Syndromes associated with silicone breast implants: A clinical study and review

Journal of Nutritional and Environmental Medicine

Volumn 8, Issue 1, 1998, Pages 35-51

  Ericsson, Arthur Dale ^a  

^a Institute of Biologic Research   (United States)

Author keywords

Autoantibodies; Chronic inflammatory demyelinating polyneuropathy; Dermatomyositis; Fibromyalgia; Hashimoto's thyroiditis; Lupus erythematosis; Multiple sclerosis central demyelination; Polymyositis; Polyurethane; Rheumatoid arthritis; Scleroderma; Silica; Silicone; Silicone breast implants

Indexed keywords

SILICONE;

ARTICLE; BREAST ENDOPROSTHESIS; DEMYELINATION; FEMALE; HASHIMOTO DISEASE; HUMAN; PRIORITY JOURNAL; SYNDROME;

EID: 0031920849     PISSN: 13590847     EISSN: None     Source Type: Journal    
DOI: 10.1080/13590849862285     Document Type: Article

References (101)

1. Ostenmeyer B, Patten BM, Calkins DS. Adjuvant breast disease: a clinical evaluation of 100 symptomatic women with silicone breast implants or silicone fluid injections into the breast. Keio Med J 1994; 43: 79-87.
2. Lappe, M. 'Nonreactive' Chemicals lack Adverse Effects in Chemical Deception. San Francisco: Sierra Club Books, 1991.
3. Kessler DA, Merkatz RB, Schapiro R. A call for higher standards for breasts implants. JAMA 1993; 270: 2607-8.
4. Kessler DA. The basis of the FDA's decision of breast implants. N Engl J Med 1992; 326: 1713-15.
5. Kumagai Y, Shiokawa Y, Medsger TA, et al. Clinical spectrum of connective tissue disease after cosmetic surgery. Arthrit Rheumat 1984; 27: 1-12.
6. Kossovsky N, Heggers JP, Robson MC. The bioreactivity of silicone. Crit Rev Biocompat 1987; 3: 53-85.
7. Hausner R, Schoen FJ, Pierson KK. Foreign body reaction of silicone-gel in axillary lymph nodes after augmentation mammoplasty. Plastic Reconstruct Surg 1978; 62: 381-3.
8. Hilts PJ. Maker of implants says silicone-gel poses health risks. Houston Chron 1993; 20 March: 1-2.
9. Cronin T, Gerow F. Augmentation mammoplasty, a new natural fell prosthesis. In: Transactions of the Third International Congress of Plastic and Reconstructive Surgery. Amsterdam: Excerpta Medica, 1964; 41-2.
10. Brozerna SJ, Fenske NA, Cruse CW et al. Human adjuvant disease following augmentation mammoplasty. Arch Dermatol 1988; 124: 1383-6.
11. Cuellar M, et al. Silicone breast implants associated with musculo-skeletal manifestations. Clin Rheumat 1995; 14: 667-72.
12. Human Resources and Intergovernmental Relations Subcommittee of the Committee on Government Operations. The FDA's Regulation of Silicone Breast Implants. Washington, DC: US Government Printing Office, 1992.
13. Meggers JP. Kossovsky N, Parsons RW, et al. Biocompatability of silicone implants. Ann Plastic Surg 1983; 11: 38-45.
14. Jenny H, Smahe L. Clinicopathological correlation in pseudocapsule formation after breast augmentation. Aesth Plastic Surg 1981; 5: 63-8.
15. Kessel RWI, Monaco L, Marchisio MA. The specificity of the cytotoxic action of silica. A study in vitro. Br J Exp Pathol 1963; 44: 351-64.
16. Kaiser W, Beisenback W, Stuby U, et al. Human adjuvant disease: remission of silicone-induced autoimmune disease after explantation of breast augmentation. Ann Rheumat Dis 1990; 49: 937-8.
17. Batich C, DePalma D. Materials used in breast implants: silicones and polyurethanes. J Long-Term Effects Med Implants 1992; 1: 255-68.
18. Allison AC, Harrington JS, Birbeck M. An examination of the cytotoxic effects of silica on macrophages. J Exp Med 1966; 124: 141-53.
19. Argenta LC. Migration of silicone gel into breast parenchyma following mammary prosthesis rupture. Aesth Plastic Surg 1983; 7: 253-4.
20. Baldwin CM, Kaplan EN. Silicone induced human adjuvant disease. Ann Plastic Surg 1983; 10: 270-3.
21. Barker DE, Retsky MI, Schultz S. Bleeding of silicone from bag-gel breast implants and its clinical relation to fibrous capsule reaction. Plastic Reconstruct Surg 1978; 61: 836-41.
22. Batich C. Silicone degradation products. In: NIH Immunology of Silicones Workshop, 13-14 March 1995.
23. Garrido L, Detection of Silicone Migration with NMR. In: NIH Immunology of Silicones Workshop, 13-14 March 1995.
24. Garrido L, Pfleiderer B, Papisow M. et al. In vivo degradation of silicones. NRM 1993; 29: 839-43.
25. Goldblum RM, Pelley RP, O'Donell AA, et al. Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts. Lancet 1992; 340: 510-13.
26. Guthrie JL, McKinney RW. Determination of 2,4 and 2,6 diaminotoluene in flexible urethane foam. Anal Chem 1977; 49: 1676-80.
27. Harrison M. Adjuvancy and breast implants. Dow Corning Commun 1993; 4 March: 1-2.
28. Pernis B, Parnetto F. Adjuvant effect of silica (tridymite) on antibody production. Proc Soc Exp Biol Med 1962; 110: 390-2.
29. Lake RS, Radonovich H. Action of Polydimethylsiloxanes on the Reticuloendothelial System of Mice: Basic Cellular Interactions and Structure-Activity Relationship. Midland, MI: Dow Corning Corporation, Research Department, 1975.
30. Pfleiderer B, et al. Migration and biodegradation of free silicone from silicone gel-filled implants after long-term implantation. Magnet Res Med 1993; 30: 534-43.
31. Uber CL, McReynold RA. Immunotoxicology of silica. CRC Crit Rev Toxicol 1982; 10: 303-19.
32. Picha GJ, Goldstein JA, Stohr E. Natural-Y meme polyurethane versus smooth silicone: analysis of the soft-time interaction from 3 days to year in the rat animal model. Plastic Reconstruct Surg 1990; 85: 903-16.
33. Kossovsky N, Freiman S. Silicone breast implant pathology: clinical data and immunologic consequences. Arch Pathol Lab Med 1994; 118: 686-93.
34. Vodjani A, Campbell A, Brautbar N. Immune functional abnormalities in patients with clinical abnormalities and silicone breast implants. Toxicol Ind Health 1992; 8: 415-29.
35. Nain JO, Lanzafame RJ, van Oss CJ. The adjuvant effect of silicone gel on antibody formation in rats, Immunol Invest 1991; 22: 151-61.
36. Black DL. 2,4-TDA analysis with regards to PUF breast implants. Aegis Anal Lab Commun 1991; 4 June: 1-2 and 1993; August 11: 3-4.
37. Kossovsky N, Heggers JP, Robson MC. Experimental demonstration of the immunogenecity of silicone-protein complexes. J Biomed Mater Res 1987; 21: 1125-33.
38. Wolf C, et al. Chemical analysis of explanted breast implants. In: NIH Immunology of Silicones Workshop. 1995.
39. Bergman RB, van der Ende AE. Exudation of silicone through the envelope of gel filled breast prostheses: an in-vitro study. Br J Plastic Surg 1979; 32: 31-4.
40. Lust JA. The role of cytokines in the pathogenesis of monoclonal gammopathies. Mayo Clin Bull 1994; 69: 691-7.
41. Rodnan GP, Bendek TG, Medsger TA, et al. The association of progressive systemic sclerosis (scleroderma) with coal miners' pneumoconiosis and other forms of silicosis. Ann Intern Med 1966; 66: 323-8.
42. Swan S. Epidemiology of silicone-related disease. Sem Arthrit Rheumat 1994; 24 (Suppl 1): 38-43.
43. Tasher A, Broughton A. An ELISA method for detecting serum antibodies. Clin Chem 1993; 39: 1247-9.
44. Sergott TJ, Limoli JP, Baldwin CM et al. Human adjuvant disease; possible autoimmune disease after silicone implantation: a review of the literature, case studies and speculation for the future. Plastic Reconstruct Surg 1984; 78: 104-14.
45. Sahn EE, Garen PD, Silver RM et al. Scleroderma following augmentation mammoplasty. Arch Dermatol 1990; 126: 1198-202.
46. Schmidt GH. Mammary implant shell failure. Ann Plastic Surg 1980; 5: 369-71.
47. Chan SC, Birdsell DC, Gradeen CY. Detection of toluenediamines in the urine of a patient with polyurethane-covered breast implants. Clin Chem 1991; 37: 756-8.
48. Gayou R, Rudolph R. Capsular contraction around silicone mammary prostheses. Ann Plastic Surg 1979; 2: 62-71.
49. Capozzi A, Du Bou R, Pennisi VR. Distant migration of silicone-gel from a ruptured breast implant. Plastic Reconstuct Surg 1978; 62: 302-3.
50. Cocke WM Jr, Sampsom HW. Silicone bleed associated with double-lumen breast prostheses. Ann Surg 1979; 18: 524-6.
51. Ostermeyer B, Patten BM. Abnormal laboratory and histopathological findings in women with systemic disease and saline breast implants. Brain Pathol 1994; 15: 376-9.
52. Ostermeyer B, Patten BM. An atypical motor neuron disease syndrome in patients with breast implants. Can J Neurol Sci 1994; 1 (Suppl 2): 64-9.
53. Lee L, Ostermeyer B, Patten BM. An atypical chest pain syndrome in silicone breast implant patients. S Med J 1994: 87: 978-84.
54. Vargas A. Shedding of silicone particles form inflated breast implants. Plastic Reconstruct Surg 1979: 64: 252-3.
55. Travis WD, Balogh K, Abraham JJ. Silicone granulomas: report of three cases and review of the literature. Human Pathol 1985; 16: 19-26.
56. Miyoshi K, Miyamura T, Kobayashi Y. et al. Hypergammaglobulinemia by prolonged adjuivanticity in man. Disorders developed after augmentation mammoplasty. Jpn Med J 1964; 2122: 9-14.
57. Van Nunen SA, Gatenby PA, Basten A. Post-mammoplasty connective tissue disease. Arthrit Rheumat 1982; 25: 694-7.
58. Endo LP, Edwards NL, Longley G, et al. Silicone and rheumatic diseases. Sem Arthrit Rheumat 1987; 47: 112-18.
59. Varga J, Schumacher HR, Jimenez SA. Systemic sclerosis after augmentation mammoplasty with silicone implants. Ann Intern Med 1989; 149: 1194-6.
60. Varga J, Jimenez SA. Augmentation mummoplasty and scleroderma. Arch Dermatol 1990; 126: 1220-2.
61. Ericsson AD, DeGeorge J. The story of silicone. Explore 1996; 6: 13-16.
62. Fock KM, Feng PH, Tey BH. Autoimmune disease developing after augmentation mammoplasty: report of 3 cases. J Rheumat 1984; 11: 98-100.
63. Gelfand EW. Intervention in autoimmune disorders. Clin Immunol Immunopathol 1989; 53: S1-6.
64. Package Insert. Arlington, TX: Dow Corning Wright 1991.
65. Trachman H. Ilowite N, Levine J. Increased urinary NO and NO excretion in children breast fed by mothers with silicone implants (SI). Arthrit Rheumatol 1994; 37: s422 (1-8).
66. Truong LD, Cartwright J, Goodman D, et al. Silicone lymphadenopathy associated with augmentation mammoplasty. Morphologic features of nine cases. Am J Surg Pathol 1988; 12: 484-91.
67. Uretsky BF, O'Brien JJ, Courtiss EH, et al. Augmentation mammoplasty associated with a severe systemic illness. Ann Plastic Surg 1979; 3: 445-7.
68. Walsh FW, Solomon DA, Espinosa LR, et al. Human adjuvant disease. A cause of chylous effusions. Arch Intern Med 1989; 149: 1194-6.
69. Celli B, Texter S, Kovnut DM. Case report: adult respiratory distress syndrome following mammary augmentation. Am J Med Sci 1978; 275: 81-5.
70. Washington University Neuromuscular Clinical Laboratory Evaluation Publication, 1996.
71. Rechlin S. Neuroendocrine-Immune interactions. N Eng J Med 1993; 329: 1246-52.
72. Broughton A, Trasher JD. Auto-antibodies associated with silicone breast implants. Clin Chem 1993; 39: 1139-40.
73. Morse JH, Spiera H. Autoimmune disease immunoglobulin isotypes and lymphocyte subsets in 30 females with breast augmentation mammoplasty Arthrit Rheumat 1992; 35: 65-7.
74. Mancino D, Vuotto ML, Minucci M. Effects of a crystalline silica on antibody production to t-dependent and t-independent antigens in bald/c mice, Int Arch Allergy Appl Immunol 1984; 73: 10-13.
75. Bar-Meir E, Teuber SS, Lin HC, et al. Autoantibody profile of women with silicone breast implants. Arch Rheumat 1994; 37: s422 (9-12).
76. Bridges AJ, Conley C, Wang G, et al. A clinical immunological evaluation of women with silicone breast implants and symptoms of rheumatic disease. Ann Intern Med 1993; 118: 929-36.
77. Silver R Sahn EE, Allen JA. et al. Demonstration of silicon in slides of connective-tissue disease in patients with silicone-gel breast implants. Arch Dermatol 1993; 129: 63-8.
78. Silverman S, Mendoza M, Silver D, et al. Measurement of fatigue in patients with silicone breast implants (SBI) as compared to fibromyalgia (FM) and rheumatoid arthritis (RA). Arthrit Rheumat 1994; 37: S271, 4-6.
79. Love LA, Weiner SR, Vasey FB, et al. Clinical and immunogenetic features of women who developed myositis after silicone implants. Arthrit Rheumat 1992; 35: 46-8.
80. Freundlich B, Tomaszewski J, Callegari P. A Sjogren's-like syndrome in women with silicone-gel breast implants. Arthrit Rheumat 1992; 35: 67-9.
81. Tenenbaum SA, Silveira LH, Martinez-Osuma P, et al. Identification of a novel auto-antigen recognized in silicone associated connective tissue disease. Arthrit Rheumat 1992; 35: 73-5.
82. Ostermeyer B, Patten BM. An MS-like syndrome in women with silicone breast implants or silicone fluid injections in breast. Neurology 1994; 44: A158: 37-44.
83. Ostermeyer B, and Patten BM. Human adjuvant disease presenting as multiple sclerosis-like syndrome. S Med J 1996; 89: 179-88.
84. Levine J, Ilowite N. Scleroderma-like esophageal disease in children breast-fed by mothers with silicone breast implants. JAMA 1994; 271: 213-16.
85. Gutierrez FJ, Espinosa LR. Progressive systemic sclerosis complicated by severe hypertension; reversal after silicone implant removal. Am J Med 1990; 89: 390-2.
86. Young, V. et al. HLA typing in women with breast implants. Plastic Reconstruct Surg 1995; 96: 1497-519.
87. Jekel J, et al. Epidemiology biostatistics and preventive medicine. Philadelphia, PA: W. B. Saunders, 1996.
88. Rosenberg N. The neuromythology of silicone breast implants. Neurology 1996; 310: 308-14.
89. Weisman MH, Vecchione TR, Albert D, et al. Connective tissue disease following breast augmentation: a preliminary test of the human adjuvant hypothesis. Plast Reconstr Surg 1988; 82: 626-30.
90. Bright RA, Jeng LL, Moore RM. National survey of self-reported breast implants; 1988 estimates. J Long-Term Effects Med Implants 1993; 3: 81-9.
91. Okano V, Nishikai M, Sato A. Scleroderma, primary biliary cirrhosis and Sjogren's syndrome after cosmetic breast augmentation with silicone injection: a case report of possible human adjuvant disease. Ann Rheumat Dis 1984; 43: 520-1.
92. Oxelius V. Immunoglobulin G subclasses and human disease. Am J Med 1984; 4: 7-18.
93. Kumagai Y, Abe C, and Shiokawa Y. Scleroderma after cosmetic surgery. Arthrit Rheumat 1979; 22: 532-7.
94. Spiera H. Scleroderma after silicone augmentation mammoplasty. JAMA 1988; 260: 236-8.
95. DeCamara DL, Sheridan JM, Kammer BA. Rupture and aging of silicone gel breast implants. Plastic Reconstruct Surg 1993; 91: 828-34.
96. Cook RR, Delongchamp RR, Woodbury M. et al. Breast implant prevalence. Dow Corning Commun 1993; 17 March: 2-3.
97. Spiera H, Kerr L. Scleroderma following silicone implantation: a cumulative experience of twelve cases. Arch Rheumat 1992; 35: 68-72.
98. Koeger C, Alxaix D, Rozenberg S, et al. Silica-induced connective tissue diseases do still occur. Arthrit Rheumat 1993; 35: 34-7.
99. Jordan S. Intravenous gamma globulin therapy in systemic lupus erythematosis and immune complex disease. Clin Immunol Immunopathol 1989; 53: 164-9.
100. Dwyer JM. Intravenous therapy with gamma globulin. Adv Intern Med 1987; 32: 111-36.
101. Barrett J. Textbook of Immunology. St Louis: Mosby Company, 1988.