Altered levels of urokinase on monocytes and in serum of children with AIDS; effects on lymphocyte activation and surface marker expression

Journal of Leukocyte Biology

Volumn 64, Issue 2, 1998, Pages 198-202

  Murali, Rama ^b   Wolfe, Joshua H ^b   Erber, Rebecca ^b   Chice, Seto M ^b   Murali, M R ^b   Durkin, Helen G ^b   Zach, Petr ^b   Auci, Dominick L ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b NONE

Author keywords

CD19; CD3; Plasminogen activator

Indexed keywords

LYMPHOCYTE SURFACE MARKER; PLASMINOGEN ACTIVATOR; SERINE PROTEINASE; UROKINASE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CELL CYCLE; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; DATA ANALYSIS; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; MALE; MICROFLUOROMETRY; PATHOGENESIS; PRIORITY JOURNAL;

TRIXIS;

EID: 0031928021     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.64.2.198     Document Type: Article

References (23)

1. Jones, C. M., Goldfarb, R. H., Holden, H. T. (1983) Macrophage cell lines behave as activated macrophages in production and regulation of plasminogen activators. Cancer Invest. 3, 207-213.
2. Vassalli, J. U., Dayer, J. M., Wohlwend, A., Belin, D. (1984) Concomitant secretion of prourokinase and of plasminogen activator specific inhibitor by cultured human monocytes-macrophages. J. Exp. Med. 159, 1653-1688.
3. Golden, J. P., Stephens, R. W. (1983) Minactivin: a human monocyte product which specifically inactivates urokinase-type plasminogen activator. Eur. J. Biochem. 136, 517-520.
4. Stephens, R. W., Golden, J. P., Fayle, D. R. H. (1985) Minactivin expression in human monucyte and macrophage cell populations. Blood 66, 333-337.
5. Erickson, L. A., Schleef, T. N., Loskutoff, D. J. (1985) The fibrinolytic system of the vascular wall. Clin Haemalol. 14, 513-530.
6. Ziegeler, K., Unanue, F. R. (1981) Identification of a macrophage antigen processing event required for la restricted antigen presentation to T lymphocytes. J Immunol. 127, 1869-1873.
7. Nykjaer, A., Moller, B., Todd, R. F., Tove, C., Anderasen, P., Gliemann, J., Petersen, C. M. (1994) Urokinase receptor: An activation antigen in human T lymphocytes. J. Immunol. 152, 505-516.
8. Cohen, S. D., Israel, E., Meier, B. (1981) Plasminogen activator is an apparent lymphocyte mitogen. J. Immunol. 126, 1415-1419.
9. Gladstone, J., Spooner, C. (1987) The role of plasminogen activator in regulating gamma interferon production by T lymphocytes. 18th International Leukocyte Culture Conference, La Grande, Motte, Abstract A.15.
10. Goldfarb, R. H., Timonen, T., Herberman, R. (1984) Production of plasminogen activator by human natural killer cells. J. Exp. Med. 159, 935-951.
11. Kerr, J. F. R., Wyllie, A. H., Curie, A. R. (1972) Apoptosis: A basic biological phenomenon with wide ranging implications in tissue kinetics. Br. J. Cancer 26, 239.
12. Weiss, A. Imboden, K., Hardy B. (1984) The role of T3/antigen receptor complexes in T cell activation. Annu. Rev. Immunol. 4, 593-599.
13. Lepe-Zuniga, J. C., Mansell, P. W., Hersh, E. M. (1987) Idiopathic production of interleukin-1 in the acquired immunodeficiency syndrome. J. Clin. Microbiol. 25, 1695-1700.
14. Ascher, M. S., Haynes, W. (1990) AIDS as immune system activation. II. The panergic imnesia hypothesis. J. Acquir. Immune Defic. Syndr. 3, 177-191.
15. Reddy, M. M., Sorrell, S. J., Lange, M., Grieco, M. H. (1988) Tumor necrosis factor and HIV p24 antigen levels in serum of HIV infected populations. J. Acquir. Immune Defic. Syndr. 1, 436-440.
16. + drug abusers with persistent generalized lymphadenopathy: histology, immunohistochemistry and pathogenetic correlations. Prog. AIDS Pathol. 2, 33-50.
17. U. S. Centers for Disease Control (1988) Revision of the CDC Surveillance Case Definition for Acquired Immunodeficiency Syndrome. CDC Publ. AIDS 2, 119-123.
18. Manchanda, N., Schwartz, B. S. (1990) LPS induced modulation of human monocyte urokinase production and activity. J. Immunol. 145, 4174-4180.
19. Koh, S. C., Yuen, R., Viegas, O. A., Chua, S. E., Sen D. K., Ratnam, S. S. (1991) Plasminogen activators t-PA and u-PA and its inhibitor (PAI) in normal males and females. Thromb. Haemostas. 66, 581-585.
20. Auci, D. L., Durkin, H. G., Murali, M. R. (1992) Dysregulated proteolysis in AIDS. Immunol. Invest. 21, 305-319.
21. Auci, D. L., Durkin, H. G., Murali, M. R. (1992) Constitutive production of PAI-II and increased expression of GM1 ganglioside by peripheral blood monocytes from patients with AIDS. Evidence of monocyte activation in vivo. J. Leukoc. Biol. 52, 282-286.
22. Clerici, M., Shearer, G. M. (1993) A Th1-Th2 switch is a critical step in the etiology of HIV infection. Immunol. Today 14, 107-111.
23. Ku, G. S., Quigley, J. P., Sultzer, B. M. (1981) Time dependent inhibition of tuberculin-induced lymphocyte DNA synthesis by a serine protease inhibitor. J. Immunol. 126, 2209-2214.