The effect of flufenamic acid on gastrointestinal myoelectrical activity and transit time in dogs

Gut

Volumn 42, Issue 2, 1998, Pages 258-265

  Farrugia, G ^a   Nitecki, S ^b   Harty, G J ^b   Camilleri, M ^b   Szurszewski, J H ^b  

^a MAYO CLINIC   (United States)

^b Dept of Physiology and Biophysics ^*

Author keywords

Migrating motor complex; Prokinetic agents; Transit studies

Indexed keywords

FLUFENAMIC ACID;

ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG EFFECT; FEMALE; INTESTINE MOTILITY; INTESTINE MUSCLE; MYOELECTRIC CONTROL; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; STOMACH EMPTYING; STOMACH MUSCLE;

EID: 0031923421     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.42.2.258     Document Type: Article

References (22)

1. Glazko AJ. Experimental observations of flufenamic, mefenamic and meclofenamic acids. Part III. Metabolic disposition, in fenamates in medicine. Ann Phys Med Suppl 1967;8:23 36.
2. Hart FD. Treatment of the arthropathies with antiinflammatory compounds. In: Williamson NWR, ed. Antiinflammatory compounds. New York: Dekker, 1987:23 86.
3. Terada H, Muraoka S, Fujita T. Structure-activity relationships of fenamic acids. J Med Chem 1974;17:330 4.
4. Oradell NJ. Physiciants desk reference. Medical Economics, 1989:1590.
5. Bennet A, Hensby G. Sanger GJ, Stamford IF. Metabolites of arachidonic acid formed by human intestinal tissues and their action on the muscle layers. Br J Pharmacol 1981;74: 435 44.
6. Sanger GJ, Bennet A. Regional differences in the responses to prostanoids of circular muscle from guinea-pig isolated intestine. J Pharm Pharmacol 1980;32:705 8.
7. Farrugia G, Camilleri M, Whitehead W. Therapeutic strategies for motility disorders. Gastroenterol Clin. North Am 1996;25:225 46.
8. Knauf PA, Mann NA. Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system. J Gen Physiol 1984;83:703 25.
9. Gogelein H, Dahlem D, Englert HC, Lang HJ. Flufenamic acid, mefenamic acid and niflumic acid inhibit single non-selective cation channels in the rat exocrine pancreas. FEBS Lett 1990;268:79-82.
10. Gogelein H, Pfannmuller B. The nonselective cation channel in the basolateral membrane of rat exocrine pancreas. Pflugers Arch 1989;413:287-98.
11. 2+-activated Cl channels in Xenopus oocytes. Mol Pharmacol 1990;37:720-4.
12. Ca channels by niflumic, flufenamic, and mefenamic acids. Biophys J 1994;67:2272-9.
13. Rae JL, Farrugia G. A whole cell potassium current in rabbit corneal epithelium activated by fenamates. J Membr Biol 1992;129:81-97.
14. Farrugia G, Rae JL, Szurszewski JH. Characterization of a delayed rectifier in canine jejunal circular smooth muscle and its activation by fenamates. J Physiol 1993;468:297-310.
15. Farrugia G, Rae JL, Sarr M, Szurszewski JH. A potassium whole cell current in jejunal human circular smooth muscle. Am J Physiol 1993;265:G873-9.
16. Nitecki S, Farrugia G, Rich A, Szurszewski JH. Effects of flufenamic acid in vivo on MMC activity and in vitro on intracellular calcium in the canine lower small intestine. Gastroenterology 1994;107:1226.
17. Nitecki S, Karmeli R, Harry GJ, Kamei C, Yaksh TL, Szurszewski JH. Long-term perfusion of the cerebroventricular system of dogs without leakage to the peripheral circulation. Am J Physiol 1994;267:R1309-19.
18. Camilleri M, Zinsmeister AR, Greydanus MP, Brown ML, Proano M. Towards a less costly but accurate test of gastric emptying and small bowel transit. Dig Dis Sci 1991;36:609 15.
19. von der Ohe MR, Camilleri M. Measurement of small bowel and colonic transit: indications and methods. Mayo Clin Proc 1992;67:1169-79.
20. Wen J, Phillips SF, Kost L. Scintigraphic measurement of regional gut transit in the dog (abstract). Gastroenterology 1995;108(suppl):A709.
21. Nguyen A, Camilleri M, Kost LJ, et al. SDZ HTF919 stimulates canine colonic motility and transit in vivo. J Pharmacol Exp Ther 1997;280:1270-6.
22. Arai I, Hamasaka Y, Futaki N, et al. Effect of NS-398, a new nonsteroidal anti-inflammatory agent, on gastric ulceration and acid secretion in rats. Res Commun Chem Pathol Pharmacol 1993;81:259-70.