Lactulose and neomycin attenuate leukocyte-endothelial cell adhesion in an animal model of inflammatory bowel disease

European Journal of Gastroenterology and Hepatology

Volumn 10, Issue 4, 1998, Pages 339-343

  Arndt, Holger ^a   Schölmerich, Jürgen ^a   Palitzsch, Klaus Dieter ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Indomethacin; Inflammatory bowel disease; Intravital microscopy; Lactulose; Neomycin

Indexed keywords

INDOMETACIN; LACTULOSE; NEOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENTERITIS; ERYTHROCYTE; FECES ANALYSIS; ILEITIS; INTESTINE EPITHELIUM; LEUKOCYTE; LEUKOCYTE ADHERENCE; MACROPHAGE; MALE; MESENTERIC VEIN; MICROSCOPY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; VEIN BLOOD FLOW;

EID: 0031921866     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-199804000-00011     Document Type: Article

References (30)

1. Bargen JA. Experimental studies on the etiology of chronic ulcerative colitis. JAMA 1924; 83:332-336.
2. Sartor RB, Rath HC, Sellon RK. Microbial factors in chronic intestinal inflammation. Curr Opinion Gastroenterol 1996; 12:327-333.
3. Robert A, Asano T. Resistance of germfree rats to indomethacin-induced intestinal lesions. Prostaglandins 1977; 14:333-341.
4. Yamada T, Deitch E, Specian RD, et al. Mechanisms of acute and chronic intestinal inflammation induced by indomethacin. Inflammation 1993; 17:641-662.
5. Arfors K-E, Lumberg C, Lindholm L, et al. A monoclonal antibody to the membrane glycoprotein complex CDw18 (LFA) inhibits PMN accumulation and plasma leakage in vivo. Prog Appl Microcirc 1987; 11:270-275.
6. Grisham MB, Everse J, Janssen HF. Endotoxemia and neutrophil activation in vivo. Am J Physiol 1988; 254:H1017-H1022.
7. Kent TH, Cardelli RM, Stamler FW. Small intestinal ulcers and intestinal flora in rats given indomethacin. Am J Pathol 1969; 54:231-245.
8. Fang W-F, Broughton A, Jacobson ED. Indomethacin-induced intestinal inflammation. Dig Dis 1977; 22:749-760.
9. Satoh H, Guth PH, Grossman MI. Role of bacteria in gastric ulceration produced by indomethacin in the rat. Gastroenterology 1983; 84:483-489.
10. Arndt H, Palitzsch K-D, Grisham MB, et al. Metronidazole inhibits leukocyte-endothelial cell adhesion in rat mesenteric venules. Gastroenterology 1994; 106:1271-1276.
11. Granger DN, Benoit JN, Suzuki M, et al. Leukocyte adherence to venular endothelium during ischemia/reperfusion. Am J Physiol 1989; 257:G683-G688.
12. Davis MJ. Determination of volumetric flow in capillary tubes using an optical Doppler velocimeter. Microvasc Res 1987; 34:223-230.
13. House SD, Lipowsky H. Leukocyte-endothelium adhesion: microhemodynamics in mesentery of the cat. Microvasc Res 1987; 34:363-379.
14. Rutgeerts P, Hiele M, Geboes K, et al. Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection. Gastroenterology 1995; 108:1617-1621.
15. Greenblom SL, Steinhart AH, Greenberg GR. Ciprofloxacin and metronidazole: combination antibiotic therapy for ileocolonic Crohn's disease. Gastroentemlogy 1995; 108:A826 (abstract).
16. Onderdonk AB, Hermos JA, Dzink JL, et al. Protective effect of metronidazole in experimental ulcerative colitis. Gastroenterology 1978; 74:521-526.
17. Videla S, Vilaseca J, Guarner F, et al. Role of intestinal microflora in chronic inflammation and ulceration of the rat colon. Gut 1994; 35:1090-1097.
18. 2μ transgenic (TG) rats: a pathogenic role for anaerobic bacteria. Clin Immunol Immunopathol 1995; 76:S45 (abstract).
19. Ballongue J, Crociani J, Grill JP. In vitro study on the effect of lactose and lactitol on growth and metabolism of intestinal bacteria. Gut 1995; 37:A48 (abstract).
20. Mao Y, Nobaek S, Kasravi B, et al. The effects of Lactobacillus strains and oat fibre on methotrexate-induced enterocolitis in rats. Gastroenterology 1996; 111:334-344.
21. Svensjö E, Erlansson M, van den Bos GC. Endotoxin-induced increase in leukocyte adherence and macromolecular permeability of postcapillary venules. Agents Actions 1990; 29:21-23.
22. Fukumura D, Miura S, Kurose I, et al. IL-1 is an important mediator for microcirculatory changes in endoloxin-induced intestinal mucosal damage. Dig Dis Sci 1996; 41:2482-2492.
23. Perry MA, Panes J. Modulation of ICAM-1 expression in endotoxemia. Int J Microcirc Clin Exp 1996; 16:S84 (abstract).
24. Arndt H, Palitzsch K-D, Schölmerich J. Leukocyte-endothelial cell adhesion in indomethacin-induced intestinal inflammation is correlated with fecal pH. Gut, in press.
25. 2 and nonsteroidal antiinflammatory drugs. Dig Dis Sci 1986; 31:631-637.
26. Attebery HR, Sutter VL, Finegold SM. Effect of a partially chemically defined diet on human fecal flora. Am J Clin Nutr 1972; 25:1391-1398.
27. Kruis W, Kalek HD, Stellaard F, et al. Altered fecal bile acid pattern in patients with inflammatory bowel disease. Digestion 1986; 35:189-198.
28. Enss ML, Grosse-Siestrup H, Riedesel H. Acidification of the colonic mucins following polyvalent colonization of the germ-free rat. J Vet Med 1992; 39:503-512.
29. Arndt H, Palitzsch K-D, Anderson DC, et al. Leukocyte-endothelial cell adhesion in a model of intestinal inflammation. Gut 1995; 37:374-379.
30. Nygard G, Anthony A, Piasecki C, et al. Acute indomethacin-induced jejunal injury in the rat: early morphological and biochemical changes. Gastroenterology 1994; 106:567-575.