Multicenter trial comparing tramadol and morphine for pain after abdominal surgery

Drugs under Experimental and Clinical Research

Volumn 24, Issue 1, 1998, Pages 9-16

  Gritti, G ^a   Verri, M ^a   Launo, C ^b   Palermo, S ^b   Novelli, G P ^c   Casali, R ^c   Paoletti, F ^d   Boanelli, A ^d   Tufano, R ^e   Leone, D ^e  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c Policlinico Careggi   (Italy)

^d POLICLINICO MONTELUCE   (Italy)

^e Azienda Universitaria Policlinico   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; DICLOFENAC; MORPHINE; TRAMADOL; UNCLASSIFIED DRUG;

ABDOMINAL SURGERY; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PAIN ASSESSMENT; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; SLEEP;

ABDOMINAL PAIN; ADULT; AGED; AGED, 80 AND OVER; ANALGESICS, OPIOID; ANALYSIS OF VARIANCE; CHI-SQUARE DISTRIBUTION; FEMALE; HUMANS; INJECTIONS, INTRAMUSCULAR; INTESTINE, LARGE; MALE; MIDDLE AGED; MORPHINE; PAIN, POSTOPERATIVE; TRAMADOL;

EID: 0031928901     PISSN: 03786501     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Davies P., Ogg T. Postoperative pain relief. Practitioner, 236, 840, 1992.
2. Benedetti C. Acute pain: a review of its effects and therapy with systemic opioids. In: C. Benedetti et al. (Eds.). "Advances in Pain Research and Therapy". Raven Press Ltd, New York, 1990, pp. 367-424.
3. Raffa R.B., Najak R.K., Liao S., Minn F.L. The mechanism(s) of action and pharmacokinetics of tramadol hydrochloride. Rev. Contemp. Pharmacother., 6, 485, 1995.
4. Raffa R.B., Friderichs E., Reimann W., Shank R.P., Codd E.E., Vaught J.L. Opioid and non-opioid components independently contribute to the mechanism of action of tramadol, an "atypical" opioidanalgesic. J. Pharm. Exp. Ther., 260, 275, 1992.
5. Driessen B., Schultz H., Reimann W. Evidence for a non-opioid component in the analgesic action of tramadol. Naunyn -Schmiedebergs Arch. Pharmacol., 341, R 104, 1990.
6. Driessen B., Reimann W. Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro. Br. J. Pharmacol., 105, 147, 1992.
7. Desmeules J.A., Piguet V., Collart L., Dayer P. Contribution of monoaminergic modulation to the analgesic effect of tramadol. Br. J. Clin. Pharmacol., 41, 7, 1996.
8. Osipova N.A., Novikov G.A., Beresnev V.A., Loseva N.A. Analgesic effect of tramadol in cancer patients with chronic pain: a comparison with prolonged-action morphine sulfate. Curr. Ther. Res., 50(6), 812, 1991.
9. Rodríguez N., Rodríguez Pereira E. Tramadol in cancer pain. Curr. Ther. Res., 50, 1142, 1989.
10. Tawfik M.O., Elborolossy K., Nasr F. Tramadol hydrochloride in the relief of cancer pain. A double-blind comparison against sustained release morphine. Pain, (Suppl. 5), 377, 1990.
11. Grond S., Zech D., Lynch J., Schug S., Lehmann K.A. Tramadol - a weak opioid for relief of cancer pain. Pain Clinic, 5(4), 241, 1992.
12. Wilder-Smith C.H., Schimke J., Osterwalder B., Senn H.J. Oral tramadol, a m-opioid agonist and monoamine reuptake-blocker, and morphine for strong cancer-related pain. Ann. Oncol., 5, 141, 1994.
13. Bernatsky G., Iurna I. Intrathecal injection of codeine, buprenorphine, tilidine, tramadol, nephopam depresses the tail-flick responses in rats. Eur. J. Pharmacol., 120, 75, 1986.
14. Houmes R.M., Voels M.A., Verkaaik A., Erdmann W., Lachmann B. Efficacy and safety of tramadol versus morphine for moderate and severe postoperative pain, with special regard to respiratory depression. Anesth. Analg., 74, 510, 1992.
15. Vickers M.D., O'Flaherty D., Szekely S.H., Read M., Yoshizumi J. Tramadol: pain relief by an opioid without depression of respiration. Anaesthesia, 47, 291, 1992.
16. Cossman M., Kohnen C. General tolerability and adverse event profile of tramadol hydrochloride. Rev. Contemp. Pharmacother., 6, 513, 1995.
17. Richter W., Barth H., Flohe L., Giertz H. Clinical investigation on the development of dependence during oral therapy with tramadol. Arzneim. Forsch./Drug Res., 35(2), 1742, 1985.
18. Vickers M.D., Paravicini D. Comparison of tramadol with morphine for postoperative pain following abdominal surgery. Eur. J. Anesth., 12, 265, 1995.
19. Occhioni R., Picaro M., Principi F., et al. Tramadolo, dolore post-operatorio in chirurgia toracica. Minerva Anestesiol., 62 (Suppl. 1 No. 10), 14, 1996.
20. Bontate G., Gulotta G., Mularo A., Palmeri M., Sparacia B., Sansone A. Controllo del dolore postoperatorio da taglio cesareo mediante infusione continua di tramadolo. Confronto con ketorolac trometamina. Minerva Anestesiol., 62 (Suppl. 1 No. 10), 16, 1996.
21. Cesareo E., Pinto M., Prato R., et al. Analgesia postoperatoria in chirurgia ginecologica ed urologica maggiore con un nuovo analgesico centrale: il tramadolo. Minerva Anestesiol., 62 (Suppl. 1 No. 10), 15, 1996.
22. Bellinvia C., Musitano A., Grasso L., Caminiti G. L'analgesia postoperatoria con infusione continua di tramadolo in chirurgia videolaparoscopica. Minerva Anestesiol., 62 (Suppl. 1 No. 10), 27, 1996.
23. Di Angelo P., Bosco M., Forastière E.M.A., Evangelista M., Borgonuovo P., Tessitore L. Tramadolo e analgesica postoperatoria: infusione continua. In: "Tramadolo Dolore Acuto e Cronico". A.F. Sabato, Rome, 8 Feb. 1997, pp. 85-99.