Intratumour injection of immunoglobulins labelled with the α-particle emitter 211At: Analyses of tumour retention, microdistribution and growth delay

British Journal of Cancer

Volumn 77, Issue 7, 1998, Pages 1115-1122

  Larsen, R H ^a,b   Bruland, O S ^c  

^a UNIVERSITY OF OSLO   (Norway)

^b DUKE UNIVERSITY   (United States)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Antibodies; Intratumour injection; particle irradiation

Indexed keywords

ASTATINE 211; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY TP3; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ALPHA RADIATION; ANIMAL TISSUE; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; AUTORADIOGRAPHY; CANCER INHIBITION; CANCER RADIOTHERAPY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG RETENTION; DRUG TUMOR LEVEL; HUMAN TISSUE; INTRATUMORAL DRUG ADMINISTRATION; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION; RADIOIMMUNOTHERAPY; TUMOR GROWTH; TUMOR VOLUME; XENOGRAFT;

ANIMALS; ASTATINE; AUTORADIOGRAPHY; HUMANS; IMMUNOGLOBULINS; INJECTIONS, INTRALESIONAL; MICE; MICE, NUDE; OSTEOSARCOMA; RADIOIMMUNOTHERAPY; SUBRENAL CAPSULE ASSAY;

EID: 0031929068     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.185     Document Type: Article

References (41)

1. Brown I (1986) Astatine-211: its application in cancer therapy. Appl Radiat Isot 37: 789-798
2. Bruland ØS, Fodstad Ø, Funderud S and Pihl A (1986) New monoclonal antibodies specific for human sarcomas. Int J Cancer 37: 27-31
3. Bruland ØS, Fodstad Ø and Pihl A (1987) Selective localization of two radiolabelled anti-sarcoma monoclonal antibodies in human osteosarcoma xenografts. Br J Cancer 56: 21-25
4. Bruland ØS, Fodstad Ø, Stenwig A and Pihl A (1988) Expression of a novel human osteosarcoma associated cell surface antigen. Cancer Res 48: 5302-5309
5. 153Sm-EDTMP. Acta Oncol 35: 381-384
6. Cobb LM, Harrison A and Butler SA (1988) Toxicity of astatine-211 in the mouse. Human Toxicol 7: 529-534
7. Delgado C, Pedley C, Herraez A, Boden R, Boden JA, Keep PA, Chester KA, Fisher D, Begent RHJ and Francis GE (1996) Enhanced tumour specificity of an anti-carcinoembryonic antigen Fab′ fragment by poly(ethylene glycol) (PEG) modification. Br J Cancer 73: 175-182
8. 125I]iodobenzoyl conjugate. Bioconjug Chem 2: 171-179
9. Hall EJ (1994) Radiobiology for the Radiologist. 4th edn. JB Lippincott: Philadelphia
10. 211At-IgG conjugate which is stable in vivo. Int J Appl Radiat Isot 35: 1005-1008
11. Harrison A and Royle L (1987) Efficacy of astatine-211 labelled monoclonal antibody in treatment of murine T-cell lymphoma. NCI Monogr 3: 157-158
12. Humm JL (1987) A microdosimetric model of astatine-211 labelled antibodies for radioimmunotherapy. Int J Radiat Oncol Biol Phys 13: 1767-1773
13. Huneke RB, Pippin CG, Squire RA, Brechbiel MW, Ganzow OA and Strand M (1992) Effective α-particle-mediated radioimmunotherapy of murine leukemia. Cancer Res 52: 5818-5820.
14. 207Bi. Phys Rev 11: 1385-1391
15. Kassis AI, Harris CR, Adelstein SJ, Ruth TJ, Lambrecht R and Wolf AP (1986). The in vitro radiobiology of astatine-211 decay. Radiat Res 105: 27-36
16. Kozak RW, Atcher RW, Ganzow OA, Friedman AM, Hines J and Waldman TA (1986) Bismuth-212-labelled anti-Tac monoclonal antibody: α-particle-emitting radionuclide as modalities for radioimmunotherapy. Proc Natl Acad Sci USA 83: 474-478
17. Larsen RH and Bruland ØS (1995) Radiolysis of radioimmunoconjugates. Reduction in antigen binding ability by α-particle radiation. J Labelled Compound Radiopharmaceut 36: 1009-1018
18. 211At-labelling of polymer-particles for radiotherapy: synthesis, purification and stability. J Labelled Compound Radiopharmaceut 33: 977-986
19. 125I-labelled monoclonal antibodies. Biodistribution in mice carrying human osteosarcoma xenografls. J Labelled Compound Radiopharmaceut 34: 773-785
20. 211At-TP-3 monoclonal antibody: Comparison with astatine-211-labelled bovine serum albumin, free astatine-211 and external beam X-rays. Radiat Res 139: 178-184
21. 211At-labelled monoclonal antibody. Br J Cancer 69: 1000-1005
22. 211At in a murine intraperitoneal tumour model. Gynecol Oncol 57: 9-14
23. 211 At reaction. Appl Radiat Isot 47: 135-143
24. 211At-methylene blue for targeted radiotherapy of human melanoma xenografts. Cancer Res 52: 4385-4390
25. Loevinger R, Budinger TF and Watson EE (1991) MIRD Primer for Absorbed Dose Calculation (revised edition). The Society of Nuclear Medicine: New York
26. Maclis RM, Kaplan WD, Ferrera, JLM, Archer RW, Hines JJ, Burakoff SJ and Coleman CN (1989) Resident Essay Award: alpha particle radioimmunotherapy: animal models and clinical prospects. Int J Radiat Oncol Biol Phys 16: 1377-1387
27. Paus E and Nustad K (1989) Immunoradiometric assay for αγ- and γγ-enolase (neuron-specific enolase), with use of monoclonal antibodies and magnetizable particles. Clin Chem 35: 2034-2038
28. Remington RD and Schork MA (1985) Statistics with Applications to the Biological and Health Sciences, 2nd edn. Prentice-Hall: Englewood Cliffs, New Jersey
29. Riva P, Arista A, Vittorio T, Sturiale C, Franchesci G, Spinelli A, Riva N, Casi M, Moscatelli G and Frattarelli M (1994) Intralesional radioimmunotherapy of malignant gliomas. Cancer 73: 1076-1082
30. Roeske JC and Chen TY (1993) Dosimetry of administered radiolabelled antibodies. Med Phys 20: 593-600
31. Rowlinson-Busza G, Bamias A, Krausz T and Epenetos AA (1991) Uptake and distribution of specific and control monoclonal antibodies in subcutaneous xenografts following intratumor injection. Cancer Res 51: 3251-3256
32. Royal Society/Universities Federation for Animal Welfare (UFAW) (1987) Guidelines on the care of laboratory animals and their use for scientific purposes 1. Housing and care. UFAW: London
33. Sgouros G (1995) Radioimmunotherapy of micrometastases: sidestepping the solid-tumor hurdle (editorial). J Nucl Med 36: 1910-1912
34. United Kingdom Coordinating Committee on Cancer Research (UKCCCR) (1988) UKCCCR guidelines for the welfare of animals in experimental neoplasia. Br J Cancer 58: 156-160
35. 211At]astatodeoxyuridine, an α-particle emitting endoradiotherapeutic agent undergoing DNA incorporation. Cancer Res 56: 1204-1209
36. 211At-labeled concavalin A bound to cell membranes. J Radioanal Chem 64: 33-39
37. 90Y) colloids in mice. Gynecol Oncol 47: 358-365
38. Weber DA, Eckereman KF, Dillman LT and Ryman JC (1989) MIRD: Radionuclide Data and Decay Schemes. The Society of Nuclear Medicine: New York
39. Wheldon TE and O'Donnoghue JA (1990) The radiobiology of targeted radiotherapy. Int J Radiat Biol 58: 1-21
40. Yuan J (1993) Estimation of variance for AUC in animal studies. J Pharm Sci 82: 761-763
41. 2 fragments with the α-particle-emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity. Proc Natl Acad Sci USA 86: 7149-7153