Injection of T-cell receptor peptide reduces immunosenescence in aged C57BL/6 mice

Immunology

Volumn 93, Issue 4, 1998, Pages 462-468

  Liang, B ^a,c   Zhang, Z ^a   Inserra, P ^a   Jiang, S ^a   Lee, J ^a   Garza, A ^b   Marchalonis, J J ^b   Watson, R R ^a,b  

^a Arizona Prevention Center   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; RECEPTOR ANTIBODY; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNE DEFICIENCY; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; SPLEEN CELL; T LYMPHOCYTE;

AGING; ANIMALS; AUTOANTIBODIES; BODY WEIGHT; CELL DIVISION; CYTOKINES; FEMALE; HUMANS; IMMUNE TOLERANCE; MICE; MICE, INBRED C57BL; MITOGENS; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SPLEEN;

EID: 0031920794     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1998.00470.x     Document Type: Article

References (18)

1. EENGWERDA C.R., HANDWERGER B. S. & FOX B.S. (1996) An age-related decrease in rescue from T cell death following costimulation mediated by CD28. Cellul Immunol 170, 141.
2. GYETKO M.R. & TOEWS, GB. (1993) Immunology of the aging lung. Clinics in Chest Medicine 14, 379.
3. DEHGHANPISHEH K., HUANG D., SCHUTER S.F. et al. (1995) Production of IgG autoantibodies to TCRs in mice infected with the retrovirus LP-BM5. Int Immunol 7, 31.
4. WATSON R.R., WANG J.Y., DEHGHANPISHEH K. et al. (1995) T cell receptor Vβ complementarity-determining region 1 peptide administration moderates immune dysfunction and cytokine dysregulation induced by murine retrovirus infection. J Immunol 155, 2282.
5. MARCHALONIS J.J., KAYMAZ H., DEDEOGLU F. et al (1992) Human autoantibodies reactive with synthetic autoantigens from T-cell receptor β chain. Proc Natl Acad Sci USA 89, 3325.
6. KAYMAZ H., DEDEOGLU F., SCHLUTER S.F. et al. (1993) Reactions of anti-immunoglobulin sera with synthetic T-cell receptor peptides: implications for the three-dimensional structure and function of the TCR β chain. Int Immunol 5, 491.
7. TOYONAGA B. & MAK T.W. (1987) Genes of the T-cell antigen receptor in normal and malignant T-cells. Ann Rev Immunol 5, 585
8. FENG D.F. & DOOLITTLE R.F. (1987) Progressive sequence alignment as a prerequisite to correct phylogenetic trees. J Mol Evol 25, 351.
9. LIANG B., ARDESTANI S., MARCHALONIS J.J. et al. (1996) T-cell-receptor dose and the time of treatment during murine retrovirus infection for maintenance of immune function. Immunology 87, 198.
10. OFFNER H., HASHIM G.A. & VANDENBARK A.A. (1991) T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science 251(4992), 430.
11. HALLGREN, H.M., BUCKLEY C.E. 3RD., GILBERTSEN V.A. et al. (1973) Lymphocyte phythohemagglutinin responsiveness, immunoglobulins and autoantibodies in aging humans. J Immunol 111, 1101.
12. MILLER R.A. (1991) Aging and immune function. Int Rev Cytol 124, 187.
13. + T cells from young and old mice. J Immunol 150, 3602.
14. + cells and cell subsets from young and old mice. Cellul Immunol 154, 264.
15. SIMONS R.J. & REYNOLDS H.Y. (1990) Altered immune status in the elderly. Semin Resp Infect 5, 251.
16. DITTEL R.N., SANT'ANGELO D.B. & JANEWAY C.A. JR. (1997) Peptide antagonists inhibit proliferation and the production of IL-4 and/or IFN-gamma in T helper 1, T helper 2 and T helper 0 clones bearing the same TCR. J Immunol 158, 4065.
17. BOLDT-HOULE D.M., JAMIESON B.D., ALDROVANDI G.M. et al. (1997) Loss of T cell receptor Vβ repertiores in HIV type 1-infected SCID-hu mice. AIDS Res Human Retrovirus 13, 125.
18. WARD E.S. & QADRI A. (1997) Biophysical and structural studies of TCRs and ligands: implications for T cell signaling. Curr Opin Immunol 9, 97.