Age-related changes in serum undercarboxylated osteocalcin and its relationships with bone density, bone quality, and hip fracture

Calcified Tissue International

Volumn 62, Issue 4, 1998, Pages 286-289

  Liu, G ^a   Peacock, M ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University of Hospital   (United States)

Author keywords

Bone density; Hip fracture; Ultrasound transmission velocity; Undercarboxylated osteocalcin; Vitamin K

Indexed keywords

25 HYDROXYVITAMIN D; BIOCHEMICAL MARKER; CALCIUM; OSTEOCALCIN; VITAMIN D; VITAMIN K GROUP;

ADULT; AGED; AGING; ARTICLE; BONE DENSITY; BONE MINERALIZATION; BONE REMODELING; BONE TURNOVER; CARBOXYLATION; CLINICAL TRIAL; CONTROLLED STUDY; DISEASE MARKER; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK FRACTURE; FRACTURE HEALING; HIP FRACTURE; HUMAN; KIDNEY FAILURE; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SECONDARY HYPERPARATHYROIDISM; VITAMIN DEFICIENCY;

AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; BONE AND BONES; BONE DENSITY; CALCANEUS; CALCIFEDIOL; CALCIUM, DIETARY; DOUBLE-BLIND METHOD; FEMALE; FEMUR NECK; HIP FRACTURES; HUMANS; MIDDLE AGED; OSTEOCALCIN; OSTEOMALACIA; TIME FACTORS;

EID: 0031931910     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002239900432     Document Type: Article

References (32)

1. Price PA, Parthemore JG, Deftos LJ, Nishimoto SK (1980) New biochemical marker for bone metabolism: measurement by radioimmunoassay of bone gla-protein in the plasma of normal subjects and patients with bone disease. J Clin Invest 66:878-883
2. Delmas PD (1993) Biochemical markers of bone turnover. J Bone Miner Res (Suppl) 2:S549-S555
3. Furie B, Furie BC (1990) Molecular basis of vitamin K-dependent gamma-carboxylation. Blood 75:1753-1762
4. Shearer MJ (1995) Vitamin K. Lancet 345:229-234
5. Price PA, Williamson MK, Lothringer JW (1981) Origin of the vitamin K-dependent bone protein found in plasma and its clearance by kidney and bone. J Biol Chem 256:12760-12766
6. Price PA (1993) Vitamin K nutrition and postmenopausal osteoporosis. J Clin Invest 91:1268
7. Robert D, Jorgetti V, Lacour B, Leclerq M, Cournot-Witmer G, Ulmann A, Drueke T (1985) Hypercalciuria during experimental vitamin K deficiency in the rat. Calcif Tissue Int 37:143-147
8. Lavelle PA, Lloyd QP, Gay CV, Leach RM (1994) Vitamin K deficiency does not functionally impair skeletal metabolism of laying hens and their progeny. J Nutr 124:371-377
9. Rosen HN, Maitland LA, Suttie JW, Manning WJ, Glynn RJ, Greenspan SL (1993) Vitamin K and maintenance of skeletal integrity in adults. Am J Med 94:62-68
10. Fiore CE, Tamburino C, Foti R, Grimaldi D (1990) Reduce bone mineral content in patients taking oral coagulant. South Med J 83:538-542
11. Plantalech L, Guillaumont M, Vergnaud P, Leclercq M, Delmas PD (1991) Impairment of gamma carboxylation of circulating osteocalcin (bone Gla protein) in elderly women. J Bone Miner Res 6:1211-1216
12. Szulc P, Chapuy M-C, Meunier PJ, Delmas PD (1993) Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest 91:1769-1774
13. Szulc P, Arlot M, Chapuy M-C, Duboeuf F, Meunier PJ, Delmas PD (1994) Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women. J Bone Miner Res 9:1591-1595
14. Turner CH, Peacock M, Timmerman L, Neal JM, Johnston CCJ (1995) Calcaneal ultrasonic measurements discriminate hip fracture independently of bone mass. Osteoporosis Int 5:130-135
15. Schott AM, Weill-Engerer S, Hans D, Duboeuf F, Delmas PD, Meunier PJ (1995) Ultrasound discriminates patients with hip fracture equally well as dual energy X-ray absorptiometry and independently of bone mineral density. J Bone Miner Res 10:243-249
16. Peacock M, Turner CH, Liu G, Manatunga AK, Timmerman L, Johnston CCJ (1995) Better discrimination of hip fracture using bone density, geometry and architecture. Osteoporosis Int 5:167-173
17. Gundberg CM, Weinstein RS (1986) Multiple immunoreactive forms of osteocalcin in uremic serum. J Clin Invest 77:1762-1767
18. Epstein S, Poser J, McClintock R, Johnston CC Jr, Bryce G, Hui S (1984) Differences in serum bone GLA protein with age and sex. Lancet 1:307-310
19. Orwoll ES, Deftos LJ (1990) Serum osteocalcin (BGP) levels in normal men: a longitudinal evaluation reveals un age- associated increase. J Bone Miner Res 5(3):259-262
20. Delmas PD, Stenner D, Wahner HW, Mann KG, Riggs BL (1983) Increase in scrum bone gamma-carboxyglutamic acid protein with aging in women. Implications for the mechanism of age-related bone loss. J Clin Invest 71:1316-1321
21. Khosla S, Atkinson EJ, Melton J III, Riggs BL (1997) Effects of uge and estrogen status on scrum parathyroid hormone levels and biochemical markers of bone turnover in women: a population-based study. J Clin Endocrinol Metab 82:1522-1527
22. Garnero P, Sornay-Rendu H, Chapuy M-C, Delmas PD (1996) Increased bone turnover in late postmenopausal women is a major determinant of Osteoporosis. J Bone Miner Res 11:337-349
23. Menon RK, Gill DS, Thomas M, Kernoff PBA, Dandona P (1987) Impaired carboxylation of osteocalcin in warfarin- treated patients. J Clin Endocrinol Metab 64:59-61
24. Knapen MHJ, Hamulyak K, Vermeer C (1989) The effect of vitamin K supplementation on circulating osteocalcin (bone Gla protein) and urinary calcium excretion. Ann Intern Med 111:1001-1005
25. Nyman MT, Paavolainen P, Forsius S, Lamberg-Allandte (1991) Clinical evaluation of fracture healing by serum osteocalcin and alkaline phosphatase. Ann Chir Gynaecol 80:289-293
26. Mallmin H, Ljunghall S, Larsson K (1993) Biochemical markers of bone metabolism in patients with fracture of the distal forearm. Clin Orthop 295:259-263
27. Akesson K, Vergnaud P, Delmas PD, Obrant KJ (1995) Serum osteocalcin increases during fracture healing in elderly women with hip fracture. Bone 16:427-430
28. Cairns JR, Price PA (1994) Direct demonstration that the vitamin K-dependent bone gla protein is incompletely γ-carboxylated in humans. J Bone Miner Res 9:1989-1997
29. Merle B, Delmas PD (1990) Normal carboxylation of circulating osteocalcin (bone gla-protein) in Paget's disease of bone. Bone Miner 11:237-245
30. McCarthy RN, Jeffcott LB, McCartney RN (1990) Ultrasound speed in equine cortical bone: effects of orientation, density, porosity and temperature. J Biomech 23:1139-1143
31. Heaney RP, Avioli LV, Chesnut CHI, Lappe J, Recker RR (1989) Osteoporotic bone fragility. JAMA 261(20):2986-2990
32. Hodges SJ, Pilkington MJ, Stamp TCB, Catterall A, Shearer MJ, Bitensky L, Chayen J (1991) Depressed levels of circulating menaquinones in patients with osteoporotic fractures of the spine and femoral neck. Bone 12:s387-389