Assessment of reperfused myocardium using a new ischaemia-avid imaging agent, technetium-99m HL91: Comparison with myocardial glucose uptake

European Journal of Nuclear Medicine

Volumn 25, Issue 4, 1998, Pages 361-366

  Fukuchi, Kazuki ^a   Kusuoka, Hideo ^a   Yutani, Kenji ^a   Hasegawa, Shinji ^a   Nishimura, Tsunehiko ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Carbon 14 2 de oxyglucose; Dual tracer autoradiography; Myocardial ischaemia; Reperfusion; Technetium 99m hl91

Indexed keywords

CARBON 14; DEOXYGLUCOSE; TECHNETIUM 99M;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CORONARY ARTERY LIGATION; GLUCOSE METABOLISM; HEART MUSCLE ISCHEMIA; HEART VENTRICLE SEPTUM; INTERMETHOD COMPARISON; INTRAVENOUS DRUG ADMINISTRATION; LEFT CORONARY ARTERY; MALE; NONHUMAN; RAT; TIME;

ANIMALS; AUTORADIOGRAPHY; CARBON RADIOISOTOPES; DEOXYGLUCOSE; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIAL STUNNING; MYOCARDIUM; ORGANOTECHNETIUM COMPOUNDS; OXIMES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031922654     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002590050233     Document Type: Article

References (24)

1. Tamaki N, Yonekura Y, Yamashita K, Saji H, Magata Y, Senda M, Konishi Y, Hirata K, Ban T, Konish J. Positron emission tomography using fluorine-18 deoxyglucose in evaluation of coronary artery bypass grafting. Am J Cardiol 1989; 64:860-865.
2. Kalff V, Schwaiger M, Nguyen N, McClanahan TB, Gallagher KP. The relationship between myocardial blood flow and glucose uptake in ischaemic canine myocardium determined with fluorine-18-deoxyglucose. J Nucl Med 1992; 33:1346-1353.
3. Prellwitz JA, Vasta MC, Sunderlamd JJ, Shiue CY, Gupta MC, Frick MP. Investigation of factors influencing FDG myocardial image quality [abstract]. J Nucl Med 1991; 32:1039.
4. Chapman JD, Franko AJ, Sharplin J. A marker for hypoxic cells in tumors with potential clinical applicability. Br J Cancer 1981; 43:546-550.
5. Linder KE, Chan YW, Cyr JE, Malley MF, Nowotnik DP, Nunn AD. TcO(PnA.O-1-(2-nitroimidazole)) [BMS-181321], a new technetium-containing nitroimidazole complex for imaging hypoxia: synthesis, characterization, and xanthine oxidase-catalyzed reduction. J Med Chem 1994; 37: 9-17.
6. Chapman JD, Baer K, Lee J. Characteristics of the metabolism-induced binding of misonidazole to hypoxic mammalian cells. Cancer Res 1983; 43:1523-1528.
7. Kusuoka H, Hashimoto K, Fukuchi K, Nishimura T. Kinetics of a putative hypoxic tissue marker, technetium-99m nitroimidazole (BMS181321), in normoxic, hypoxic, ischaemic, and stunned myocardium. J Nucl Med 1994; 35:1371-1376.
8. Rumsey WL, Kuczynski B, Patel B, Bauer A, Narra RK, Eaton SM, Nun AD, Strauss HW. SPECT imaging of ischaemic myocardium using a technetium-99m-nitroimidazole Iigand. J Nucl Med 1995; 36:1445-1450.
9. Fukuchi K, Kusuoka H, Watanabe Y, Fujiwara T, Nishimura T. Ischemic and reperfused myocardium detected with technetium-99m nitroimidazole. J Nucl Med 1996; 37:374-379.
10. Archer CM, Edwards B, Kelly JD. King AC, Burke JF, Riley ALM. Technetium labelled agents for imaging tissue hypoxia in vivo. In: Nicolini M, Bandoli G. Mazzi U, eds. Technetium and rhenium in chemistry and nuclear medicine. Padova, Italy: SGE Ditoriali; 1995:535-539.
11. Okada RD, Johnson G III, Nguyen KN, Edwards B, Archer CM, Kelly JD. 99mTc-HL91: effects of low flow and hypoxia on a new ischaemia-avid imaging agent. Circulation 1997; 95:1892-1899.
12. Okada RD, Nguyen KN, Lauinger M, Allton IL, Johnson G III. Technetium 99m-Q12 kinetics in perfused rat myocardium: effects of hypoxia and low flow. Am Heart J 1996; 132: 108-115.
13. Johnson G III, Nguyen KN, Liu Z, Gao P, Edwards B, Archer CM, King AC, North TL, Okada RD. HL-91-technetium-99m: kinetics of a new hypoxic avid imaging agent in normal and ischaemic myocardium as assessed by gamma camera images [abstract]. J Am Coll Cardiol 1996; 27:407A.
14. Johnson G III, Nguyen KN, Edwards B, Archer CM, Okada RD. HL91-technetium-99m: uptake and retention of a new hypoxia avid imaging agent can differentiate ischaemic viable from ischaemic nonviable myocardium [abstract]. Circulation 1995; 92:I-788.
15. Braunwald E, Kloner R. The stunned myocardium: Prolonged, postischaemic ventricular dysfunction. Circulation 1982; 66:1146-1149.
16. Wijns W, Melin JA, Leners N. Ferrant A, Keyeux A, Rahier J, Cogneau M, Michel C, Bol A, Robert A. Accumulation of polymorphonuclear leukocytes in reperfused ischaemic canine myocardium: relation with tissue viability assessed by fluorine- 18-2-deoxyglucose uptake. J Nucl Med 1988; 29:1826-1832.
17. Sun D, Nguyen N, DeGrado TR, Schwaiger M, Brosius FC III. Ischemia induces translocation of the insulin-responsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes. Circulation 1994: 89:793-798.
18. Hashimoto K, Nishimura T, Ishikawa M, Koga K, Mori T, Matsuda S, Hori M, Kusuoka H. Enhancement of glucose uptake in stunned myocardium: role of glucose transporter. Am J Physiol 1997; 272:H1122-1130.
19. McFalls EO, Ward H, Fashingbauer P, Gimmestad G. Palmer B. Myocardial blood flow and FDG retention in acutely stunned porcine myocardium. J Nucl Med 1995; 36:637-643.
20. Caldwell JH, Revenaugh JR, Martin GV, Johnson PM, Rasey JS, Krohn KA. Comparison of fluorine- 18-fluorodeoxyglucose and tritiated fluoromisonidazole uptake during low-How ischaemia. J Nucl Med 1995; 36:1633-1638.
21. Buxton DB, Mody FV, Krivokapich J, Phelps ME, Schelbert HR. Quantitative assessment of prolonged metabolic abnormalities in reperfused canine myocardium. Circulation 1992; 85:1842-1856.
22. Sebree L, Bianco JA, Subramanian R, et al. Discordance between accumulation of C-14 deoxyglucose and T1-201 in reperfused myocardium. J Mol Cell Cardiol 1991; 23:603-616.
23. 18F]2-deoxy-2-fluoro-D-glucose for assessing myocardial glucose uptake. Circulation 1995; 91:2435-2444.
24. Hashimoto K, Uehara T, Ishida Y, Nonogi H, Kusuoka H, Nishimura T. Paradoxical uptake of F-18 fluorodeoxyglucose by successfully reperfused myocardium during the sub-acute phase in patients with acute myocardial infarction. Ann Nucl Med 1996; 10:93-98.