Exercise reduces epicardial coronary artery wall stiffness: Roles of cGMP and cAMP

Medicine and Science in Sports and Exercise

Volumn 30, Issue 2, 1998, Pages 220-228

  Stewart, Julian M ^a   Xu, Xiaobin ^a   Ochoa, Manuel ^a   Hintze, Thomas H ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

E(inc); Nitric oxide; Vasodilation

Indexed keywords

ACETYLCHOLINE; ADENOSINE; CYCLIC AMP; CYCLIC GMP; GLYCERYL TRINITRATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTERY DIAMETER; ARTERY WALL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY CIRCUMFLEX BRANCH; CORONARY ARTERY DILATATION; DOG; EXERCISE; HEART INFARCTION; NONHUMAN; PATHOPHYSIOLOGY;

ACETYLCHOLINE; ADENOSINE; ANALYSIS OF VARIANCE; ANIMALS; BLOOD PRESSURE; CORONARY VESSELS; CYCLIC AMP; CYCLIC GMP; DOGS; ELASTICITY; NITROGLYCERIN; PHYSICAL CONDITIONING, ANIMAL; REGRESSION ANALYSIS; VASODILATOR AGENTS;

EID: 0031929598     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005768-199802000-00008     Document Type: Article

References (34)

1. ARMENTARO, R. L., J. LEVENSON, J. G. BARRA, et al. Assessment of elastin and collagen contribution to aortic elasticity in conscious dogs. Am. J. Physiol. Heart Circ. Physiol. 260(Suppl. 29):H1870-H1877, 1991.
2. ARMENTARO, R. L., J. G. BARRA, J. LEVENSON, A. SIMON, and R. H. PICHEL. Arterial wall mechanics in conscious dogs. Assessment of viscous, inertial, and elastic moduli to characterize aortic wall behavior. Circ. Res. 76:468-478, 1995.
3. BANK, A. J., R. F. WILSON, S. H. KUBO, J. E. HOLTE, T. J. DRESING, and H. WANG. Direct effects of smooth muscle relaxation and contraction on in vivo human brachial artery elastic properties. Circ. Res. 77:1008-1016, 1995.
4. BARRA, J. G., R. L. ARMENTARO, J. LEVENSON, E. I. C. FISCHER, R. H. PICHEL, and A. SIMON. Assessment of smooth muscle contribution to descending thoracic aortic elastic mechanics in conscious dogs. Circ. Res. 73:1040-1050, 1993.
5. BERDEAUX, A., C. L. ROCHELLE, V. RICHARD, and J. F. GIUDICELLI. Opposed responses of large and small coronary arteries to propranolol during exercise in the dog. Am. J. Physiol. 262:H1579-H1584, 1992.
6. BERGEL, D. H. The static elastic properties of the arterial wall. J. Physiol. 156:445-457, 1960.
7. BURTON, A. C. Relation of structure to function of the tissues of the wall of blood vessels. Physiol. Rev. 34:619-642, 1954.
8. CANTY, J. M.,JR., and J. S. SCHWARTZ. Nitric oxide mediates flow-dependent epicardial coronary vasodilation to changes in pulse frequency but not mean flow in conscious dogs. Circulation 89:375-384, 1994.
9. CURRENS, J. H. and P. D. WHITE. Half century of running:clinical, physiologic and autopsy findings in the case of Clarence De Mar "Mr. Marathoner." N. Engl. J. Med. 265:988-993, 1961.
10. GOW, B. S. Circulatory correlates:vascular impedance, resistance, and capacity. In:Handbook of Physiology. Ser. 2, Sect. 2:The Cardiovascular System. D. F. Bohr, A. P. Somlyo, H. V. Sparks Jr. (Eds.). Vol 2:Vascular smooth muscle. Bethesda:The American Physiological Society, 1980, pp. 353-408.
11. HASKELL, W. L., C. SIMS, J. MYLL, W. M. BORTZ, F. G. ST. GOAR, and E. L. ALDERMAN. Coronary size and dilating capacity in ultra distance runners. Circulation 87:1076-1082, 1993.
12. HINTZE, T. H., and S. F. VATNER. Reactive dilation of large coronary arteries in conscious dogs. Circ. Res. 54:50-57, 1984.
13. HUTCHESON, I. R. and T. M. GRIFFITH. Release of endothelium-derived relaxing factor is modulate by both frequency and amplitude of pulsatile flow. Am. J. Physiol. 261:H257-H262, 1991.
14. LAUGHLIN, M. H. Effects of exercise training on coronary vascular capacity. J. Appl. Physiol. 58:4368-476, 1985.
15. LAUGHLIN, M. H., K. A. OVERHOLSER, and M. BHATTE. Exercise training increases coronary transport reserve in miniature swine. J. Appl. Physiol. 67:1140-1149, 1989.
16. LAUGHLIN, M. H., and R. M. MCALLISTER. Exercise training-induced coronary vascular adaptation. J. Appl. Physiol. 73(6):2209-2225, 1992.
17. LEVINE, B. D. and J. H. MITCHELL. "Ultra" coronary arteries:bigger and better? Circulation 87:1402-1404, 1993.
18. MANN, G. V., A. SPOERRY, M. GRAY, and D. JARASHOW. Atherosclerosis in the Masai. Am. J. Epidemiol. 95:26-37, 1972.
19. MORRIS, J. N. and M. D. CRAWFORD. Coronary artery disease and physical activity of work:evidence of a national necropsy study. Br. Med. J. 5111:1485-1496, 1958.
20. PAGANI, M., I. MIRSKY, H. BAIG, W. M. MANDERS, P. KERKOFF, and S. F. VATNER. Effects of age on aortic pressure-diameter and elastic stiffness-stress relationships in unanesthetized sheep. Circ. Res. 44:420-429, 1979.
21. PAGANI, M., A. PASIPOULARIDES, and S. F. VATNER. Elastic properties of coronary arteries in conscious dogs. Adv. Physiol. Sci. 8:262-270, 1981.
22. RUBANYI, G. M., J. C. ROMERO, and P. M. VANHOUTTE. Flow-induced release of endothelium-derived relaxing factor. Am. J. Physiol. 250:H1145-H1149, 1986.
23. SCHEUER, J. and C. M. TIPTON. Cardiovascular adaptations to physical training. Annu. Rev. Physiol. 39:221-251, 1977.
24. SCHWARTZ, J. S., K. W. BARAN, and R. J. BACHE. Effect of stenosis on exercise induced dilation of large coronary arteries. Am. Heart J. 119:520-524, 1990.
25. SESSA, W. C., K. PRITCHARD, N. SEYEDI, J. WANG, and T. H. HINTZE. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ. Res. 74:349-353, 1994.
26. SHEN, W., J. WANG, M. OCHOA, X. XU, and T. H. HINTZE. Role of endothelium-derived relaxing factor in parasympathetic coronary vasodilation following carotid chemoreflex activation in conscious dogs. Am. J. Physiol. 267:H605-H613, 1994.
27. SHEN, W., X. XU, M. OCHOA, M. S. WOLIN, and T. H. HINTZE. Role of nitric oxide in the regulation of oxygen consumption in conscious dogs. Circ. Res. 75:1086-1095, 1994.
28. STEWART, J. M., J. WANG, and T. H. HINTZE. Role of EDRF in the regulation of shear rate in large coronary arteries in conscious dogs. J. Mol. Cell. Cardiol. 26:1625-1633, 1994.
29. STONE, H. L. Coronary flow, myocardial oxygen consumption, and exercise training in dogs. J. Appl. Physiol. 49:759-768, 1980.
30. TESTFAMARIAM B., R. M. WEISBROD, and R. A. COHEN. Endothelium inhibits responses of rabbit carotid artery to adrenergic stimulation. Am. J. Physiol. 253:H792-H798, 1987.
31. VATNER, S. F., M. PAGANI, W. T. MANDERS, and A. PASIPOULARIDES. Alpha-adrenergic vasoconstriction and nitroglycerin vasodilation of large coronary arteries in the conscious dog. J. Clin. Invest. 65:5-14, 1980.
32. WANG, J., M. S. WOLIN, and T. H. HINTZE. Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs. Circ. Res. 73:829-838, 1993.
33. WYATT, H. L. and J. MITCHELL. Influences of physical conditioning and deconditioning on coronary vasculature of dogs. J. Appl. Physiol. 45:619-625, 1978.
34. ZHAO, G., X. XU, M. OCHOA, and T. H. HINTZE. Exercise enhances reflex cardiac cholinergic-NO mediated coronary vasodilation in conscious dogs. Circulation 92:I-767, 1995.