Isolation and molecular characterization of porcine calcitonin gene- related peptide (CGRP) and its endocrine effects in the porcine pancreas

Pancreas

Volumn 16, Issue 2, 1998, Pages 195-204

  Rasmussen, Torben N ^b   Bersani, Maurizio ^b   Schmidt, Peter ^b   Thim, Lars ^b   Kofod, Hans ^b   Jørgensen, Per N ^b   Poulsen, Steen S ^b   Holst, Jens J ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NONE

Author keywords

Adrenal gland; Glucagon; Immunoneutralization; Insulin; Peptide purification; Peptide sequencing; Somatostatin

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; GLUCAGON; GLUCOSE; INSULIN; SOMATOSTATIN;

ADRENAL GLAND; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HORMONE RELEASE; NERVE FIBER; NONHUMAN; PANCREAS SECRETION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SWINE;

EID: 0031931249     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-199803000-00014     Document Type: Article

References (32)

1. Amara SG, Jonas V, Rosenfeld M. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 1982;298:240-4.
2. Rosenfeld MG, Mermod J-J, Amara SG, et al. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 1983;304:129-35.
3. Pettersson M, Ahrén B, Böttcher G, Sundler F. Calcitonin gene-related peptide: occurrence in pancreatic islets in the mouse and the rat and inhibition of insulin secretion in the mouse. Endocrinology 1986;119:865-9.
4. Sternini C, Brecha N. Immunocytochemical identification of islet cells and nerve fibers containing calcitonin gene-related peptide-like immunoreactivity in the rat pancreas. Gastroenterology 1986; 90:1155-63.
5. Su HC, Bishop AE, Power RF, Hamada Y, Polak JM. Dual intrinsic and extrinsic origins of CGRP- and NPY-immunoreactive nerves of rat gut and pancreas. J Neurosci 1987;7:2674-87.
6. Sternini C, De Giorgio R, Anderson K, et al. Species differences in the immunoreactive patterns of calcitonin gene-related peptide in the pancreas. Cell Tissue Res 1992;269:447-58.
7. Pettersson M, Ahrén B. Insulin and glucagon secretion in rats: effects of calcitonin gene-related peptide. Regul Pept 1988;23:37-50.
8. Ahrén B, Mårtensson H, Nobin A. Effects of calcitonin gene-related peptide (CGRP) on islet hormone secretion in the pig. Diabetologia 1987;30:354-9.
9. Dunning BE, Taborsky GJ Jr. Calcitonin gene-related peptide: a potent and selective stimulator of gastrointestinal somatostatin secretion. Endocrinology 1987;120:1774-81.
10. Hermansen K, Ahrén B. Dual effects of calcitonin gene-related peptide on insulin secretion in the perfused dog pancreas. Regul Pept 1990;27:149-57.
11. Kimura S, Sugita Y, Kanazawa I, Saito A, Goto K. Isolation and amino acid sequence of calcitonin gene-related peptide from porcine spinal cord. Neuropeptides 1987;9:75-82.
12. Bauerfeind P, Hof R, Hof A, et al. Effect of hCGRP I and II on gastric blood flow and acid secretion in anesthetized rabbits. Am J Physiol 1989;256:G145-9.
13. Beglinger C, Born W, Hildebrand P, et al. Calcitonin gene-related peptides I and II and calcitonin: distinct effects on gastric acid secretion in humans. Gastroenterology 1989;95:958-65.
14. Beglinger C, Born W, Münch R, et al. Distinct hemodynamic and gastric effects of human CGRP I and II in man. Peptides 1991;12: 1347-51.
15. Rasmussen TN, Bersani M, Johnsen AH, Kofod H, Holst JJ. Pigs produce only a single form of CGRP, part of which is processed to N- and C-terminal fragments. Peptides 1994;15:89-94.
16. Newgard CB, Holst JJ. Heterogeneity of somatostatin-like immunoreactivity (SLI) in extracts of porcine, canine and human pancreas. Acta Endocrinol (Copenh) 1981;98:564-72.
17. Thim L, Hansen MT, Sorensen AR. Secretion of human insulin by transformed yeast cell. FEBS Lett 1987;212:307-12.
18. Sundquist BUR, Kamensky I, Håkonsson O, et al. Californium-252 plasma desorption time of flight mass spectrometry of proteins. Biomed Environ Mass Spectrosc 1984;11:242-57.
19. Jonsson GP, Hedin AB, Håkonsson O, et al. Plasma desorption mass spectrometry of peptides and proteins adsorbed on nitrocellulose. Anal Chem 1986;58:1084-7.
20. Nielsen PF, Klarskov K, Hojrup P, Roepstorff P. Optimization of sample preparation for plasma desorption mass spectrometry of peptides and proteins using a nitrocellulose matrix. Biomed Environ Mass Spectrosc 1988;17:355-62.
21. Roepstorff P. Plasma desorption mass spectrometry of large biomolecules. J Pharm Biomed Anal 1989;7:247-53.
22. Dyrberg T, Kofod H. Synthetic peptides as antigens. In: Olstone MBA, ed. Animal virus pathogenesis, a practical approach. Oxford: IRL Press, 1990:163-71.
23. Jensen SL, Fahrenkrug J, Holst JJ, Kuhl C, Nielsen OV, Schaffalitzky de Muckadell OB. Secretory effects of secretin on isolated perfused porcine pancreas. Am J Physiol 1978;235:E381-6.
24. Hilsted L, Holst JJ. On the accuracy of radioimmunological determination somatostatin in plasma. Regul Pept 1982;4:13-31.
25. Holst JJ, Jørgensen PN, Rasmussen TN, Schmidt P. Somatostatin restraint of gastrin secretion in pigs revealed by monoclonal antibody immunoneutralization. Am J Physiol 1992;263:G908-12.
26. Mulderry PK, Ghatei MA, Spokes RA, et al. Differential expression of α-CGRP and β-CGRP by primary sensory neurons and enteric autonomic neurons of the rat. Neuroscience 1988;1:195-205.
27. Fisher JA, Born W. Novel peptides from the calcitonin gene: expression, receptors and biological function. Peptides 1985;6:265-71.
28. Mèssell T, Harling H, Böttcher G, Johnsen AH, Holst JJ. Galanin in the porcine pancreas. Regul Pept 1990;28:161-76.
29. Ishizuka J, Greeley Jr GH, Cooper CW, Thompson JC. Effect of calcitonin gene-related peptide on glucose and gastric inhibitory polypeptide-stimulated insulin release from cultured newborn and adult rat islet cells. Regul Pept 1988;20:73-82.
30. Pettersson M, Ahrén B. Calcitonin gene-related peptide inhibits glucose-stimulated insulin secretion in the rat in vivo and in vitro. Diabetologia 1988;31:531.
31. Palmer JM, Schemann M, Tamura K, Wood JD. Calcitonin gene-related peptide excites myenteric neurons. Eur J Pharmacol 1986; 13:163-70.
32. Lewis CA, Clark A, Ashcroft SJH, Cooper GJS, Morris JF. Calcitonin gene-related peptide and somatostatin inhibit insulin release from individual rat B cells. Cell Endocrinol 1988;57:41-9.