Clinical associations of lymphopenia in elderly persons admitted to acute medical and psychiatric wards

Gerontology

Volumn 44, Issue 3, 1998, Pages 168-171

  Dennis, Michael S ^a   Nicoloson, Anne ^b   Lehmann, Anthea B ^c   Junaid, Ola ^d   Jane Byrne, E ^e   Hopkinson, Neil ^f  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b WEST SUFFOLK HOSPITAL   (United Kingdom)

^c HOMERTON UNIVERSITY HOSPITAL   (United Kingdom)

^d NOTTINGHAM CITY HOSPITAL   (United Kingdom)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

^f ROYAL BOURNEMOUTH HOSPITAL   (United Kingdom)

Author keywords

Cognitive impairment; Elderly; Functional ability; Lymphopenia

Indexed keywords

AGED; ANTHROPOMETRY; ARTICLE; COGNITION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL;

AGED; AGED, 80 AND OVER; AGING; COGNITION DISORDERS; DISABILITY EVALUATION; FEMALE; HOSPITALS; HOSPITALS, PSYCHIATRIC; HUMANS; INPATIENTS; LYMPHOPENIA; SURVIVAL ANALYSIS;

EID: 0031924241     PISSN: 0304324X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000022003     Document Type: Article

References (30)

1. Caird F, Andrews R, Gallic T: The leukocyte count in old age. Age Ageing 1972;1:239-244.
2. Alexopoulos C, Babitas P: Age dependence of T lymphocytes (letter). Lancet 1976;i:426.
3. Augener W, Cohnen G, Reuter A, Brittinger G: Decrease of T lymphocytes during ageing (letter). Lancet 1974;i:1164.
4. De Paoli P, Battistin S, Santini GF: Age-related changes in human lymphocyte subsets: Progressive reduction in CD4 CD45R (suppressed inducer) population. Clin Immunol Immunopathol 1988;48:290-296.
5. Weksler ME: Senescence of the immune system. Med Gin North Am 1983;67:263-272.
6. Utsuyama M, Hirokawa K, Kurashima C, Fukayama M, Inamatsu T: Differential age-change in the numbers of CD4+CD45RA+ and CD4+CD29+ T cell subsets in human peripheral blood. Mech Ageing Dev 1992;63:57-68.
7. Ek A, Larsson J, von Schenck H, Thorslund S, et al: The correlation between energy, malnutrition and clinical outcome in an elderly hospital population. Clin Nutr 1990;9:185-189.
8. Lipschitz D, Mitchell C: The correctability of the nutritional, immune and haemopoietic manifestations of protein calories malnutrition in the elderly. J Am Coll Nutr 1982;1:17-25.
9. Chandra RK: Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 1992;340:1124-1127.
10. Proust J, Rosenzweig P, Debouzy C, Moulias R: Lymphopaenia induced by acute bacterial infections in the elderly: A sign of age-related immune dysfunction of major prognostic significance. Gerontology 1985;31:178-185.
11. Schleifer S, Keller S, Sires S, Davis K, Stein M: Depression and immunity, Arch Gen Psychiatry 1985;42:129-133.
12. Schleifer S, Keller S, Meyerson A, Raskin M, Davis K, Stein M: Lymphocyte function in major depressive disorder. Arch Gen Psychiatry 1984;41:484-486.
13. Tollefson GD, Godes M, Warren JB, Haus E, et al: Lymphopenia in primary degenerative dementia. J Psychiatr Res 1989;3/4:191-199.
14. Pirttila T, Mattinen S, Frey H: The decrease of CDS-positive lymphocytes in Alzheimer's disease. J Neurol Sci 1992;107:160-165.
15. Nicolson A, Junaid O, Byrne E, Dennis M, Lehmann A: Lymphopenia in elderly inpatients (letter). Postgrad Med J 1993;69:753-754.
16. Moran S: The spectrum of lymphopenia. Okla State Med Assoc J 1981;74:327-333.
17. Lehmann AB: Nutrition in old age: An update and questions for future research. 2. Rev Clin Gerontol 1991;1:231-240.
18. Barer D, Murphy J, Morrant J, Donald I: Acute hospital medical care for the elderly: Is there a valid performance indicator? Health Trends 1990;22:3-8.
19. Martin E, Alexander S, Farage D, Hassan W (eds): Hazards of Medication. A Manual of Drug Interactions, Incompatibilities, Contraindications and Adverse Effects. Philadelphia, Lippincott, 1971.
20. Davis DM (ed): Textbook of Adverse Drug Reactions, ed 2. Oxford, Oxford University Press, 1988.
21. Blackburn GL, Thornton PA: Nutritional assessment of the hospitalised patient. Symposium on Applied Nutrition in Clinical Medicine. Med Clin North Am 1979;63:1103-1115.
22. Mahoney FI, Barthel DW: Functional evaluation: The Barthel Index. Md State Med J 1965;14:61-65.
23. Collin C, Wade DT, Davies S, Home V: The Barthel ADL Index: A reliability study. Int Disabil Stud 1988;10:61-63.
24. Folstein MF, Holstein SE, McHugh PR: 'Mini-Mental State': A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
25. SPSS for Windows: Statistical Package for the Social Sciences. Chicago, SPSS, 1993.
26. Burr ML, Phillips KM: Antropometric norms in the elderly. Br J Nutr 1984;51:165-169.
27. Ardem M, Mayou R, Feldman E, Hawton K: Cognitive impairment in the elderly medically ill: How often is it missed? Int J Geriatr Psychiatry 1993;8:929-937.
28. Bowler C, Boyle A, Branford M, Cooper SA, Harper R, Lindesay J: Detection of psychiatric disorders in elderly medical inpatients. Age Ageing 1994;23:307-311.
29. Dysken MW, Minichiello MD, Hill JL, Skare S, Little JT, Molchan SE, Sunderland T: Distribution of peripheral lymphocytes in Alzheimer patients and controls. J Psychiatr Res 1992;26:213-218.
30. Chandra RK: Nutritional regulation of immunity and riks of infection in old age. Immunology 1989;67:141-147.