In general, antimicrobial activities of 14-membered macrolides were higher than those of 16-membered macrolides. The antimicrobial activities of 14-membered macrolides were in the order of clarithromycin (CAM), erythromycin (EM), roxithromycin (RXM). Among 16-membered macrolides, rokitamycin (RKM) was the most potent, josamycin (JM) was next potent followed by midecamycin (MDM). More numbers of highly-resistant strain of > 100 μg/ml were recognized in 14-membered macrolides than in 16-membered macrorides.
2
33749335964
Most of S. pyogenes (group A) strains were distributed in the susceptible range and almost none was found in the resistant range.
Most of S. pyogenes (group A) strains were distributed in the susceptible range and almost none was found in the resistant range.
3
84865934165
S. pneumonias strains were distributed widely from the susceptible range to the highly resistant range, and as high as 37.1% fell into the high resistance of > 100 μg/ml range.
S. pneumonias strains were distributed widely from the susceptible range to the highly resistant range, and as high as 37.1% fell into the high resistance of > 100 μg/ml range.
4
33749347685
note
Against Peptostreptococcus spp. and MRSA, 16-membered macrolides were more effective than 14-membered macrorlides, and their antibacterial activities were in the order of RKM, JM, MDM. Ratio of high-resistant strains of > 100 μg/ml against 14-membered macrolides was much higher than that against 16-membered macrolies.
5
33749329589
note
Most of M. (B.) calarrhalis strains were distributed in the susceptible range of ≦ 1.56 μg/ml, and most of H. influenzas strains were distributed within the moderately resistant and the resistant ranges.
6
33749315913
In M. (B.) calarrhalis and H. influenzas, no correlation between macrolide resistance and beta-lactamase production was recognized.
In M. (B.) calarrhalis and H. influenzas, no correlation between macrolide resistance and beta-lactamase production was recognized.
7
33749330798
Most of C. jejuni strains were susceptible to all macrolides used in this study.
Most of C. jejuni strains were susceptible to all macrolides used in this study.
(1988)Chemotherapy, vol.36, Issue.3 SUPPL., pp. 1-33
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0028860018
In vitro activities of a streptogramin (RP59500), three macrolides, and an azalide against four respiratory tract pathogens. Antimicrob
A. L. BARRY & P. C. Fucus: In vitro activities of a streptogramin (RP59500), three macrolides, and an azalide against four respiratory tract pathogens. Antimicrob. Agents Chemother. 39: 238-240, 1995
