Expression of mdm2 and p53 in epithelial neoplasms of the colorectum

Journal of Clinical Pathology - Molecular Pathology

Volumn 51, Issue 1, 1998, Pages 26-29

  Hao, X P ^a   Gunther T ^b   Roessner, A ^b   Price, A B ^a   Talbot, I C ^a  

^a ST MARK S HOSPITAL   (United Kingdom)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Colorectal carcinoma; mdm2; p53

Indexed keywords

PROTEIN P53;

ARTICLE; COLON ADENOMA; COLON CARCINOGENESIS; COLORECTAL CANCER; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; ONCOGENE; PRIORITY JOURNAL;

EID: 0031920429     PISSN: 13668714     EISSN: None     Source Type: Journal    
DOI: 10.1136/mp.51.1.26     Document Type: Article

References (24)

1. Cahilly-Snyder L, Yang-Feng T, Francke, U, et al. Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somat Cell Mol Genet 1987;13:235-44.
2. Fakharzadeh SS, Trusko SP, George DL. Tumourigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumour cell line. EMBO J 1991;10:1565-9.
3. Momand J, Zambetti GP, Olson DC, et al. The mdm2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992;69: 1237-45.
4. Montes de Oca Luna R, Wager DS, Lozano G. Rescue of early embryonic lethality in mdm-2-deficient mice by deletion of p53. Nature 1995;378:203-6.
5. Jones SN, Roe AE, Donehower LA, et al. Rescue of embryonic lethality in mdm-2-deficient mice by absence of p53. Nature 1995;378:206-8.
6. Martin K, Trouche D, Hagemeier C, et al. Stimulation of E2F1/DP1 transcriptional activity by mdm2 oncoprotein. Nature 1995;375:691-4.
7. Xiao ZX, Chen JD, Levine AJ, et al. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 1995;375:694-8.
8. Oliner GD, Kinzler KW, Meltzer PS, et al. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 1992;358:80-3.
9. Cordon-Cardo C, Latres E, Drobnjak M, et al. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res 1994;54:794-9.
10. Reifenberger G, Liu L, Ichimura K, et al. Amplification and overexpression of mdm2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res 1993;53: 2736-9.
11. Watanabe T, Hotta T, Ichikawa A, et al. The mdm2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin. Blood 1994;84: 3158-65.
12. Martinez JC, Mateo M, Sánchez-beato M, et al. MDM2 expression in lymphoid cells and reactive and neoplastic lymphoid tissue. Comparative study with p53 expression. J Pathol 1995;177:27-34.
13. Marchetti A, Buttitta F, Girlando S, et al. mdm2 gene alterations and mdm2 protein expression in breast carcinomas. J Pathol 1995;175:31-8.
14. Gorgoulis VG, Zoumpourlis V, Rassidakis GZ, et al. A molecular and immunohistochemical study of the mdm2 protein isoforms and p53 gene product in bronchogenic carcinomas. J Pathol 1996;180:129-37.
15. Ladanyi M, Cha C, Lewis R, et al. MDM2 gene amplification in metastatic usteosarcoma. Cancer Res 1993; 53:16-18.
16. Kessis TD, Slebos RJ, Han SM, et al. p53 gene mutations and mdm2 amplification are uncommon in primary carcinomas of the uterine cervix. Am J Pathol 1993;143:1398-405.
17. Fearon ER, Vogelstein B. A genetic model for colorectal tumourigenesis. Cell 1990;61:759-67.
18. Pignatelli M, Stamp GWH, Kafiri F, et al. Overexpression of p53 nuclear oncoprotein in colorectal adenomas. Int J Cancer 1992;50:683-8.
19. Sinicrope FA, Ruan SB, Cleary KR, et al. bcl-2 and p53 oncoprotein expression during colorectal tumourigenesis. Cancer Res 1995;55:237-41.
20. Olson D, Marechal V, Momand J, et al. Identification and characterisation of multiple mdm2 proteins and mdm2 p53 protein complexes. Oncogene 1993;8:2353-60.
21. Haupt Y, Maya R, Kazaz A, et al. Mdm2 promotes the rapid degradation of p53. Nature 1997;387:296-9.
22. Kubbutat MHG, Jones SN, Vousden KH. Regulation of p53 stability by mdm2. Nature 1997:387:299-303.
23. Chen J, Wu X, Lin J, et al. mdm2 inhibits the G1 arrest and apoptosis functions of the p53 tumour suppressor protein. Mol Cell Biol 1996;16:2445-52.
24. Momand J, Zambetti GP. Analysis of the proportion of p53 bound to mdm-2 in cells with defined growth characteristics. Oncogene 1996;12:2279-89.