Cystothiazoles A and B, new bithiazole-type antibiotics from the myxobacterium Cystobacter fuscus

Journal of Antibiotics

Volumn 51, Issue 3, 1998, Pages 275-281

  Ojika, Makoto ^a   Suzuki, Yoshihiro ^a   Tsukamoto, Akane ^a   Sakagami, Youji ^a   Fudou, Ryosuke ^b   Yoshimura, Toshihiko ^b   Yamanaka, Shigeru ^b  

^a NAGOYA UNIVERSITY   (Japan)

^b AJINOMOTO CO INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CYSTOTHIAZOLE A; CYSTOTHIAZOLE B; MYXOTHIAZOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INHIBITION; FERMENTATION; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; MITOCHONDRIAL MEMBRANE; MYXOCOCCALES; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; ULTRAVIOLET SPECTROSCOPY;

CYSTOBACTER FUSCUS;

EID: 0031923545     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.51.275     Document Type: Article

References (10)

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2. WESSJOHANN, L.: Epothilones: promising natural products with taxol-like activity. Angew. Chem. Int. Ed. Engl. 36: 715-718, 1997 and literatures cited herein
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4. SAKAGAMI, Y.; A. SANO, O. HARA, T. MIKAWA & S. MARUMO: Cladosporol, β-1,3-glucan biosynthesis inhibitor, isolated from fungus, Cladosporium cladosporioides. Tetrahedron Lett. 36: 1469-1472, 1995
5. GERTH, K.; H. IRSCHIK, H. REICHENBACH & W. TROWITZSCH: Myxothiazol, an antibiotic from Myxococcus fulvus (Myxobacterales) I. Cultivation, isolation, physico-chemical and biological properties. J. Antibiotics 33: 1474-1479, 1980
6. TROWITZSCH. W.; G. HÖFLE & W. S. SHELDRICK: The stereochemistry of myxothiazol. Tetrahedron Lett. 22: 3829-3832, 1981
7. Myxothiazol was obtained by Chromatographic separations from a myxobacterium isolated in our laboratory (Myxococcus fulvus M-219).
8. 1 segment of the respiratory chain. Biochim. Biophys. Acta 638: 282-289, 1981
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