Presynaptic GABA(B) receptor modulation of glutamate exocytosis from rat cerebrocortical nerve terminals: Receptor decoupling by protein kinase

Journal of Neurochemistry

Volumn 70, Issue 4, 1998, Pages 1513-1522

  Perkinton, Michael S ^a,c   Sihra, Talvinder S ^a,b  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c GUY S HOSPITAL   (United Kingdom)

Author keywords

( ) Baclofen; Ca2+ channels; GABA(B) receptor; Glutamate exocytosis; Protein kinase C; Synaptosomes

Indexed keywords

3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; 4 AMINOPYRIDINE; BACLOFEN; CALCIUM CHANNEL; CALCIUM ION; CARBOCYANINE; GLUTAMIC ACID; IONOMYCIN; PERTUSSIS TOXIN; PHACLOFEN; POTASSIUM CHLORIDE; PRESYNAPTIC RECEPTOR; PROTEIN KINASE C; SODIUM ION; TETRODOTOXIN;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SYNAPTOSOME; CALCIUM TRANSPORT; CONTROLLED STUDY; EXOCYTOSIS; MALE; NERVE ENDING; NERVE FIBER MEMBRANE POTENTIAL; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SECOND MESSENGER;

EID: 0031929939     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.70041513.x     Document Type: Article

References (69)

1. 2-(5). J. Neurochem. 48, 552-559.
2. Andrade R., Malenka R. C., and Nicoll R. A. (1986) A G-protein couples serotonin and GABA-B receptors to the same channel in hippocampus. Science 234, 1261-1265.
3. 1 receptor inhibition of glutamate exocytosis and protein kinase C-mediated decoupling. J. Neurochem. 60, 1081-1086.
4. Bean B. P. (1989) Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature 340, 153-155.
5. B receptor subtypes in the rat cerebral cortex J. Pharmacol. Exp. Ther. 262, 114-118.
6. B receptor. J. Pharmacol. Exp. Ther. 265, 765-770.
7. B receptors. Trends Pharmacol. Sci. 14, 259-261.
8. B autoreceptors in rat cortex synaptosomes: response under different depolarizing and ionic conditions. Eur. J. Pharmacol. 172, 41-49.
9. B receptors and their significance in mammalian pharmacology. Trends Pharmacol. Sci. 10, 401-406.
10. Bowery N. G., Hill D. R., Hudson A. L., Doble A., Middlemiss D. N., Shaw J., and Turnbull M. (1980) (-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor. Nature 283, 92-94.
11. Bowery N. G., Hudson A. L., and Price G. W. (1987) GABA-A and GABA-B receptor site distribution in the rat CNS. Neuroscience 20, 365-383.
12. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
13. Brown A. M. and Birnbaumer L. (1990) Ionic channels and their regulation by G protein subunits. Annu. Rev. Physiol. 52, 197-213.
14. Budd D. C. and Nicholls D. G. (1995) Protein kinase C-mediated suppression of the presynaptic adenosine A1 receptor by a facilitatory metabotropic glutamate receptor. J. Neurochem. 65, 615-621.
15. Colmers W. F. and Williams J. T. (1988) Pertussis toxin pretreatment discriminates between pre- and postsynaptic actions of baclofen in rat dorsal raphe nucleus in vitro. Neurosci. Lett. 93, 300-306.
16. Dittman J. S. and Regehr W. G. (1996) Contributions of calcium-dependent and calcium-independent mechanisms to presynaptic inhibition at a cerebellar synapse. J. Neurosci. 16, 1623-1633.
17. 2+ current in excitable cells. Trends Neurosci. 19, 35-43.
18. Dolphin A. C. and Scott R. H. (1986) Inhibition of calcium currents in cultured rat dorsal root ganglion neurones by (-)-baclofen. Br. J. Pharmacol. 88, 213-220.
19. Dolphin A. C. and Scott R. H. (1987) Calcium channel currents and their inhibition by (-)baclofen in rat sensory neurones: modulation by guanine nucleotides. J. Physiol. (Lond.) 386, 1-18.
20. Dolphin A. C., McGuirk S. M., and Scott R. H. (1989) An investigation into the mechanisms of inhibition of calcium channel currents in cultured sensory neurones of the rat by guanine nucleotide analogues and (-)-baclofen. Br. J. Pharmacol. 97, 263-273.
21. Dunlap K. and Fischbach G. D. (1981) Neurotransmitters decrease the calcium conductance activated by depolarization of embryonic chick sensory neurones. J. Physiol. (Lond.) 317, 519-535.
22. 2+ channels in mammalian central neurons. Trends Neurosci. 18, 89-98
23. B receptors in the hippocampus have different pharmacological properties. Neuron 1, 585-591.
24. B receptor-mediated inhibition of synaptic transmission in the hippocampus: pharmacology and intracellular mechanisms, in Presynpatic Receptors in the Mammalian Brain (Dunwiddie T. V. and Lovinger D. M., eds), pp. 14-26. Birkhauser, Boston.
25. Fox S., Krnjevic K., Morris M. E., Puil E., and Werman R. (1978) Action of baclofen on mammalian synaptic transmission. Neuroscience 3, 495-515.
26. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450.
27. Haas H. L., Greene R. W., and Olpe H. R. (1985) Stereoselectivity of L-baclofen in hippocampal slices of the rat. Neurosci. Lett. 55, 1-4.
28. Herrero I., Miras-Portugal M. T., and Sanchez-Prieto J. (1992) Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation. Nature 360, 163-166.
29. c but not in cAMP mediates L-AP4 inhibition of glutamate release: PKC-mediated suppression of this inhibitory pathway. Eur. J. Neurosci. 8, 700-709.
30. B sites in rat brain. Nature 290, 149-152.
31. Huston E., Cullen G., Sweeney M. I., Pearson H., Fazeli M. S., and Dolphin A. C. (1993) Pertussis toxin treatment increases glutamate release and dihydropyridine binding sites in cultured rat cerebellar granule neurons. Neuroscience 52, 787-798.
32. Isaacson J. S., Solis J. M., and Nicoll R. A. (1993) Local and diffuse synaptic actions of GABA in the hippocampus. Neuron 10, 165-175.
33. 2+-activated Rb-86-efflux in cultured spinal cord neurons via G-protein mechanism. Brain Res. 506, 181-186.
34. Katada T., Gilman A. G., Watanabe Y., Bauer S., and Jakobs K. H. (1985) Protein kinase C phosphorylates the inhibitory guanine nucleotide binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase. Eur. J. Biochem. 151, 431-437.
35. B receptors uncovers similarity to metabotropic glutamate receptors. Nature 386, 239-246.
36. Komulainen H. and Bondy S. C. (1987) The estimation of free calcium within synaptosomes and mitochondria with fura-2; comparison to quin-2. Neurochem. Int. 10, 55-64.
37. Lanthorn T. H. and Cotman C. W. (1981) Baclofen selectively inhibits excitatory synaptic transmission in the hippocampus. Brain Res. 225, 171-178.
38. B-receptor modulation of N-type calcium channels in cultured dorsal root ganglion neurons. Pflugers Arch. 425, 335-343.
39. Minta A. and Tsien R. Y. (1989) Fluorescent indicators for sodium. J. Biol. Chem. 264, 19449-19457.
40. B receptors. Int. Rev. Neurobiol. 36, 97-223.
41. Nicholls D. G. and Coffey E. T. (1994) Glutamate exocytosis from isolated nerve terminals. Adv. Second Messenger Phosphoprotein Res. 29, 189-203.
42. Nicholls D. G. and Sihra T. S. (1986) Synaptosomes possess an exocytotic pool of glutamate. Nature 321, 772-773.
43. Nicholls D. G., Sihra T. S., and Sanchez-Prieto J. (1987) Calcium-dependent and -independent release of glutamate from synaptosomes monitored by continuous fluorometry. J. Neurochem. 49, 50-57.
44. Olpe H. R., Demieville H., Baltzer V., Bencze W. L., Koella W. P., Wolf P., and Haas H. L. (1978) The biological activity of d- and l-baclofen (Lioresal). Eur. J. Pharmacol. 52, 133-136.
45. Olpe H. R., Karlsson G., Pozza M. F., Brugger F., Steinmann M., van Riezen H., Fagg G., Hall R. G., Froestl W., and Bittiger H. (1990) CGP 35348: a centrally active blocker of GABA-B receptors. Eur. J. Pharmacol. 187, 27-38.
46. B) receptor subtype. Brain Res. 604, 325-330.
47. Pierau F. K. and Zimmermann P. (1973) Action of a GABA-derivative on postsynaptic potentials and membrane properties of cats' spinal motoneurones. Brain Res. 54, 376-380.
48. Potashner S. J. (1979) Baclofen inhibits aspartate and glutamate release from slices. J. Neurochem. 32, 103-109.
49. Potier B. and Dutar P. (1993) Presynaptic inhibitory effect of baclofen on hippocampal inhibitory synaptic transmission involves a pertussis toxin-sensitive G-protein. Eur. J. Pharmacol. 231, 427-433.
50. B receptor subtypes modulate neurotransmitter release in the rat brain cortex. Adv. Biochem. Psychopharmacol. 47, 205-216.
51. Rink T. J., Montecucco C., Hesketh T. R., and Tsien R. Y. (1980) Lymphocyte membrane potential assessed with fluorescent probes. Biochim. Biophys. Acta 595, 15-30.
52. B agonists modulate a transient potassium current in cultured mammalian hippocampal neurons. Neurosci. Lett. 118, 9-13.
53. Sanchez-Prieto J., Budd D. C., Herrero I., Vazquez E., and Nicholls D. G. (1996) Presynaptic receptors and the control of glutamate exocytosis. Trends Neurosci. 19, 235-239.
54. Scanziani M., Capogna M., Gähwiler B. H., and Thompson S. M. (1992) Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus. Neuron 9, 919-927.
55. 2+ channels involved? Neuropharmacology 34, 1549-1557.
56. B receptor-mediated inhibition of Ca2+ currents and synaptic transmission in cultured rat hippocampal neurones. J. Physiol. (Lond.) 444, 669-686.
57. Sihra T. (1997) Protein phosphorylation and dephosphorylation in isolated nerve terminals (synaptosomes), in Regulatory Protein Modification: Techniques and Protocols (Hemmings H. C. Jr., ed), pp. 67-119. Humana Press, Totowa, New Jersey.
58. Sihra T. S. and Nichols R. A. (1993) Mechanisms in the regulation of neurotransmitter release from brain nerve terminals: current hypotheses. Neurochem. Res. 18, 47-58.
59. 2+ channels. J. Neurochem. 61, 1220-1230.
60. Stephenson F. A. (1988) Understanding the GABA-A receptor: a chemically gated ion channel. Biochem. J. 249, 21-32.
61. B receptor agonists and antagonists on potassium-stimulated [Ca2+]i in rat brain synaptosomes. Neuropharmacology 28, 699-704.
62. B receptor-mediated inhibition of the vesicular release of noradrenaline and acetylcholine. J. Neurochem. 58, 1239-1245.
63. B-receptor-mediated inhibition of calcium signals in isolated nerve terminals. Neurochem. Int. 24, 349-361.
64. Thompson S. M. and Gahwiler B. H. (1992) Comparison of the actions of baclofen at pre- and postsynaptic receptors in the rat hippocampus in vitro. J. Physiol. (Lond.). 451, 329-345.
65. 2+ and glutamate release. J. Neurochem. 53, 1693-1699.
66. Travagli R. A., Ulivi M., and Wojcik W. J. (1991) gamma-Aminobutyric acid-B receptors inhibit glutamate release from cerebellar granule cells: consequences of inhibiting cyclic AMP formation and calcium influx. J. Pharmacol. Exp. Ther. 258, 903-909.
67. Wojcik W. J., Travagli R. A., Costa E., and Bertolino M. (1990) Baclofen inhibits with high affinity an L-type-like voltage-dependent calcium channel in cerebellar granule cell cultures. Neuropharmacology 29, 969-972.
68. 2+ influx. J. Physiol. (Lond.). 485, 649-657.
69. Wu L. and Saggau P. (1997) Presynaptic inhibition of elicited neurotransmitter release. Trends Neurosci. 20, 204-212.