Proteinuria and renal tubular damage: Urinary N-acetyl-β-D-glucosaminidase and isoenzymes in dissimilar renal disease

American Journal of Nephrology

Volumn 18, Issue 3, 1998, Pages 179-185

  Rustom, Rana ^a   Costigan, Michael ^a   Shenkin, Alan ^a   Bone, J Michael ^a  

^a ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Isoenzymes; N acetyl D glucosaminidase; Proteinuria; Renal failure; Tubular injury hyperfunction

Indexed keywords

ISOENZYME; MARKER; N ACETYL BETA GLUCOSAMINIDASE;

ADULT; AGED; ARTICLE; CHRONIC PYELONEPHRITIS; CONTROLLED STUDY; CORRELATION FUNCTION; DIABETIC NEPHROPATHY; FAST PROTEIN LIQUID CHROMATOGRAPHY; GLOMERULONEPHRITIS; HUMAN; HUMAN TISSUE; KIDNEY DISEASE; KIDNEY FUNCTION TEST; KIDNEY TUBULE DISORDER; MAJOR CLINICAL STUDY; NEPHROSCLEROSIS; PRIORITY JOURNAL; PROTEINURIA; URINE LEVEL;

ACETYLGLUCOSAMINIDASE; ADULT; AGED; CASE-CONTROL STUDIES; CHROMATOGRAPHY, LIQUID; ENZYME TESTS; HUMANS; ISOENZYMES; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; KIDNEY TUBULES; MIDDLE AGED; PROTEINURIA;

EID: 0031922886     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000013334     Document Type: Article

References (24)

1. Bohle A, Mackensen-Haen S, von Gise H, Grund KE, Wehrmann M, Batz Ch, Bogenschütz O, Schmitt H, Nagy J, Müller C. Müller G: The consequences of tubulo-interstitial changes for renal function in glomerulopathies. Pathol Res Pract 1990;186:135-144.
2. Williams PS, Fass G, Bone JM: Renal pathology and proteinuria determine progression in untreated mild/moderate chronic renal failure. Q J Med 1988;67:252:343-354.
3. 99mTc and urinary ammonia: Effects of proteinuria. Miner Electrolyte Metab 1992;18:108-112.
4. Rustom R, Maltby P, Jackson MJ, Stockdale HR, Critchley M, Bone JM: Renal tubular protein degradation and urinary ammonia in chronic renal failure. Nephrol Dial Transplant 1992;7:1153.
5. Clark EC, Nath KA, Hostetter MK, Hostetter TH: Role of ammonia in progressive interstitial nephritis. Am J Kidney Dis 1991;5:15-19.
6. Harris DCH, Chan I, Schrier RW: Remnant kidney hypermetabolism and progression of chronic renal failure. Am J Physiol 1988;254: F267-F276.
7. Kaysen GA, Hutchison FN, Bander ALH: The effect of the nephrotic syndrome on the renal handling of protein and other nutrients. Semin Nephrol 1990;10:481-490.
8. Bernard AM, Vyskocil AA, Mahieu P, Lauwerys RR: Assessment of urinary retinol-binding protein as an index of proximal tubular injury. Clin Chem 1987;33:775-779.
9. Piscator M: Early detection of tubular dysfunction. Kidney Int 1991;34(suppl):15-17.
10. Shibasaki T, Gomi H, Ishimoto F, Miyahara T: Urinary N-acetyl-beta-D-glucosaminidase isoenzyme activity as measured by fast protein liquid chromatography in patients with nephrotic syndrome. Clin Chem 1990;36:102-103.
11. Costigan M, Rustom R, Bone JM, Shenkin A: Origin and significance of urinary n-acetyl-̀-β-D-glucosaminidase (NAG) in renal patients with proteinuria. Clin Chim Acta 1996;255:133-144.
12. Maruhn D: Rapid colorimetric assay of galactoside and N-acetyl-glucosaminidase in human urine. Clin Chim Acta 1976;73:453-461.
13. Watanabe N, Kamel S, Ohkubo A, Yamanaka M, Ohsawa S, Makino K, Tokuda K: Urinary protein as measured with pyrogallol red-molybdate complex: Manually and in a Hitachi 726 automated analyser. Clin Chem 1986;32:1551.
14. Jung K: Urinary enzymes and low molecular weight proteins as markers of tubular dysfunction. Kidney Int 1994;47(suppl):29-33.
15. Price RG: The role of NAG (N-acetyl-beta-D-glucosaminidase) in the diagnosis of kidney disease including the monitoring of nephrotoxicity. Clin Nephrol 1992:38(suppl):14-19.
16. Ellis BG, Tucker SM, Thompson AE, Price RG: Presence of serum and tissue forms of N-acetyl-β-D-glucosaminidase in urine from patients with renal disease. Clin Chim Acta 1975;64:195-202.
17. Ring E, Zobel G, Erwa W, Haim-Kutting M: Urinary excretion of N-acetyl-β-D-glucosaminidase in proteinuric states. Child Nephrol Urol 1992;12:15-18.
18. Hultberg B: Urinary excretion of β-hexosaminidase in different forms of protemuria. Clin Chim Acta 1980;108:195-199.
19. Tsau YK, Chen CH, Yang LF, Sheu JN: Urinary acetyl-beta-glucosaminidase in children with idiopathic nephrotic syndrome. Acta Paediatr Sin 1991;32:286-290.
20. 2-glycoprotem-1 (apolipoprotein H) and other markers of tubular malfunction in 'non-tubular' renal disease. J Clin Pathol 1992;45:561-567.
21. Miralles JM, Velasco J, Villabona V, SanchezBernal C, Perez N, Corrales JJ, Garcia Diez LC, Villar E: Prospective study of the enzymatic activities in urine of N-acetyl-beta-D-glucosaminidase, alpha- and beta-D-glucosidases, alpha-L- and beta-D-fructosidases. and beta-D-galactosidase in type I diabetes mellitus with early nephropathy. Diabetes Complications 1993;7:199-203.
22. Ikenaga H, Suzuki H, Ishii N, Itoh H, Saruta T: Enzymuria in non-insulin-dependent diabetic patients: Signs of tubular cell dysfunction. Clin Sci 1993;84:469-475.
23. Jones AP, Lock S, Griffiths KD: Urinary N-acetyl-beta-glucosaminidase activity in type I diabetes mellitus. Ann Clin Biochem 1999;32: 58-62.
24. 2-Glycoprotein-1 (apolipoprotein H) excretion and renal tubular malfunction in diabetic patients without clinical proteinuria. J Clin Pathol 1993;46:465-469.