Skeletal effects of low-dose cyclosporin a in aged male rats: Lack of relationship to serum testosterone levels

Journal of Bone and Mineral Research

Volumn 13, Issue 1, 1998, Pages 79-87

  Erben, Reinhold G ^a   Stangassinger, Manfred ^a   Gärtner, Roland ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; CREATININE; CYCLOSPORIN A; OSTEOCALCIN; PARATHYROID HORMONE; TESTOSTERONE;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE TURNOVER; CANCELLOUS BONE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; LUMBAR VERTEBRA; MALE; NONHUMAN; OSTEOPENIA; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

AGING; ANIMALS; BODY WEIGHT; BONE AND BONES; CALCIFICATION, PHYSIOLOGIC; CELL COUNT; CYCLOSPORINE; EATING; INJECTIONS, SUBCUTANEOUS; LINEAR MODELS; MALE; OSTEOCLASTS; OSTEOGENESIS; RATS; RATS, WISTAR; TESTOSTERONE;

EID: 0031930171     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1998.13.1.79     Document Type: Article

References (34)

1. Epstein S 1996 Post-transplantation bone disease: The role of immunosuppressive agents and the skeleton. J Bone Miner Res 11:1-7.
2. Thiébaud D, Krieg MA, Gillard-Berguer D, Jacquet AF, Goy JJ, Burckhardt P 1996 Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantation. Eur J Clin Invest 26:549-555.
3. Lukert BP, Raisz LG 1990 Glucocorticoid-induced osteoporosis: Pathogenesis and management. Ann Intern Med 112: 352-364.
4. Movsowitz C, Epstein S, Fallon M, Ismail F, Thomas S 1988 Cyclosporin-A in vivo produces severe osteopenia in the rat: Effect of dose and duration of administration. Endocrinology 123:2571-2577.
5. 3 modifies cyclosporine-induced bone loss. Calcif Tissue Int 47:152-157.
6. Movsowitz C, Epstein S, Fallon M, Ismail F, Thomas S 1990 The bisphosphonate 2-PEBP inhibits cyclosporin A induced high-turnover osteopenia in the rat. J Lab Clin Med 115:62-68.
7. Katz I, Li M, Joffe I, Stein B, Jacobs T, Liang XG, Ke HZ, Jee W, Epstein S 1994 Influence of age on cyclosporin A-induced alterations in bone mineral metabolism in the rat in vivo. J Bone Miner Res 9:59-67.
8. Homan WP, Fabre JW, Williams KA, Millard PR, Morris PJ 1980 Studies on the immunosuppressive properties of cyclosporin A in rats receiving renal allografts. Transplantation 29:361-366.
9. Hall BM, Jelbart ME, Gurley KE, Dorsch SE 1985 Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine: Mediation of specific suppression by T helper/inducer cells. J Exp Med 162:1683-1694.
10. Del Pozo E, Lippuner K, Ruch W, Casez JP, Payne T, Mac-Kenzie A, Jaeger P 1995 Different effects of cyclosporin A on bone remodeling in young and adult rats. Bone 16:271S-275S.
11. Orcel P, Bielakoff J, Modrowski D, Miravet L, de Vernejoul MC 1989 Cyclosporin A induces in vivo inhibition of resorption and stimulation of formation in rat bone. J Bone Miner Res 4:387-391.
12. Klein L, Lemel MS, Wolfe MS, Shaffer J 1994 Cyclosporin A does not affect the absolute rate of cortical bone resorption at the organ level in the growing rat. Calcif Tissue Int 55:295-301.
13. Cavallini L, Malendowicz LK, Mazzocchi G, Belloni AS, Nussdorfer GG 1990 Effects of prolonged cyclosporine-A treatment on the Leydig cells of the rat testis. Virchows Arch B Cell Pathol 58:215-220.
14. Seethalakshmi L, Flores C, Carboni AA, Bala R, Diamond DA, Menon M 1990 Cyclosporine: Its effects on testicular function and fertility in the prepubertal rat. J Androl 11:17-24.
15. Krueger BA, Trakshel GM, Sluss PM, Maines MD 1991 Cyclosporin-mediated depression of luteinizing hormone receptors and heme biosynthesis in rat testes: A possible mechanism for decrease in serum testosterone. Endocrinology 129:2647-2654.
16. Erben RG 1997 Embedding of bone samples in methylmeth-acrylate: An improved method suitable for bone histomorphometry, histochemistry, and immunohistochemistry. J Histochem Cytochem 45:307-312.
17. Baron R, Vignery A, Neff L, Silverglate A, Santa Maria A 1983 Processing of undecalcified bone specimens for bone histomorphometry. In: Recker RR (ed.) Bone Histomorphometry: Techniques and Interpretation. CRC Press, Boca Raton, FL, U.S.A., pp. 13-35.
18. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR 1987 Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595-610.
19. Parfitt AM 1984 Age-related structural changes in trabecular and cortical bone: Cellular mechanisms and biomechanical consequences. Calcif Tissue Int 36:S123-S128.
20. Sambrook PN, Kelly PJ, Keogh AM, Macdonald P, Spratt P, Freund J, Eisman JA 1994 Bone loss after heart transplantation: A prospective study. J Heart Lung Transplant 13:116-120.
21. Erben RG 1996 Trabecular and endocortical bone surfaces in the rat: Modeling or remodeling? Anat Rec 246:39-46.
22. Canalis E 1996 Mechanisms of glucocorticoid action in bone: Implications to glucocorticoid-induced osteoporosis. J Clin Endocrinol Metab 81:3441-3447.
23. Buchinsky FJ, Ma YF, Mann GN, Rucinski B, Bryer HP, Romero DF, Jee WSS, Epstein S 1996 T lymphocytes play a critical role in the development of cyclosporin A-induced osteopenia. Endocrinology 137:2278-2285.
24. 3 in the rat and mouse. Endocrinology 128:1369-1373.
25. Reichel H, Grussinger A, Knehans A, Kuhn K, Schmidt Gayk H, Ritz E 1992 Long-term therapy with cyclosporin A does not influence serum concentrations of vitamin D metabolites in patients with multiple sclerosis. Clin Invest 70:595-599.
26. Dumoulin G, Hory B, Nguyen NU, Henriet M-T, Bresson C, Regnard J, Saint-Hillier Y 1995 Lack of evidence that cyclosporine treatment impairs calcium-phosphorus homeostasis and bone remodeling in normocalcemic long-term renal transplant recipients. Transplantation 59:1690-1694.
27. Hahn HJ, Laube R, Lucke S, Besch W 1992 Alteration of pancreatic B-cells in Wistar rats treated with non-diabetogenic doses of cyclosporin A. Pharmacol Toxicol 70:188-191.
28. Sigalet DL, Kneteman NM, Thomson AB 1992 Reduction of nutrient absorption in normal rats by cyclosporine. Transplantation 53:1103-1107.
29. Epstein S, Takizawa M, Stein B, Katz IA, Joffe II, Romero DF, Liang XG, Li M, Ke HZ, Jee WSS, Jacobs TW, Berlin J 1994 Effect of cyclosporin A on bone mineral metabolism in experimental diabetes mellitus in the rat. J Bone Miner Res 9:557-566.
30. Bowman AR, Sass DA, Dissanayake IR, Ma YF, Liang H, Yuan Z, Jee WSS, Epstein S 1997 The role of testosterone in cyclosporine-induced osteopenia. J Bone Miner Res 12: 607-615.
31. Handelsman DJ, McDowell IF, Caterson ID, Tiller DJ, Hall BM, Turtle JR 1984 Testicular function after renal transplantation: Comparison of Cyclosporin A with azathioprine and prednisone combination regimes. Clin Nephrol 22:144-148.
32. Schmidt JB, Gebhart W, Kopsa H, Spona J 1986 Does cyclosporin A influence sex hormone level? Exp Clin Endocrinol 88:207-211.
33. Peces R, de la Torre M, Urra JM 1994 Pituitary-testicular function in cyclosporin-treated renal transplant patients. Nephrol Dial Transplant 9:1453-1455.
34. Muchmore JS, Cooper DK, Ye Y, Schlegel V, Prihil A, Zuhdi N 1992 Prevention of loss of vertebral bone density in heart transplant patients. J Heart Lung Transplant 11:959-963