Genotoxicological monitoring of 175 subjects living in the green belts, inner town or near chemical industrial estates in Greater Budapest agglomeration, Hungary

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 412, Issue 1, 1998, Pages 9-16

  Major, J ^a   Jakab, M G ^a   Tompa, Anna ^a  

^a National Institute of Occupational Health Budapest   (Hungary)

Author keywords

Cell proliferation; Chromosome aberration; Historical control; Human lymphocyte; Industrial control; Residential area; Sister chromatid exchange; UV light induced DNA repair

Indexed keywords

ADULT; AGED; ARTICLE; CHEMICAL INDUSTRY; CHROMOSOME ABERRATION; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; HUNGARY; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MITOSIS; NORMAL HUMAN; POLLUTANT; PRIORITY JOURNAL; RURAL AREA; SEASONAL VARIATION; SISTER CHROMATID EXCHANGE; URBAN AREA;

ADULT; ALCOHOL DRINKING; CELL CYCLE; CELLS, CULTURED; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; HUNGARY; HYDROXYUREA; INDUSTRY; KINETICS; LYMPHOCYTES; MALE; MITOTIC INDEX; MUTAGENICITY TESTS; PATIENT SELECTION; SISTER CHROMATID EXCHANGE; SMOKING; SUBURBAN POPULATION; ULTRAVIOLET RAYS; URBAN POPULATION;

EID: 0031931120     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(97)00153-8     Document Type: Article

References (22)

1. American Cancer Society, Cancer Facts and Figures, American Cancer Society, 1990.
2. Bender M.A., Preston R.J., Leonard R.C., Pyatt B.E., Gooch P.C., Shelby M.D. Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample. Mutation Res. 204:1988;421-433.
3. Carrano A.V., Natarajan A.T. Considerations for population monitoring using cytogenetic techniques, ICPEMC Publ. No. 14. Mutation Res. 204:1988;379-406.
4. Ganguly B.B. Cell division, chromosome damage and micronucleus formation in peripheral lymphocytes of healthy donors: related to donors' age. Mutation Res. 295:1993;135-148.
5. Goldsmith J.R. The "urban factor" in cancer: Smoking, industrial exposures, and air pollution as possible explanations. J. Environ. Pathol. Toxicol. 3:1980;205-217.
6. S. Gundy, E. Susánszky, J. Major, E. Czeizel, Cytogenetic monitoring, in: M. Richardson (Ed.), Chemical Safety, VCH Publ., Weinheim, New York, 1994, pp. 227-240.
7. Hassanien M.A., Horváth A. Comparison of indoor-outdoor air lead pollution for an urban area in Budapest. Central Eur. J. Occup. Environ. Med. 1:1995;68-77.
8. Hassanien M.A., Horváth A., Kertész M. Evaluation of the current status of selected air pollutants related to an urban area, Budapest, Hungary. Central Eur. J. Occupat. Environ. Med. 2:1996;54-63.
9. Jakab M.G., Major J., Tompa A. HPRT mutation frequencies in control human populations in Hungary. Central Eur. J. Occupat. Environ. Med. 2:1996;317-328.
10. Kertész M. The role of the National Institute of Hygiene in the research of air pollutant carcinogens ("Fenyvesi Béla" Memorial Lecture). Egészségtudomány. 38:1994;207-214. (in Hungarian, abstract in English).
11. Major J., Jakab M., Kiss G., Tompa A. Chromosome aberration, sister-chromatid exchange, proliferative rate index and serum thiocyanate concentration in smokers exposed to low-dose benzene. Environ. Mol. Mutagen. 23:1994;137-142.
12. Major J., Jakab M.G., Tompa A. Genotoxicological investigation of hospital nurses occupationally exposed to ethylene-oxide: I. Chromosome aberrations, sister-chromatid exchanges, cell cycle kinetics, and UV-induced DNA synthesis in peripheral blood lymphocytes Environ. Mol. Mutagen. 27:1996;84-92.
13. Major J., Jakab M.G., Tompa A. Multiple end-point genotoxicology monitoring of Hungarian historical and industrial control subjects. Central Eur. J. Occupat. Environ. Med. 3:1997;87-101.
14. Molnár A., Mészáros E., Koltay E. Elemental composition of atmospheric aerosols in Budapest. Egészségtudomány. 38:1994;235-239. (in Hungarian, abstract in English).
15. NIMN Data of the "National Immission Measuring Network" Egészségtudomány. 36:1992;290-294. (in Hungarian).
16. NIMN Data of the "National Immission Measuring Network" Egészségtudomány. 38:1994;282-295. (in Hungarian).
17. R. Reiniger, Overview of Hungary's environmental situation, in: Proc. Int. Symp. on Environmental Contamination in Central and Eastern Europe, Budapest, 1992, pp. 13-15.
18. Tompa A., Farkas I. New "morbus hungaricus"? The role of working environment in development of neoplastic diseases. Hung. Sci. 1992(11):1992;1310-1324. (in Hungarian).
19. Tompa A., Major J., Jakab M. Monitoring of benzene-exposed workers for genotoxic effects of benzene: Improved-working-condition-related decrease in the frequencies of chromosomal aberrations in peripheral blood lymphocytes. Mutation Res. 304:1994;159-165.
20. Tompa A., Sápi E. Detection of 6-thioguanine resistance in human peripheral blood lymphocytes (PBL) of industrial workers and lung cancer patients. Mutation Res. 210:1989;345-351.
21. S.R. Wassersug, Environmental transformation in Central and Eastern Europe, in: Proc. Int. Symp. on Environmental Contamination in Central and Eastern Europe, Budapest, 1992, pp. 7-13.
22. WHO, World Health Statistics Annuals 1984-88, World Health Organisation, Geneva, 1988.