Naive human T cells develop into Th1 or Th0 effectors and exhibit cytotoxicity early after stimulation with Leishmania-infected macrophages

Journal of Infectious Diseases

Volumn 177, Issue 5, 1998, Pages 1345-1351

  Russo, Donna M ^a   Chakrabarti, Pampa ^a   Burns Jr , James M ^a  

^a MEHARRY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12;

ARTICLE; CONTROLLED STUDY; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LEISHMANIA; LEISHMANIA CHAGASI; LEISHMANIA DONOVANI; LEISHMANIASIS; LYMPHOCYTE PROLIFERATION; MACROPHAGE; PRIORITY JOURNAL; PROMASTIGOTE;

EID: 0031925540     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/515284     Document Type: Article

References (11)

1. Sacks D, Louis FA, Wirth DF. Leishmaniasis. In: Warren KS, ed. Immunology and molecular biology of parasitic infections. 3rd ed. Cambridge, MA: Blackwell Scientific Publications, 1993:237-68.
2. Reed SG, Scott P. T cell and cytokine responses in leishmaniasis. Curr Opin Immunol 1993;5:524-31.
3. Ho M, Koech DK, Iha DW, Bryceson AD. Immunosuppression in Kenyan visceral leishmaniasis. Clin Exp Immunol 1983;51:207-14.
4. Badaro R, Jones TC, Lorenco R, et al. A prospective study of visceral leishmaniasis in an endemic area of Brazil. J Infect Dis 1986;154:639-49.
5. Sacks DL, Lata Lal S, Shrivastava SN, Blackwell J, Neva FA. An analysis of T cell responsiveness in Indian kala-azar. J Immunol 1987;138:908-13.
6. Reed SG, Badaro R, Lloyd RMC. Identification of specific and crossreative antigens of Leishmania donovani chagasi by human infection serum. J Immunol 1997;138:1596-602.
7. +, major histocompatibility complex class II restricted T cells derived in vitro from lymphoid tissues of naive mice. J Exp Med 1993;178:101-11.
8. Pirmez C, Yamamura M, Uyemura D, Paies-Oliveira M, Conseicao-Silva F, Modlin RL. Cytokine patterns in the pathogenesis of human leishmaniasis. J Clin Invest 1993;91:1390-5.
9. Russo DM, Burns JM Jr, Carvalho E, et al. Human T cell responses to native and recombinant gp63. J Immunol 1991;147:3575-80.
10. Karp CL, El-Safi SH, Wynn TA, et al. In vivo cytokine profiles in patients with kala azar. Marked elevation of both interleukin 10 and interferon-gamma. J Clin Invest 1993;91:1644-8.
11. Ghalib HW, Piuvezam MR, Skeiky YA, et al. Interleukin 10 production correlates with pathology in human Leishmania donovani infections. J Clin Invest 1993;92:324-9.