The immunological co-adjuvant action of liposomal interleukin-2: The role of mode of localisation of the cytokine and antigen in the vesicles

Journal of Drug Targeting

Volumn 5, Issue 2, 1998, Pages 93-98

  Gursel, Mayda ^a,b   Gregoriadis, Gregory ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b MIDDLE EAST TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Immune response; Immunological adjuvants; Interleukin 2; Liposomes; Tetanus toxoid

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 2; TETANUS TOXOID; TOXOID; VACCINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SECONDARY IMMUNE RESPONSE;

EID: 0031921712     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869808995862     Document Type: Article

References (28)

1. Abraham E. and Shah S., (1991) Intranasal immunization with liposomes containing IL-2 enhances bacterial polysaccharide antigen-specific pulmonary secretory antibody response. J.Immunol., 149, 3719
2. Alving C. R., (1991) Liposomes as carriers of antigens and adjuvants, J. Immunol. Meth., 140, 1-13
3. Anderson P. M., Hasz D., Dickrell L. and Sencer S., (1992) Interleukin-2 in liposomes: Increased intravenous potency and less pulmonary toxicity in the rat. Drug Dev. Res., 27, 15
4. 1). J. Immunol., 137, 3205-3210
5. Carding S. R., Hayday A. C. and Bottomly K., (1991) Cytokines in T-cell development. Immunol. Today, 12, 239-245
6. Gursel M. and Gregoriadis G., (1997) Interleukin-15 acts as an immunological co-adjuvant for liposomal antigen in vivo. Immunology Lett., in press
7. Gregoriadis G., (1990) Immunological adjuvants: A role for liposomes, Immunol. Today., 11, 89-97
8. Gregoriadis G., (1996) Engineering liposomes for drug delivery: progress and problems. Trends in Biotechnology, 13, 527-537
9. Gregoriadis G., Davis D. and Davies A., (1987) Liposomes as immunological adjuvants: Antigen incorporation studies, Vaccine., 5, 143-149
10. Gregoriadis G., Garçon N., da Silva H. and Stenberg B., (1993) Coupling of ligands to liposomes independently of solute entrapment: Observations on the formed vesicles. Biochim. Biophys. Acta, 1147, 185-193
11. Gregoriadis G. and Florence A T., (1993) Liposomal drug delivery systems: Clinical, diagnostic and ophthalmic applications. Drugs, 45, 15-28
12. Heath A. W. and Playfair J. H. L. (1990) Conjugation of interferon-gamma to antigen enhances its adjuvanticity. Immunology, 71, 454-456
13. Hirano K. and Hunt A., (1985) Lymphatic transport of liposome-encapsulated agents: Effects of liposome size following intra-peritoneal administration. J. Pharmaceut. Sci. 74, 915-921
14. Ho R. J. Y., Burke R. L., and Merigan T. C., (1992) Liposome-formulated interleukin-2 as an adjuvant of recombinant HSV glycoprotein gD for the treatment of recurrent genital HSV-2 in guinea pigs. Vaccine, 10, 209-213
15. Kirby C. and Gregoriadis G., (1984) Dehydration-rehydration vesicles: A simple method for high yield drug entrapment in liposomes. Biotechnology, 2, 980-984
16. Lederer J. A., Liou J. S., Todd M. D., Glimcher L. H. and Lichtman A. H., (1994) Regulation of cytokine gene expression in T helper cell subsets. J. Immunol., 152, 77-86
17. Malkovski M., Loveland B., North M., Asherson G. L., Gao L., Ward P. and Fiers W., (1987) Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes, Nature, 352, 262-265
18. Meuer S. C., Dumann H., Zum Buschenfelde K.-H. M. and Kohler H., (1989) Low-dose interleukin-2 induces systemic responses against HBsAg in immunodeficient non-responders to hepatitis B vaccination, The Lancet, 1, 15-18
19. O'Garra A. and Murphy K., (1994) Role of cytokines in determining T-lymphocyte function. Curr. Opinion Immunol., 6, 458-466
20. Reiter Z. and Rappaport B., (1993) Dual effects of cytokines in the regulation of MHC-unrestricted cell mediated cytotoxicity. Crit. Rev. Immunol., 13, 1-34
21. Senior J., Waters J. A. and Gregoriadis G., (1986) Antibody-coated liposomes: The role of non-specific antibody adsorption. FEBS Lett., 196, 54-58
22. Sencer S. F., Rich M. L., Katsanis E., Ochoa A. C. and Anderson P. M., (1991) Anti-tumor vaccine adjuvant effects of IL-2 liposomes in mice immunized against MCA-102 sarcoma. Eur. Cytokine Netw., 2, 311-318
23. Skalko N., Bouwstra J., Spies F. and Gregoriadis G., (1996) The effect of microfluidization of protein-coated liposomes on protein distribution on the surface of generated small vesicles. Biochim. Biophys. Acta, 1301, 249-254
24. Smith K. A., (1988) Interleukin-2: Inception, impact and implications. Science, 240, 1169-1176
25. Tan L. and Gregoriadis G., (1989) Effect of interleukin-2 on the immunoadjuvant action of liposomes. Biochem. Soc. Trans., 17, 693-694
26. Taylor C. E., Fauntleroy M. B., Stashsk P. W. and Baker P. J., (1991) Antigen-specific suppressor T cells respond to recombinant interleukin-2 and other lymphokines, Infect. Immunity, 59, 575-579
27. Velinova M., Reed N., Kirby C. and Gregoriadis G., (1995) Morphological observations on the fate of liposomes in the regional lymph nodes after footpad injection into rats. Biochim. Biophys. Acta, 1299, 207-215
28. Weinberg A. and Merigan T. C., (1988) Recombinant interleukin-2 as an adjuvant for vaccine-induced protection. Immunization of guinea pigs with Herpes simplex virus subunit vaccines,. J. Immunol., 140, 294-299