Effect of captopril on platelet cytosolic [Ca2+](i) and plasma TXA2/PGI2 in renovascular hypertensive rats

Acta Pharmacologica Sinica

Volumn 19, Issue 1, 1998, Pages 89-91

  Wei, Xiang Rong ^a,b   Hu, Lian ^a   Du, Jian ^a,b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b Shanghai Institute of Hypertension   (China)

Author keywords

Angiotensin II; Blood pressure; Calcium; Captopril; Epoprostenol; Platelet aggregation; Renovascular hypertension; Synthetic prostaglandins F; Thromboxane A2

Indexed keywords

ANGIOTENSIN; CALCIUM ION; CAPTOPRIL; FURA 2 ACETOXYMETHYL ESTER; PROSTACYCLIN; THROMBOXANE A2;

ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG EFFECT; NONHUMAN; PLASMA; RADIOIMMUNOASSAY; RAT; RENOVASCULAR HYPERTENSION; THROMBOCYTE; THROMBOCYTE AGGREGATION;

ANGIOTENSIN II; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PLATELETS; BLOOD PRESSURE; CALCIUM; CAPTOPRIL; EPOPROSTENOL; FEMALE; HYPERTENSION, RENOVASCULAR; MALE; PLATELET AGGREGATION; RATS; RATS, WISTAR; THROMBOXANE A2;

EID: 0031930948     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Parratt JR. Cardioprotection by angiotensin converting enzyme inhibitors-the experimental evidence. Caidiovasc Res 1994; 28: 183-9.
2. Haller H, Oeneg T, Hauck V, Distler A, Phillip T. Increased intracellular free calcium and sensitivity to angiotensin II in platelets of preeclamptic women. Am J Hypertens 1989; 2: 238-43.
3. James IM, Dickenson EJ, Burgoyne W, Jeremy JY, Barradas MA, Mikhailidis DP, et al. Treatment of hypertension with captopril: preservation of regional blood flow and reduced platelet aggregation. J Hum Hypertens 1988; 2: 21-5.
4. Morishita R, Higaki J, Miyazaki M, Qgihara T. Possible role of the vascular renin-angiotensin system in hypertension and vascular hypertension. Hypertension 1992; 19 Suppl 2: 1162-7.
5. Gu TG, Gu TH, Song DJ, Zhang WZ, Kuan AK. The measurement of blood pressure from trial hypertensive rats. Acta Univ Med Sec Shanghai 1985; 5: 102-4.
6. Hu WY, Chen DG, Chen SC, Tin XQ, Wang HJ. Effect of chronic captopril treatment on circulating and tissue renin-angiotensin system in SHR rats. Acta Pharmacol Sin 1996; 17: 507-12.
7. Wang ZY, Ruan CG. Test of platelet aggregation. In: Wang ZY, Li JZ, Ruan CG, editors. Thrombosis and Haemostasis - basic theory and clinic; vol 2. Shanghai: Shanghai Scientific & Technical Publ; 1996. p 201-2.
8. Oshima T, Young EW, Bukoski RD, McCarron DA. Abnormal calcium handling by platelets of spontaneously hypertensive rats. Hypertension 1990; 15: 606-11.
9. Oshima T, Young EW, McCarron DA. Abnormal platelet and lymphocyte calcium handling in prehypertensive rats. Hypertension 1991; 18: 111-5.
10. 1α concentration in patients with essential and renovoscular hypertension. Chin J Cardiol 1986; 14: 23-5.