cancer cells; In vitro tumorigenicity; Mismatch repair

Indexed keywords

COMPLEMENTARY DNA; DNA; MESSENGER RNA; MUTANT PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; BASE MISPAIRING; CANCER CELL CULTURE; CANCER GROWTH; CELL PROLIFERATION; COLONY FORMING UNIT; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA SYNTHESIS; DNA TRANSFECTION; GENE EXPRESSION; HUMAN; HUMAN CELL; NONSENSE MUTATION; PRIORITY JOURNAL; STOMACH CARCINOMA;

EID: 0031932659     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.12.3.609     Document Type: Article

References (32)

1. Lindblom A, Tannergard P, Nordenskjold W and Nordenskjold M: Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer. Nat Genet 5: 279-282, 1993.
2. Nystrom-Lahti M, Parsons R, Sistonen P, Pylkkanen L, Aaltonen LA, Leach FS, Hamilton SR, Watson P, Bronson E, Fusaro R, Cavalieri J, Lynch J, Lanspa S, Smyrk T, Lynch P, Drouhard T, Kinzler KW, Vogelstein B, Lynch HT, de la Chapelle A and Peltomaki P: Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary non-polyposis colorectal cancer families evaluable by linkage. Am J Hum Genet 55: 659-665, 1994.
3. Papadopoulos N, Nicolaides NC, Wei YF, Ruben SM, Carter KC, Rosen CA, Haseltine WA, Fleischman RD, Fraser CM, Adams MD, Venter JC, Hamilton SR, Peterson GM, Watson P, Lynch HT, Peltomaki P, Mecklin JP, de la Chapelle A, Kinzler KW and Vogelstein B: Mutation of a mutL homologue in hereditary colon cancer. Science 263: 1625-1629, 1994.
4. Umar A, Boyer JC, Thomasm DC, Nguyen DC, Risinger JI, Boyd J, Ionov Y, Perucho M and Kunkel TA: Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J Biol Chem 269: 14367-14370, 1994.
5. Risinger JI, Umar A, Boyer JC, Evans AC, Berchuck A, Kunkel TA and Barrett JC: Microsatellite instability in gynecological sarcomas and hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity. Cancer Res 55: 5664-5669, 1995.
6. Liu B, Nicolaides NC, Markowitz S, Willson JKV, Parsons RE, Jen J, Papadopoulos N, Peltomaki P, de la Chapelle A, Hamilton SR, Kinzler KW, Jiricny J and Vogelstein B: Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat Genet 9: 48-55, 1995.
7. + tumor cells. Cell 74: 1227-1236, 1993.
8. Thibodeau SN, Bren G and Schaid D: Microsatellite instability in cancer of the proximal colon. Science 260: 816-819, 1993.
9. Han HJ, Yanagisawa A, Kato Y, Park JG and Nakamura Y: Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Res 53: 5087-5089, 1993.
10. Rhyu MG, Park WS and Meltzer SJ: Microsatellite instability occurs frequently in human gastric carcinoma. Oncogene 9: 29-32, 1994.
11. n repeats and tumor suppressor genes in human gastric cancer. Cancer Res 54: 41-44, 1994.
12. Peltomaki P, Lothe RA, Aaltonen LA, Pylkkanen L, Nystronlahti M, Seruca R, David L, Holm R, Ryberg D, Hausen A, Broggar A, Borresen A-L and de la Chapelle A: Microsatellite instability is associated with tumor that characterize the hereditary non-polyposis colorectal carcinoma syndrome. Cancer Res 53: 5853-5855, 1993.
13. Polascik YJ, Cairns P, Epstein JI, Fuzesi L, Ro JY, Marshall FF, Sidransky D and Schoenberg M: Distal nephron renal tumor: Microsatellite alleotype. Cancer Res 56: 1892-1895, 1996.
14. Modrich P and Lahue R: Mismatch repair in replication fidelity, genetic recombination and cancer biology. Annu Rev Biochem (In press).
15. Kolodner RD: Mismatch repair: mechanisms and relationship to cancer susceptibility. Trends Biochem Sci 20: 397-401, 1995.
16. Koi M, Umar A, Chauhan DP, Cheian SP, Careghers JM, Kunkel TA and Boland CR: Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res 54: 4308-4312, 1994.
17. Barbacid M: Ras gene. Annu Rev Biochem 56: 779-827, 1987.
18. Bishop JM: The molecular genetics of cancer. Science 235: 305-311, 1987.
19. Alitalo K, Koskinen P, Makela TP, Saksela K, Sostenen L and Winqvist R: myc oncogenes activation and amplification. Biochem Biophys Acta: 907: 1-32, 1987.
20. Sanger R: Tumor suppressor genes: the puzzle and the promise. Science 246: 1406-1412, 1989.
21. Hollstein M, Sidransky D, Vogelstein B and Harris CC: p53 mutations in human cancer. Science 253: 49-53, 1991.
22. Park J-G, Frucht H, LaRocca RV, Bliss DP Jr, Kurita Y, Chen T-R, Henslee JG, Trepel JB, Jensen RT, Johnson BE, Bang Y-J, Kim J-B and Gazda AF: Characteristics of cell lines established human gastric carcinoma. Cancer Res 50: 2773-2780, 1990.
23. Park K, Kim S-J, Bang Y-J, Park J-G, Kim NK, Roberts AB and Sporn MB: Genetic changes in the transforming growth factor β (TGF-β) type II receptor gene in human gastric cancer cells: Correlation with sensitivity to growth inhibition by TGF-β. Proc Natl Acad Sci USA 91: 8772-8776, 1994.
24. Myeroff LL, Parsons R, Kim S-J, Hedrick L, Cho KR, Orth K, Mathis M, Kinzler KW, Lutterbaugh J, Park K, Bang Y-J, Lee HY, Park J-G, Lynch HT, Roberts AB, Vogelstein B.and Markowitz SD: A transforming growth factor β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res 55: 5545-5547, 1995.
25. Shin K-H, Min B-M, Cherrick HM and Park N-H: Combined effects of human papillomavirus-18 and N-methyl-N′-nitro-N-nitrosoguanidine on the transformation of normal oral keratinocytes. Mol Carcinog 9: 76-86, 1994.
26. Lassar AB, Davis RL, Wright WE, Kadesch T, Murre C, Voronova A, Baltimore D and Weintraub H: Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell 66: 305-315, 1991.
27. Boyer JC, Umar A, Risinger JI, Lipford JR, Kane M, Yin S, Barrett JC, Kolodner RD and Kunkel TA: Microsatellite instability, mismatch repair deficiency and genetic defects in human cancer cell lines. Cancer Res 55: 6063-6070, 1995.
28. Putman DL, Park DK, Rhim JS, Stueuer AF and Ting RC: Correlation of cellular aggregation of transformed cells with their growth in soft agar and tumorigenic potential. Proc Soc Exp Biol Med 155: 487-494, 1977.
29. Rhim JS, Koh KS and Essex M: Characterization of clones of tumorigenic feline cells transformed by a chemical carcinogen. Int J Cancer 28: 51-57, 1981.
30. Vousden KH, Doninger J, DiPaolo JA and Lowy DR: The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene. Oncogene Res 3: 167-175, 1988.
31. Traut KA, Kachevsky V and Wolff JS: A rapid in vitro assay for carcinogenicity of chemical substances in mammalian cells utilizing an attachment-independence endpoint. Int J Cancer 23: 193-196, 1979.
32. Hawn MT, Umar A, Carethers JM, Marra G, Kunkel TA, Boland CR and Koi M: Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res 55: 3721-3725, 1995.