Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by immunohistochemistry

British Journal of Cancer

Volumn 77, Issue 9, 1998, Pages 1460-1468

  Marsh, K L ^a   Varley, J M ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

Breast tumours; Cell cycle; Immunohistochemistry

Indexed keywords

CYCLIN D1; PROTEIN P16;

ARTICLE; BREAST CARCINOMA; CARCINOMA IN SITU; CELL CYCLE; CLINICAL ARTICLE; FEMALE; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 0031920711     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.240     Document Type: Article

References (42)

1. Atadja P, Wong H, Veillete C and Riabowol K (1995) Overexpression of cyclin D1 blocks proliferation of normal diploid fibroblasts. Exp Cell Res 217: 205-216
2. Bartkova J, Lukas J, Muller H, Lutzhoft D, Strauss M and Bartek J (1994) Cyclin D1 protein expression and function in human breast cancer. Int J Cancer 57: 353-361
3. Bartkova J, Lukas J, Strauss M and Bartek J (1995) Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis. Oncogene 10: 775-778
4. Bates S, Parry D, Bonetta L, Vousden K, Dickson C and Peters G (1994) Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein. Oncogene 9: 1633-1640
5. Berns EMJJ, De Klein A, Van Putten WLU, Van Staveren IL, Bootsma A, Klijn JGM and Foekens JA (1995) Association between RB-1 gene alterations and factors of favourable prognosis in human breast cancer, without effect on survival. Int J Cancer 64: 140-145
6. Betticher DC, Thatcher N, Altermatt HJ, Hoban P, Ryder WDJ and Heighway J (1995) Alternate splicing produces a novel cyclin D1 transcript. Oncogen 11: 1005-1011
7. Betticher DC, Heighway J, Hasleton PS, Altermatt HJ, Ryder WDJ, Cerny T and Thatcher N (1996) Prognostic significance of CCNDI (cyclin D1) overexpression in primary resected non-small-cell lung cancer. Br J Cancer 73: 294-300
8. Borg A, Zhang Q-X, Alm P, Olsson H and Sellberg G (1992) The retinoblastoma gene in breast cancer: allele loss is not correlated with loss of gene protein expression. Cancer Res 52: 2991-2994
9. Brenner AJ and Aldaz CM (1995) Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells. Cancer Res 55: 2892-2895
10. Bringuier PP, Tamimi Y, Schuuring E and Schalken J (1996) Expression of cyclin D1 and EMS1 in bladder tumours; relationship with chromosome 11q13 amplification. Oncogene 12: 1747-1753
11. Buckley MF, Sweeney KJE, Hamilton JA, Sini RL, Manning DL, Nicholson RI, Defazio A, Watts CKW, Musgrove EA and Sutherland RL (1993) Expression and amplification of cyclin genes in human breast cancer. Oncogene 8: 2127-2133
12. Fantl V, Richards MA, Smith R, Lammie GA, Johnstone G, Allen D, Gregory W, Peters G, Dickson C and Barnes DM (1990) Gene amplification on chromosome band 11q13 and oestrogen receptor status in breast cancer. Eur J Cancer 26: 423-429
13. Geradts J, Hu S-X, Lincoln CE, Benedict WF and Xu H-J (1994) Aberrant RB gene expression in routinely processed, archival tumour tissues determined by three different anti-RB antibodies. Int J Cancer 58: 161-167
14. Gillett C, Smith P, Gregory W, Richards M, Millis R and Peters G (1996) Cyclin D1 and prognosis in human breast cancer. Int J Cancer 69: 92-99
15. Han EK-H, Sgambato A, Jiang W, Zhang Y-J, Santella RM, Doki Y, Cacace AM, Schieren I and Weinstein IB (1995) Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth. Oncogene 10: 953-961
16. Harbour JW, Lai S-L, Whang-Peng J, Gazdar AF, Minna JD and Kaye FJ (1988) Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 241: 353-356
17. INK4 or retinoblastoma protein (pRb). or amplification-associated overexpression of edk4 is observed in distinct subsets of malignant glial tumours and cell lines. Cancer Res 55: 4833-4836
18. Kranenburg O, Van Der Eb AJ and Zantema A (1996) Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J 15: 46-54
19. Lammie GA, Fantl V, Smith R, Schuuring E, Brookes S, Michalides R, Dickson C, Arnold A and Peters G (1991) D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1. Oncogene 6: 439-444
20. Li Y, Nichols MA, Shay JW and Xiong Y (1994) Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRB. Cancer Res 54: 6078-6082
21. Lukas J, Pagano M, Staskovie Z, Draetta G and Bartek J (1994) Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene 9: 707-718
22. 1 control. Cancer Res 55: 4818-4823
23. Lukas J, Bartkova J, Welcker M, Petersen OW and Peters G (1995b) Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types. Oncogene 10: 2125-2134
24. Michalides R, Hageman P, Van Tinteren H, Houben L, Weintjens E, Klompmaker R and Peterse J (1996) A clinicopathological study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer. Br J Cancer 73: 728-734
25. Muller H, Lukas J, Schneider A, Warthoe P, Bartek J, Eilers M and Strauss M (1994) Cyclin D1 expression is regulated by the retinoblastoma protein. Proc Natl Acad Sci USA 91: 2945-2949
26. Nakagawa H, Zukerberg L, Togawa K, Meltzer SJ, Nishihara T and Rustgi AK (1995) Human cyclin D1 oncogene and oesophageal squamous cell careinoma. Cancer 76: 541-549
27. Nishida N, Fukudu Y, Komeda T, Kita R, Sando T, Furukawa M, Amenomori M, Shibagaki I, Nakao K, Ikenaga M and Ishizaki K (1994) Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res 54: 3107-3110
28. INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB. Oncogene 9: 3375-3378
29. Reed JA, Loganzo F, Shea CR, Walker GJ, Flores JF, Glendening JM, Bogdany JK, Shiel MJ, Haluska FG, Fountain JW and Albino AP (1995) Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumour suppressor gene in melanocytic lesions correlates with invasive stage tumour progression. Cancer Res 55: 2713-2718
30. Sakaguchi M, Fujii Y, Hirabayashi H, Yoon H-E, Komoto Y, Oue T, Kusafuka T. Okada A and Matsuda H (1996) Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: an immunohistochemical study. Int J Cancer 65: 442-445
31. Schuuring E, Verhoeven K, Van Tinteren H, Peterse JL, Nunnink B, Thunnissen FBJM, Devilee P, Cornelisse CJ, Van de Vijver MJ, Mooi WJ and Michalides RJAM (1992) Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer. Cancer Res 52: 5229-5234
32. INK4 expression in primary lung cancers and cell lines. Cancer Res 55: 505-509
33. Sicinski P, Donaher JL, Parker SB, Li T, Fazeli A, Gardner H, Haslam SZ, Bronson RT, Elledge SJ and Weinberg RA (1995) Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82: 621-630
34. Sonoda Y, Yoshimoto T and Sekiya T (1995) Homozygous deletion of the MTSI/p16 and MTS2/p15 genes and amplification of the CDK4 gene in glioma. Oncogene 11: 2145-2149
35. Ueki K, Ono Y, Henson JW, Efird JT, Von Diemling A and Louis DN (1996) CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res 56: 150-153
36. Varley JM, Armour J, Swallow JE, Jeffreys AJ, Ponder BAJ, Tang A, Fung Y-KT, Brammar WJ and Walker RA (1989) The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours. Oncogene 4: 725-729
37. Wadayama B, Toguchida J, Shimizu T, Ishizaki K, Sasaki MS, Kotoura Y and Yamamuro T (1994) Mutation spectrum of the retinoblastoma gene in osteosarcomas. Cancer Res 54: 3042-3048
38. Wang Y and Becker D (1996) Differential expression of the cyclin-dependent kinase inhibitors p16 and p21 in the human melanocytic system. Oncogene 12: 1069-1075
39. Weinstat-Saslow D, Merino MJ, Manrow RE, Lawrence JA, Bluth RF. Wittenbel KD, Simpson JF, Page DL and Steeg PS (1995) Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions. Nature Med 1: 1257-1260
40. Welcker M, Lukas J, Strauss M and Bartek J (1996) Enhanced protein stability: a novel mechanism of D-type cyclin over-abundance identified in human sarcoma cells. Oncogene 13: 419-425
41. Ink4) in human breast carcinomas. Cancer Res 54: 5262-5264
42. Yeager T, Stadler W, Belair C, Puthenveettil J, Olopade O and Reznikoff C (1995) Increased p16 levels correlate with pRb alterations in human urothelial cells. Cancer Res 55: 493-497