Construction of single-chain Fv fragments of anti-MIR monoclonal antibodies

Annals of the New York Academy of Sciences

Volumn 841, Issue , 1998, Pages 475-477

  Tzartos, S J ^a   Tsantili, P ^a   Papanastasiou, D ^a   Mamalaki, A ^a  

^a HELLENIC PASTEUR INSTITUTE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR ANTIBODY; IMMUNOGLOBULIN FRAGMENT; MONOCLONAL ANTIBODY; RECEPTOR SUBUNIT;

CONFERENCE PAPER; GENETIC ENGINEERING; MYASTHENIA; RECEPTOR AFFINITY; RECEPTOR BINDING; SERUM; SITE DIRECTED MUTAGENESIS;

EID: 0031928675     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb10966.x     Document Type: Conference Paper

References (5)

1. MAMALAKI, A. & S. J. TZARTOS. 1994. Nicotinic acetylcholine receptor: structure, function, and main immunogenic region. Adv. Neuroimmunol. 4: 339-354.
2. SOPHIANOS, D. & S. J. TZARTOS. 1989. Fab fragments of monoclonal antibodies protect the human acetylcholine receptor against antigenic modulation caused by myasthenic sera. J. Autoimmun. 2: 777-789.
3. MAMALAKI, A., N. TRAKAS & S. J. TZARTOS. 1993. Bacterial expression of a single-chain Fv fragment which efficiently protects the acetylcholine receptor against antigenic modulation caused by myasthenic antibodies. Eur. J. Immunol. 23: 1839-1845.
4. TZARTOS, S., L. LANGEBERG, S. HOCHSCHWENDER & J. LINDSTROM. 1983. Demonstration of a main immunogenic region on acetylcholine receptors from human muscle using monoclonal antibodies to human receptor. FEBS Lett. 158: 116-118.
5. MANUAL, C., B. D. KINGERY, J. M. ANCHIN, S. SUBRAMANIAM & D. S. LINTHICUM. 1996. ABGEN: a knowledge based automated approach for antibody structure modeling. Nat. Biotechnol. 14: 323-328.