A facile synthesis of (2R,3S)-1-amino-3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutane; A useful component block of HIV protease inhibitor

Synthetic Communications

Volumn 28, Issue 3, 1998, Pages 395-401

  Yuasa, Yoko ^a   Yuasa, Yoshifumi ^b   Tsuruta, Haruki ^b  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b TAKASAGO INTERNATIONAL CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 3 TERT BUTOXYCARBONYLAMINO 2 HYDROXY 4 PHENYLBUTANE; AMPRENAVIR; BUTANE; PROTEINASE INHIBITOR; SODIUM BOROHYDRIDE; TITANIUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS; HYDROGENATION; REDUCTION;

EID: 0031931437     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1080/00397919808005092     Document Type: Article

References (15)

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12. r = 9.9 and 10.6 min assignable to the (2R,3S)-and (2S,3S)-diastereomer, respectively.
13. 4 reduction of aromatic nitro compound, see: Kano, S.; Tanaka, Y.; Sugino, E.; Hibino. S. Synthesis, 1980, 695-697
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15. r = 13.9 and 15.1 min assignable to the (2S.3S)-and (2R,3S)-diastereomer, respectively.