Ethanol enhances cholesterol synthesis and secretion in human hepatomal cells

Alcohol

Volumn 15, Issue 4, 1998, Pages 299-303

  Visioli, Francesco ^a   Monti, Stefano ^a   Colombo, Claudio ^a   Galli, Claudio ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Alcohol; Atherosclerosis; Cholesterol; Ethanol; Hepatomal cells; Lipid metabolism; Phospholipids; Triglycerides

Indexed keywords

ACETALDEHYDE; ALCOHOL; CHOLESTEROL; PHOSPHOLIPID; TRIACYLGLYCEROL;

ALCOHOL CONSUMPTION; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; HEPATOMA CELL; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; LIPID METABOLISM;

ACETATES; CARCINOMA, HEPATOCELLULAR; CHOLESTEROL; ETHANOL; GLYCEROL; HUMANS; MEVALONIC ACID; PHOSPHOLIPIDS; TRIGLYCERIDES; TUMOR CELLS, CULTURED;

EID: 0031925284     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0741-8329(97)00133-X     Document Type: Article

References (25)

1. Austin M. A., Goto Y., Lenfant C., Tyroler H. A. The hypertriglyceridemias. Risk and management Epidemiology. Am. J. Cardiol. 68:1991;22A-25A.
2. Austin M. A., Hokanson J. E. Epidemiology of triglycerides, small dense low-density lipoprotein, and lipoprotein(a) as risk factors for coronary heart disease. Med. Clin. North Am. 78:1994;99-115.
3. Baraona A., Lieber C. S. Effects of ethanol on lipid metabolism. J. Lipid Res. 20:1979;289-315.
4. Barboriak J. J. Alcohol, lipids and heart disease. Alcohol. 1:1984;341-345.
5. Benoist F., Grand-Perret T. A sensitive method to analyze in vitro secretion of lipoproteins. distribution of apolipoproteins is modulated by oleic acid in HepG2 cells J. Lipid Res. 36:1995;2243-2250.
6. Cianflone K., Zhang Z., Vu H., Kohen-Avramoglu R., Kalant D., Sniderman A. D. The effect of individual amino acids on ApoB100 and Lp(a) secretion by HepG2 cells. J. Biol. Chem. 271:1996;29136-29145.
7. Clemens D. L., Halgard C. M., Miles R. R., Sorrel M. F., Tuma D. J. Establishment of a recombinant hepatic cell line stably expressing alcohol dehydrogenase. Arch. Biochem. Biophys. 321:1995;311-318.
8. Folch J., Lees M., Sloane Stanley G. H. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226:1957;497-509.
9. Klatsky A. L., Armstrong M. A., Friedman G. D. Alcohol and mortality. Ann. Intern. Med. 117(8):1992;646-654.
10. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
11. Levitt M. D., Levitt D. G., Furne J., DeMaster E. G. Can the liver account for first-pass metabolism of ethanol in the rat? Am. J. Physiol. 267:1994;G452-G457.
12. Lieber C. S. Alcohol and the liver. 1994 update Gastroenterology. 106:1994;1085-1105.
13. Lieber C. S. Medical disorder of alcoholism. N. Engl. J. Med. 333:1995;1058-1065.
14. Mead J. F., Alfin-Slater R. B., Howton D. R., Popjak G. Lipids. Chemistry, biochemistry, and nutrition. 1985;Plenum Press, New York.
15. Moore R. D., Pearson T. A. Moderate alcohol consumption and coronary artery disease. A review. Medicine. 65:1986;242-267.
16. Musanti R., Giorgini L., Lovisolo P. P., Pirillo A., Chiari A., Ghiselli G. Inhibition of acyl-CoA:cholesterol acyltransferase decreases apolipoprotein B-100-containing lipoprotein secretion from HepG2 cells. J. Lipid Res. 37:1996;1-14.
17. Rimm E. B., Klatsky A., Grobbee D., Stampfer M. J. Review of moderate alcohol consumption and reduced risk of coronary heart disease. Is the effects due to beer, wine, or spirits? Br. Med. J. 312:1996;731-736.
18. Ross R. The pathogenesis of atherosclerosis an uptade. N. Engl. J. Med. 314:1986;448-456.
19. Rudel L. L., Leathers C. W., Bond M. G., Bullock B. C. Dietary ethanol induced modifications in hyperlipoproteinemia and atherosclerosis in non human primates (Macaca nemestrina). Arteriosclerosis. 1:1981;144-155.
20. Shaper A. G., Wannamethee G., Walter M. Alcohol and mortality in British men. Explaining the U-shaped curve Lancet. 2:1988;1267-1273.
21. Steimberg D., Pearson T., Kuller L. Alcohol and atherosclerosis. Ann. Intern. Med. 114:1991;967-976.
22. Steinberg D. Lipoproteins and atherosclerosis. A look back and a look ahead Arteriosclerosis. 3:1983;283-330.
23. Syapin P. J., Noble E. P. Studies on ethanol's effects on cells in colture. Majchrowitz E., Noble E. P. Biochemistry and pharmacology of ethanol. 1980;Plenum Press, New York.
24. Taskinen M. R., Nikkila E. A., Valimaki M., Sane T., Kuusi T., Ketasiami A., Ylikamri R. Alcohol induced changes in serum lipoproteins and in their metabolism. Am. Heart J. 113:1987;458-464.
25. Wang T. W. M., Byrne C. D., Hales C. N. Effect of ethanol on hepatic apolipoprotein B synthesis and secretion in vitro. Biochim. Biophys. Acta. 1211:1994;234-238.