Neuroprotective efficacy and mechanisms of novel pyrrolopyrimidine lipid peroxidation inhibitors in the gerbil forebrain ischemia model

Journal of Cerebral Blood Flow and Metabolism

Volumn 18, Issue 5, 1998, Pages 539-547

  Oostveen, Jo A ^a   Dunn, Edwige ^a   Carter, Donald B ^a   Hall, Edward D ^a  

^a PFIZER INC   (United States)

Author keywords

Amyloid Precursor Protein; Apolipoprotein E; Astrocyte; Cerebral Ischemia; Gerbil; Hippocampal CA1; Lipid; Malondialdehyde; Microglia; Peroxidation; Pyrrolopyrimidine

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; DRUG VEHICLE; GLIAL FIBRILLARY ACIDIC PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MALONALDEHYDE; OXYGEN RADICAL; PYRROLOPYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; FOREBRAIN; GENE EXPRESSION; GERBIL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MALE; MICROGLIA; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0031924622     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199805000-00009     Document Type: Article

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