Topical use of zinc desferrioxamine for corneal alkali injury in a rabbit model

Cornea

Volumn 17, Issue 2, 1998, Pages 191-195

  Siganos, Charalambos S ^a,c   Frucht Pery, Joseph ^a   Muallem, M S ^a   Berenshtein, Eduard ^b   Naoumidi, Irene ^c   Ever Hadani, Pnina ^b   Pallikaris, Ioannis G ^c   Siganos, Dimitrios S ^c   Chevion, Mordechai ^b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HEBREW UNIVERSITY   (Israel)

^c UNIVERSITY OF CRETE   (Greece)

Author keywords

Alkali injury; Corneal ulcer; Free radical inhibitors; Rabbit; Zinc desferrioxamine

Indexed keywords

ALKALI; ANTIBIOTIC AGENT; BICARBONATE; DEFEROXAMINE; FREE RADICAL; GENTAMICIN; ZINC DERIVATIVE;

ADJUVANT THERAPY; ANIMAL MODEL; ARTICLE; CHEMICAL INJURY; CONTROLLED STUDY; CORNEA BURN; CORNEA INJURY; CORNEA ULCER; EXPERIMENTAL MODEL; NONHUMAN; PRIORITY JOURNAL; RABBIT; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

EID: 0031931076     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003226-199803000-00013     Document Type: Article

References (35)

1. Hughes WF. Alkali burns of the eye: II. clinical and pathological course. Arch Ophthalmol 1946;36:189-214.
2. Beshara SJ, Kara-Jose N, Pettinati AH. Therapeutic use of contact lenses in alkali burns of the cornea. Cornea 1987;6(2):117-21.
3. Phan TM, Foster S, Shaw CD, Zagachin LM, Colvin RB. Topical fibronectin in an alkali burn model of corneal ulceration in rabbits. Arch Ophthalmol 1991;109:414-9.
4. Chung JH, Fagerholm P. Treatment of rabbit corneal alkali wounds with human epidermal growth factor. Cornea 1989;8(2):122-8.
5. Brazzel RK, Stern ME, Aquavella JV, Beuerman RW, Baird L. Human recombinant epidermal growth factor in experimental corneal wound healing. Invest Ophthalmol Vis Sci 1991;32:336-40.
6. Pfister RR, Haddox JL, Dadson RW, Deshazo WF. Polymorphonuclear leukocytic inhibition by citrate, other metal chelators, and trifluoperazine. Invest Ophthalmol Vis Sci 1984;25:955-70.
7. Pfister RR, Haddox JL, Lank KM. Citrate or ascorbate/citrate treatment of established corneal ulcers in the alkali-injured rabbit eye. Invest Ophthalmol Vis Sci 1988;29:1110-5.
8. Pfister RR, Haddox JL, Yuille-Bar D. The combined effect of citrate/ascorbate treatment in alkali-injured rabbit eyes. Cornea 1991;10(2):100-4.
9. 2 levels. Br J Ophthalmol 1984;68:656-9.
10. Brown SI, Weller CA. Collagenase inhibitors in prevention of ulcers of alkali-burned cornea. Arch Ophthalmol 1970;83:352-3.
11. Francois J, Cambie E, Feher J, Van den Eeckhout E. Penicillamine in the treatment of alkali burned corneas. Ophthalmic Res 1972/ 1973;4:223-36.
12. Seedor JA, Perry HD, McNamara TF, Golub LM, Buxton DF, Guthrie DS. Systemic tetracycline treatment of alkali-induced corneal ulceration in rabbits. Arch Ophthalmol 1987;105:268-71.
13. Slansky HH, Berman MB, Dohlman CH, Rose J. Cysteine and acetylcysteine in the prevention of corneal ulcerations. Ann Ophthalmol 1970;2:488.
14. Burns FR, Gray RD, Paterson CA. Inhibition of alkali-induced corneal ulceration and perforation by a thiol peptide. Invest Ophthalmol Vis Sci 1990;31:107-14.
15. Wentworth JS, Paterson CA, Gray RD. Effect of a metalloproteinase inhibitor on established corneal ulcers after an alkali burn. Invest Ophthalmol Vis Sci 1992;33:2174-9.
16. Schultz GS, Strelow S, Stern A, et al. Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases. Invest Ophthalmol Vis Sci 1992;33:3325-31.
17. Paterson CA, Wells JG, Koklitis PA, Higgs GA, Docherty AJP. Recombinant tissue inhibitor of metalloproteinases type 1 suppresses alkali burn-induced corneal ulceration in rabbits. Invest Ophthalmol Vis Sci 1994;35:677-84.
18. Hayden BJ, Zhu L, Sens D, Tapert MJ, Crouch RK. Cytolysis of corneal epithelial cells by hydrogen peroxide. Exp Eye Res 1990; 50:11-6.
19. Nirankari VS, Shambu DV, Lakhanpal V, Richards RD. Superoxide radical scavenging agents in treatment of alkali burns. Arch Ophthalmol 1981;99:886-7.
20. Carubelli R, Nordquist R, Rowsey JJ. Role of active oxygen species in corneal ulceration. Cornea 1990;9(2):161-9.
21. Kirkpatrick D, McGinnes J. A superoxide producing system in the conjunctival mucous thread. Invest Ophthalmol Vis Sci 1972;11: 762-5.
22. Chevion M. A site-specific mechanism for free radical induced biological damage: the essential role of redox-active transition metals. Free Radic Biol Med 1988;5:27-37.
23. Chevion M. Protection against free radical-induced and transition metal-mediated damage: the use of "pull" and "push" mechanisms. Free Radic Res Commun 1991;12-13:691-6.
24. Ophir A, Berenshtein E, Kitrossky N, Everbukh E. Protection of the transiently ischemic cat retina by zinc-desferrioxamine. Invest Ophthalmol Vis Sci 1994;35:1212-22.
25. Jiang Y, Schwalb H, Uretzy G, Chevion M. The combination of zinc and desferrioxamine provides protection to the heart via both "push" and "pull" mechanisms [Abstract]. J Mol Cell Cardiol 1991;23(suppl V):S2.
26. Jiang Y, Uretzy G, Borman JB, Chevion M. Protection via "push" and "pull" mechanisms: II: the effect of zinc and desferrioxamine on heart following global ischaemia and reperfusion [Abstract]. J Mol Cell Cardiol 1992;24:S1.
27. Pfister RR, Paterson CA, Hayes SA. Topical ascorbate decrease the incidence of corneal ulceration after experimental alkali burns. Invest Ophthalmol Vis Sci 1978;17:1019-24.
28. Varma SD, Ets TK, Richards RD. Protection against superoxide radicals in rat lens. Ophthalmic Res 1972;9:421-3.
29. Fridovich I. Biology of oxygen radicals. Science 1978;201:875-80.
30. Chevion M, Chuang L, Golenser J. Effects of zinc desferrioxamine on Plasmodium falciparum in culture. J Antimicrob Chemother 1995;8:1902-5.
31. Karcioglou ZA. Zinc in the eye. Surv Ophthalmol 1982;27:114-22.
32. Pories WT, Shear EW, Jordan DR, et al. The measurement of human wound healing. Surgery 1966;59:821-4.
33. Van Rij AM, Pories WJ. Zinc and copper in surgery. In: Karcioglu ZA, Sarper RM, eds. Zinc and copper in medicine. Springfield, IL: Charles C Thomas, 1980:535-78.
34. Hubbard GB, Herron BE, Andrews JS, et al. Influence of topical and oral zinc upon corneal wound healing. Br J Ophthalmol 1969; 53:407-11.
35. Solomon NW. Zinc and copper in human nutrition. In: Karcioglu ZA, Sarper RM, eds. Zinc and copper in medicine. Springfield, IL: Charles C Thomas, 1980:224-75.