Evidence for a strychnine-sensitive mechanism and glycine receptors involved in the control of urethral sphincter activity during micturition in the cat

Experimental Brain Research

Volumn 119, Issue 3, 1998, Pages 297-306

  Shefchyk, S J ^a   Espey, M J ^a   Carr, P ^a,b   Nance, D ^a   Sawchuk, M ^a   Buss, R ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b WRIGHT STATE UNIVERSITY   (United States)

Author keywords

Bladder sphincter dyssynergia; Cat; Interneurons; Micturition; Spinal inhibition

Indexed keywords

CHOLINE ACETYLTRANSFERASE; GEPHYRIN; GLYCINE; GLYCINE RECEPTOR; MONOCLONAL ANTIBODY; PORPHYRIN; STRUCTURAL PROTEIN; STRYCHNINE;

ANIMAL EXPERIMENT; ANUS SPHINCTER; ARTICLE; BLADDER CONTRACTION; BLADDER DISTENSION; BLADDER SPHINCTER; CAT; CONTROLLED STUDY; ELECTROSTIMULATION; FEMALE; MALE; MICTURITION; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; REFLEX;

ANIMALS; CARRIER PROTEINS; CATS; DECEREBRATE STATE; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; FEMALE; GLYCINE AGENTS; MALE; MEMBRANE PROTEINS; MOTOR NEURONS; NEURAL INHIBITION; RECEPTORS, GLYCINE; SPINAL CORD; STRYCHNINE; URETHRA; URINARY BLADDER; URINATION;

EID: 0031932115     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002210050345     Document Type: Article

References (56)

1. Alvarez FJ, Dewey DE, Harrington D, Fyffe REW (1997) Cell-type specific organization of glycine receptor clusters in the mammalian spinal cord. J Comp Neurol 379:150-170
2. Angel MJ, Fyda D, McCrea DA, Shefehyk SJ (1994) Primary afferent depolarization of cat pudendal afferents during micturition and segmental afferent stimulation. J Physiol (Lond) 479: 451-461
3. Beattie MS, Li Qun, Leedy MG, Bresnahan J (1990) Motoneurons innervating the external anal and urethral sphincter of the female cat have different patterns of dendritic arborization. Neurosci Lett 111:69-74
4. Béchade C, Sur C, Triller (1994) A The inhibitory neuronal glycine receptor. Bioessays 16:735-744
5. Betz H, Becker C-M (1988) The mammalian glycine receptor: biology and structure of a neuronal chloride channel protein. Neurochem Int 13:137-146
6. Blaivas JG, Sinha HP, Zayed AAH, Labib KB (1981) Detrusorexternal sphincter dyssynergia: a detailed EMG study. J Urol 125:545-548
7. A-receptors at GABAergic synaptic contracts demonstrated by triple immunofluorescence staining. Brain Res 642: 59-69
8. Bracci E, Ballerini L, Nistri N (1996) Spontaneous rhythmic bursts induced by pharmacological block of inhibition in lumbar motoneurons of the neonatal rat spinal cord. J Neurophysiol 75:640-647
9. Carr PA, Noga BR, Nance DM, Jordan LM (1994) Intracellular labeling of cat spinal neurons using a tetramethylrhodamine-dextran amine conjugate. Brain Res Bull 34:447-451
10. Cowley KC, Schmidt BJ (1995) Effects of inhibitory amino acid antagonists on reciprocal inhibitory interactions during rhythmic motor activity in the in vitro neonatal rat spinal cord. J Neurophysiol 74:1109-1117
11. Cowley KC, Schmidt BJ (1997) Regional distribution of the locomotor pattern-generating network in the neonatal rat spinal cord. J Neurophysiol 77:247-259
12. Cullheim S, Kellerth J-O (1981) Two kinds of recurrent inhibition of cat spinal Ia-motoneurones as differentiated pharmacologically. J Physiol (Lond) 312:209-224
13. Dubrovsky B, Filipini D (1989) Neurobiological aspects of the pelvic floor muscles involved in defecation. Neurosci Biobehav Rev 14:157-168
14. Espey MJ, Buss R, Nance DM, Sawchuk M, Carr P, Shefchyk S (1996) Anatomical and pharmacological evidence for glycinergic control of urethral sphincter motoneurons in cat. Soc Neurosci Abstr 22:723.20
15. Evans MH, McPherson A (1959) The effects of distension of the bladder on somatic reflexes in the cat. J Physiol (Lond) 146:438-458
16. Evans MH, McPherson A (1960) The effects of electrical stimulation of visceral afferent nerve fibres on monosynaptic and polysynaptic reflex responses. J Physiol (Lond) 150:105-113
17. Fedirchuk B, Shefchyk SJ (1991) Effects of electrical stimulation of the thoracic spinal cord on bladder and external urethral sphincter activity in the decerebrate cat. Exp Brain Res 84:635-642
18. Fedirchuk B, Shefchyk SJ (1993) Membrane potential changes in sphincter motoneurons during micturition in the decerebrate cat. J Neurosci 13:3090-3094
19. Fedirchuk B, Hochman S, Shefchyk SJ (1992) An intracellular study of perineal and hindlimb afferent inputs onto pudendal motoneurons in the decerebrate cat. Exp Brain Res 89:511-516
20. Fedirchuk B, Downie JW, Shefchyk SJ (1994) Reduction of perineal evoked excitatory postsynaptic potentials in cat lumbar and sacral motoneurons during micturition. J Neurosci 14:6153-6159
21. Fyffe REW (1991) Glycine-like immunoreactivity in synaptic boutons of identified inhibitory interneurons in the mammalian spinal cord. Brain Res 547:175-179
22. Garry RC, Roberts TDM, Todd JK (1959) Reflexes involving the external urethral sphincter in the cat. J Physiol (Lond) 149: 653-665
23. Glazer EJ, Basbaum II (1980) Leucine enkephalin: localization in and axoplasmic transport by sacral parasympathetic preganglionic neurons. Science 208:1479-1481
24. Holstege JC, Bongers CMH (1991) A glycinergic projection from the ventromedial lower brain stem to spinal motoneurons: an ultrastructural double labeling study in rat. Brain Res 566:308-315
25. Jankowska E, Padel Y, Zarzecki P (1978) Crossed disynaptic inhibition of sacral motoneurones. J Physiol (Lond) 285:425-444
26. Jordan CL, Breedlove SM, Arnold AP (1982) Sexual dimorphism and the influence of neonatal androgen in the dorsolateral motor nucleus of the rat lumbar spinal cord. Brain Res 249:309-314
27. Kirsch J, Betz H (1993) Widespread expression of gephyrin. a putative glycine receptor-tubulin linker protein, in rat brain. Brain Res 621:301-310
28. Kirsch J, Wolters I, Triller A, Betz H (1993) Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons. Nature 366:745-748
29. Kremer E, Lev-Tov A (1997) Localization of the spinal network associated with generation of hindlimb locomotion in the neonatal rat and organization of its transverse coupling system. J Neurophysiol 77:1155-1170
30. Mackel R (1979) Segmental and descending control of the external urethral and anal sphincter in the cat. J Physiol (Lond) 294:105-122
31. Maggi, CA, Furio M, Santicioli P, Conte B, Meli A (1987) Spinal and supraspinal componenets of GABAergic inhibiton of the micturition reflex in rats. J Pharmacol Exp Ther 240:998-1005
32. Magora F, Shazar N, Drenger B (1989) Urodynamic studies after intrathecal administration of baclofen and morphine in dogs. J Urol 141:143-147
33. Martin WD, Fletcher TF, Bradley WE (1974) Innervation of feline perineal musculature. Anat Rec 180:15-30
34. Nanninga JB, Frost F, Penn R (1989) Effect of intrathecal baclofen on bladder and sphincter function. J Urol 142:101-105
35. Ornung G, Shupliakov O, Ottersen OP, Storm-Mathisen J, Cullheim S (1994) Immunohistochemical evidence for coexistence of glycine and GABA in nerve terminals on cat spinal motoneurones: an ultrastructural study. Neuroreport 5(8):889-892
36. Pearson JC, Alvarez FJ, Sedivec MJ, Torbeck L, Dewey DE, Fyffe REW (1995) Immunohistochemical analysis of the distribution of glycine receptors on dorsal spinocerebellar tract neurons in the cat. Soc Neurosci Abstr 21:380
37. Pol AN van den, Gores T (1988) Glycine and glycine receptor immunoreactivity in brain and spinal cord. J Neurosci 8:472-192
38. Pratt CA, Jordan LM (1987) Ia inhibitory interneurons and renshaw cells as contributors to the spinal mechanisms of fictive locomotion. J Neurophysiol 57:56-71
39. Ramírez-León V, Ulfhake B (1993) GABA-like immunoreactive innervation and dendro-dendritic contacts in the ventroluteral dendritic bundle in the cat S1 spinal cord segment: an electron microscopic study. Exp Brain Res 97:1-12
40. Rampai G, Mignard P (1975) Organization of the nervous control of urethral sphincter. Pflugers Arch 353:21-31
41. Rastad J, Gad P, Jankowska E, McCrea D, Westman J (1990) Light microscopical study of dendrites and perikarya of interneurones mediating Ia reciprocal inhibition of cat lumbar alpha-motoneurones. Anat Embryol 181:381-388
42. Sackman JE, Sims MH (1990) Electromyographic evaluation of the external urethral sphincter during cystometry in male cats. Am J Vet Res 51:1237-1241
43. Sasaki M (1994) Morphological analysis of external urethral and external anal sphincter motoneurones of cat. J Comp Neurol 349:269-287
44. Sethi RJ, Bauer SB, Dyro FM, Kramp C (1989) Modulation of the bulbocavernosus reflex during voiding: loss of inhibition in upper motor neuron lesions. Muscle Nerve 12:892-897
45. Shefchyk SJ (1997) Modulation of excitatory perineal reflexes and sacral striated sphincter motoneurons during micturition in the cat. In: Rudomin P, Romo R, Mendell L (eds) Presynaptic inhibition and neural control mechanisms. Oxford University Press, New York, pp 398-406
46. Shimoda N, Takakusaki K, Nishizawa O, Tsuchida S, Mori S (1992) The changes in the activity of pudendal motoneurons in relation to reflex micturition evoked in decerebrate cats. Neurosci Lett 135:175-178
47. Sivilotti L, Nistri A (1991) GABA receptor mechanisms in the central nervous system. Prog Neurobiol 36:35-92
48. Steers WD, Meythaler JM, Haworth C, Herrell D, Park TS (1992) Effects of acute bolus and chronic continuous intrathecal baclofen on genitourinary dysfunction due to spinal cord pathology. J Urol 148:1849-1855
49. Thor KB, Hisamitsu T, Roppolo JR, Tuttlc P, Nagel J, Croat WC de (1989a) Selective inhibitory effects of ethylkctocyclazocine on reflex pathways to the external urethral sphincter of the cat. J Pharmacol Exp Ther 248:1018-1025
50. Thor KB, Morgan C, Nadelhaft I, Houston M, Groat WC de (1989b) Organization of afferent and efferent pathways in the pudendal nerve of the female cat. J Comp Neurol 288:263-279
51. Todd AJ, Watt C, Spike RC, Sieghar W (1996) Colocalization of GABA, glycine and their receptors at synapses in the rat spinal cord. J Neurosci 16:974-982
52. Triller A, Cluzeaud F, Pfeiffer F, Betz H, Korn H (1985) Distrihution of glycine receptors at central synapses: an immunoelectron microscopy study. J Cell Biol 101:683-688
53. Triller A, Cluzeaud F, Korn H (1987) γ-Aminobutyric acid-containing synapses can be apposed to glycine receptors at central synapses. J Cell Biol 104:947-956
54. Ueyama T, Mizuno N, Nomura S, Konishi A, Itoh K, Arakawa H (1984) Central distribution of afferent and efferent components of the pudendal nerve in cat. J Comp Neurol 222:38-46
55. Vaines K, Brandtzaeg P (1985) Retardation of immunofluorescence fading during microscopy. J Histochem Cytochem 33: 755-761
56. 3H] strychnine. J Neurosci 1:532-547