Lack of effect of gemfibrozil on cyclosporine blood concentrations in kidney-transplanted patients

American Journal of Nephrology

Volumn 18, Issue 3, 1998, Pages 199-203

  Pisanti, Nicola ^a,c   Stanziale, Pasquale ^a   Imperatore, Paola ^a   D'Alessandro, Riccardo ^a   De Marino, Valeria ^b   Capone, Domenico ^a   De Marino, Vincenzo ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c Policlinico   (Italy)

Author keywords

Cyclosporine; Drug interaction; Gemfibrozil; Kidney transplant

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; GEMFIBROZIL; METHYLPREDNISOLONE; PREDNISONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CHOICE; DRUG INTERACTION; FEMALE; HUMAN; HUMAN TISSUE; HYPERTRIGLYCERIDEMIA; KIDNEY TRANSPLANTATION; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SURGICAL PATIENT;

ADULT; ANTILIPEMIC AGENTS; CYCLOSPORINE; DRUG INTERACTIONS; FEMALE; GEMFIBROZIL; HUMANS; HYPERTRIGLYCERIDEMIA; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; TIME FACTORS;

EID: 0031922887     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000013337     Document Type: Article

References (19)

1. Wauters JP, Rosman JB, Descombes E, Genton A, Mosimann F: Ten year experience with low-dose cyclosporin A in renal transplantation. Transplant Proc 1994;26:2528-2529.
2. Ballantyne CM, Jones PH, Payton-Ross C, Patsch W, Short HD III, Noon GP, Gotto AM Jr, DeBakey ME, Young JB: Hyperlipemia following heart transplantation: Natural history and intervention with mevinolin (lovastatin). Transplant Proc 1987;19:60-62.
3. Rodighiero V: Therapeutic drug monitoring of cyclosporin. Practical applications and limitations. Clin Pharmacokinet 1989;16:27-37.
4. Study Group, European Atherosclerosis Society: The recognition and management of hyperlipidaemia in adults: A policy statement of the European Atherosclerosis Society. Eur Heart J 1988;9:571-600.
5. 125I]radioimmunoassay. Ther Drug Monit 1992;14:226-233.
6. Capone D, Stanziale P, Balletta MM, Imperatore P, De Marino V, Pisanti N: Evaluation of monoclonal/polyclonal ratio in kidney-transplanted patients treated with cyclosporine. Int J Clin Pharmacol Res 1992;12:123-128.
7. Keogh A, Day R, Critchley L, Duggin G, Baron D: The effect of food and cholestyramine on the absorption of cyclosporine in cardiac transplant recipients. Transplant Proc 1988;20:27-30.
8. Nemunaitis J, Deeg HJ, Yee GC: High cyclosporine levels after bone marrow transplantation associated with hypertriglyceridaemia. Lancet 1986;ii:744-745.
9. Lopez-Miranda J, Peréz-Jiménez F, Torres A, Espino-Montoro A, Gomez P, Hidalgo-Rojas L, Ordovas JM, Jiménez-Perepérez JA: Effect of cyclosporin on plasma lipoproteins in bone marrow transplantation patients. Clin Biochem 1992;25:379-386.
10. Grossman RM, Delaney RJ, Brinton EA, Carter DM, Gottlieb AB: Hypertriglyceridemia in patients with psoriasis treated with cyclosporine. J Am Acad Dermatol 1991;25:648-651.
11. Lopez-Miranda J, Pérez-Jiménez F, Gomez-Gerique JA, Espino-Montoro A, Hidalgo-Rojas L, Pedreno J, Jiménez-Perepérez JA: Effect of cyclosporin on plasma lipoprotein lipase activity in rats. Clin Biochem 1992;25:387-394.
12. Cattran DC, Steiner G, Wilson DR, Fenton SSA: Hyperlipidemia after renal transplantation: Natural history and pathophysiology. Ann Intern Med 1979;91:554-559.
13. Ibels LS, Alfrey AC, Weil R: Hyperlipidemia in adult, pediatric and diabetic renal transplant recipients. Am J Med 1978;64:634-642.
14. Thiel G, Fellmann T, Rosman J, Bock A, Landmann J, Mihatsch M; Long-term safety profile of Sandimmune m renal transplantation. Transplant Proc 1992;24:71-77.
15. Witztum JL: Drug used in the treatment of hyperlipoproteinemias; in Goodman, Gilman (eds): The Pharmacological Basis of Therapeutics. New York, McGraw-Hill, 1996, pp 875-897.
16. Pflugfelder PW, Huff M, Oskalns R, Rudas L, Kostuk WJ: Cholesterol-lowering therapy after heart transplantation: A 12-month randomized trial. J Heart Lung Transplant 1995;14:613-622.
17. Traindl O, Reading S, Franz M, Falger S, Klauser R, Gisinger J, Widhalm K, Kovarik J: Low-dose lovastatin in hyperlipidemic kidney graft recipients with cyclosporin A. Transplant Proc 1992;24:2745-2747.
18. Homan van der Heide JJ, Bilo HJG, Tegzess AM, Donker AJM: The effects of dietary supplementation with fish oil on renal function in cyclosporin-treated renal transplant recipients. Transplantation 1990;49:523-526.
19. Homan van der Heide JJ, Bilo HJG, Donker AJM, Wilmink JM, Sluiter WJ, Tegzess AM: The effects of dietary supplementation with fish oil on renal function and the course of early postoperative rejection episodes in cyclosporine-treated renal transplant recipients. Transplantation 1992;54:257-263.