Nicotinic receptors and calcium channels in small cell lung carcinoma: Functional role, modulation, and autoimmunity

Annals of the New York Academy of Sciences

Volumn 841, Issue , 1998, Pages 606-624

  Sher, E ^a,d   Codignola, A ^a   Passafaro, M ^a,b   Tarroni, P ^a   Magnelli, V ^c   Carbone, E ^c   Clementi, F ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Institute of Biotechnologies Applied to Pharmacology   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; HORMONE; NERVE GROWTH FACTOR; NICOTINIC RECEPTOR; OPIATE;

AUTOIMMUNITY; CELL PROLIFERATION; CONFERENCE PAPER; EATON LAMBERT SYNDROME; HORMONE RELEASE; HUMAN; HUMAN CELL; INSULINOMA; LUNG SMALL CELL CANCER;

EID: 0031927287     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb10993.x     Document Type: Article

References (62)

1. CATTANEO, M. G., A. CODIGNOLA, L. M. VICENTINI, F. CLEMENTI & E. SUER. 1993. Nicotine stimulates a serotonergic autocrine loop in human small cell lung carcinoma. Cancer Res. 53: 5566-5568.
2. CODIGNOLA, A., P. TARRONI, M. G. CATTANEO, L. M. VICENTINI, F. CLEMENTI & SHER. 1994. Serotonin release and cell proliferation are under the control of α-bungarotoxin-sensitive nicotinic receptors in small cell lung carcinoma cell lines. FEBS Lett. 342: 286-290.
3. CUNNINGHAM, J. M., V. A. LENNON, E. H. LAMBERT & B. SCHEITHAUER. 1985. Acetylcholine receptors in small cell lung carcinomas. J. Neurochem. 45: 159-167.
4. 5 nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines. Proc. Natl. Acad. Sci. U.S.A. 89: 1572-1576.
5. TARRONI, P., F. RUBBOLI, B. CHINI, R. ZWART, M. OORTGIESEN, E. SHER & F. CLEMENTI. 1992. Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines. FEBS Lett. 312: 66-70.
6. MANECKJEE, R. & J. D. MINNA. 1990. Opioid and nicotine receptors affect growth regulation of human small-cell lung cancer. Proc. Natl. Acad. Sci. U.S.A. 87: 3294-3298.
7. QUIK, M., J. CHAN & J. PATRICK. 1994. Alpha-bungarotoxin blocks the nicotinic receptor mediated increase in cell number in a neuroendocrine cell line. Brain Res. 665: 161-167.
8. GRAY, R., A. S. RAJAN, K. A. RADCLIFFE, M. YAKEHIRO & J. A. DANI. 1996. Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature 383: 713-716.
9. RATHOUZ, M. M., S. VIJAYARAGHAVAN & D. K. BERG. 1996. Elevation of intracellular calcium levels in neurons by nicotinic acetylcholine receptors. Mol. Neurobiol. 12: 117-131.
10. CODIGNOLA, A., J. M. MCINTOSH, M. G. CATTANEO, L. M. VICENTINI, F. CLEMENTI & E. SHER. 1996. α-Conotoxin Imperialis I inhibits nicotine-evoked hormone release and cell proliferation in human neuroendocrine carcinoma cells. Neurosci. Lett. 206: 53-56.
11. MCINTOSH, J. M., D. YOSHIKAMI, E. MAHE, D. B. NIELSEN, J. D. RIVIER & B. M. OLIVERA. 1994. A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImI. J. Biol. Chem. 269: 16733-16739.
12. 9 receptors. Mol. Pharmacol. 48: 194-199.
13. MCCANN, F. V., O. S. PETTENGILL, J. J. COLE, J. A. G. RUSSEL & G. D. SORENSON. 1981. Calcium spike electrogenesis and other electrical activity in continuously cultured small cell carcinoma of the lung. Science 212: 1155-1157.
14. MCCANN, F. V., J. J. COLE, O. S. PETTENGILL, J. A. G. RUSSEL & G. D. SORENSON. 1985. In The Electrophysiology of the Secretory Cell, p. 241-266. Elsevier. Amsterdam/New York.
15. 2+ flux in a human small cell carcinoma line. Nature 317: 737-739.
16. DE AIZPURUA, H. J., E. H. LAMBERT, G. E. GRIESMANN, B. M. OLIVERA & V. A. LENNON. 1988. Antagonism of voltage-gated calcium channels in small cell carcinoma of patients with and without Lambert-Eaton syndrome by autoantibodies ω-conotoxin and adenosine. Cancer Res. 48: 4719-4724.
17. SHER, E., A. PANDIELLA & F. CLEMENTI. 1990. ω-Conotoxin-sensitive voltage-operated calcium channels in small-cell lung carcinoma cell lines: pharmacological, functional, and immunological properties. Cancer Res. 50: 3892-3896.
18. PANCRAZIO, J. J., H. K. OIE & Y. I. KIM. 1989. Voltage-dependent ion channels in small cell lung cancer cell lines. Cancer Res. 49: 5901-5906.
19. CODIGNOLA, A., P. TARRONI, F. CLEMENTI, A. POLLO, M. LOVALLO, E. CARBONE & E. SHER. 1993. Calcium channel subtypes controlling serotonin release from human small cell lung carcinoma cell lines. J. Biol. Chem. 268: 26240-26247.
20. VIGLIONE, M. P., T. J. O'SHAUGHNESSY & Y. I. KIM. 1995. Inhibition of calcium currents and exocytosis by Lambert-Eaton syndrome antibodies in human lung cancer cells. J. Physiol. 488: 303-317.
21. BARRY, E. L. R., M. P. VIGLIONE, Y. I. KIM & S. C. FROEHNER. 1995. Expression and antibody inhibition of P-type calcium channels in human small cell lung carcinoma cells. J. Neurosci. 15: 274-283.
22. 2+-dependent secretion in human small-cell lung carcinoma cells. J. Neurosci. 16: 3672-3684.
23. MERINEY, S. D., S. C. HULSIZER, V. A. LENNON & A. D. GRINNEL. 1996. Lambert-Eaton myasthenic syndrome immunoglobulins react with multiple types of calcium channels in small-cell lung carcinoma. Ann. Neurol. 40: 739-749.
24. LENNON, V. A., T. J. KRYZER, G. E. GRIESMANN, P. E. O'SUILLEABHAIN, A. J. WINDEBANK, A. WOPPMANN, G. P. MILJANICH & E. H. LAMBERT. 1995. Calcium-channel antibodies in the Lambert-Eaton syndrome and other paraneoplastic syndromes. N. Engl. J. Med. 332: 1467-1474.
25. MORTON, M. E., T. N. CASSIDY, S. C. FROEHNER, B. P. GILMOUR & R. L. LAURENS. 1994. Alpha 1 and alpha 2 calcium channel subunit expression in human neuronal and small cell carcinoma cells. FASEB J. 8: 884-888.
26. 2+ channel complexes are Lambert-Eaton myasthenic syndrome antigens. Ann. Neurol. 33: 113-120.
27. ROTH, K. A. & J. D. BARCHAS. 1985. Small-cell lung carcinoma cell lines contain opioid peptides and receptors. Cancer Res. 45: 769-773.
28. MANECKJEE, R. & J. D. MINNA. 1994. Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth Differ. 5: 1033-1040.
29. 3 muscarinic acetylcholine receptors inhibits voltage-dependent calcium influx in small cell lung carcinoma. J. Biol. Chem. 265: 1443-1447.
30. VINCENT, A., B. LANG & J. NEWSOM-DAVIS. 1989. Autoimmunity to the voltage-gated calcium channel underlies the Lambert-Eaton myasthenic syndrome, a paraneoplastic disorder. Trends Neurosci. 12: 496-502.
31. SHER, E., E. BIANCARDI, M. PASSAFARO & F. CLEMENTI. 1991. Physiopathology of neuronal voltage-operated calcium channels. FASEB J. 5: 2677-2683.
32. KIM, Y. I. 1986. Passively tranferred Lambert-Eaton syndrome in mice receiving purified IgG. Muscle Nerve 9: 523-530.
33. LAMBERT, E. H. & V. A. LENNON. 1988. Selected IgGs rapidly induce Lambert-Eaton myasthenic syndrome in mice: complement independence and EMG abnormalities. Muscle Nerve 11: 1133-1145.
34. SMITH, D. O., M. W. CONKIN, P. J. JENSEN & W. D. ATCHISON. 1995. Decreased calcium currents in motor nerve terminals of mice with Lambert-Eaton myasthenic syndrome. J. Physiol. 487: 115-123.
35. 3H]acetylcholine release. Biochem. Pharmacol. 35: 3412-3414.
36. JOHNSTON, I., B. LANG, K. LEYS & J. NEWSOM-DAVIS. 1994. Heterogeneity of calcium channel autoantibodies detected using a small cell lung cancer line derived from a Lambert-Eaton myasthenic syndrome patient. Neurology 44: 334-338.
37. KIM, Y. I. & E. NEHER. 1988. IgG from patients with Lambert-Eaton syndrome blocks voltage-dependent calcium channels. Science 239: 405-408.
38. PEERS, J., B. LANG, J. NEWSOM-DAVIS & D. W. WRAY. 1990. Selective action of myasthenic syndrome antibodies on calcium channels in a rodent neuroblastoma × glioma cell line. J. Physiol. 421: 293-308.
39. KIM, Y. I., J. K. BLANDINO & T. J. O'SHAUGHNESSY. 1993. Inhibitory action of Lambert-Eaton syndrome IgG on calcium currents in a thyroid C-cell line. Ann. N.Y. Acad. Sci. 681: 398-401.
40. 2+ channels of human neuroblastoma IMR32 cells by Lambert-Eaton myasthenic syndrome (LEMS) IgGs. Neurosci. Lett. 181: 50-56.
41. 2+ currents in murine dorsal ganglion neurons. Proc. Natl. Acad. Sci. U.S.A. 93: 9264-9269.
42. GARCIA, K. D. & K. G. BEAM. 1996. Reduction of calcium currents by Lambert-Eaton syndrome sera: motoneurons are preferentially affected and L-type currents are spared. J. Neurosci. 16:4903-4913.
43. 2+ channels by Lambert-Eaton myasthenic syndrome (LEMS) antibodies in rat insulinoma RINm5F cells. FEBS Lett. 387: 47-52.
44. 2+ currents in human neuroblastoma IMR32 cells: kinetics, permeability, and pharmacology. Pflügers Arch. 416: 170-179.
45. 2+ channels in insulin-secreting cells. Eur. J. Pharmacol. 216: 407-414.
46. RICHMOND, J. E., E. SHER & I. COOKE. 1995. Characterization of the calcium currents in freshly dissociated crustacean peptidergic neuronal somata. J. Neurophysiol. 73: 2357-2368.
47. SHER, E., C. GOTTI, N. CANAL, C. SCOPPETTA, G. PICCOLO, A. EVOLI & F. CLEMENTI. 1989. Specificity of calcium channel autoantibodies in Lambert-Eaton myasthenic syndrome. Lancet 2: 640-643.
48. LENNON, V. A. & E. H. LAMBERT. 1989. Autoantibodies bind solubilized calcium channel-ω-conotoxin complexes from small cell lung carcinoma: a diagnostic aid for Lambert-Eaton myasthenic syndrome. Mayo Clin. Proc. 64: 1498-1504.
49. LEYS, K., B. LANG, I. JOHNSTON & J. NEWSOM-DAVIS. 1991. Calcium channel autoantibodies in the Lambert-Eaton myasthenic syndrome. Ann. Neurol. 29: 307-314.
50. PELUCCHI, A., E. CICERI, F. CLEMENTI, L. MARAZZINI, A. FORESI & E. SHER. 1993. Calcium channel autoantibodies in myasthenic syndrome and small cell lung cancer. Am. Rev. Respir. Dis. 147: 1229-1232.
51. MOTOMURA, M., A. SUENAGA, H. MATSUO, M. TSUJIHATA & S. NAGATAKI. 1994. Anti-voltage-gated calcium channel antibodies in the Lambert-Eaton myasthenic syndrome. Clin. Neurol. 34: 980-984.
52. MOTOMURA, M., I. JOHNSTON, B. LANG, A. VINCENT & J. NEWSOM-DAVIS. 1995. An improved diagnostic assay for Lambert-Eaton myasthenic syndrome. J. Neurol. Neurosurg. Psychiatry 58: 85-87.
53. SUENAGA, A., S. SHIRABE, T. NAKAMURA, M. MOTOMURA, M. TSUJIHATA, H. MATSUO, Y. KATAOKA, M. ITOH & S. NAGATAKI. 1996. Specificity of autoantibodies reactive with coconotoxin MVIIC-sensitive calcium channel in Lambert-Eaton myasthenic syndrome. Muscle Nerve 19: 1166-1168.
54. ARSAC, C., C. RAYMOND, N. MARTIN-MOUTOT, B. DARGENT, G. COURAUD, J. POUGET & M. SEAGAR. 1996. Immunoassays fail to detect antibodies against neuronal calcium channels in amyotrophic lateral sclerosis serum. Ann. Neurol. 40: 695-700.
55. PROTTI, D. A., R. REISIN, T. A. MACKINLEY & O. D. UCHITEL. 1996. Calcium channel blockers and transmitter release at the normal human neuromuscular junction. Neurology 46: 1391-1396.
56. PROTTI, D. A. & O. D. UCHITEL. 1993. Transmitter release and presynaptic calcium currents blocked by the spider toxin ω-Aga IVA. Neuroreport 5: 333-336.
57. TORRI-TARELLI, F., M. PASSAFARO, F. CLEMENTI & E. SHER. 1991. Presynaptic localization of ω-conotoxin-sensitive calcium channels at the frog neuromuscular junction. Brain Res. 547: 331-334.
58. ROSSONI, G., G. BERTI, L. LA MAESTRA & F. CLEMENTI. 1994. ω-Conotoxin GVIA binds to and blocks rat neuromuscular junction. Neurosci. Lett. 176: 185-188.
59. SHER, E. & F. CLEMENTI. 1991. ω-Conotoxin-sensitive voltage operated calcium channels in vertebrate cells. Neuroscience 42: 301-307.
60. DE LUCA, A., C. G. LI, M. J. RAND, J. J. REID, P. THAINA & H. K. WONG-DUSTING. 1990. Effects of ω-conotoxin GVIA on autonomic neuroeffector transmission in various tissues. Br. J. Pharmacol. 101: 437-447.
61. LOGIN, I. S., Y. I. KIM, A. M. JUDD, B. L. SPANGELO & R. M. MACLEOD. 1987. Immunoglobulins of Lambert-Eaton myasthenic syndrome inhibit rat pituitary hormone release. Ann. Neurol. 22: 610-614.
62. RICHMOND, J. E., A. CODIGNOLA, I. M. COOKE & E. SHER. 1996. Calcium- and barium-dependent exocytosis from the rat insulinoma cell line RINm5F assayed using membrane capacitance measurements and serotonin release. Pflügers Arch. 432: 258-269.