Humoral immune response to p53 in malignant glioma

Journal of Neurology

Volumn 245, Issue 3, 1998, Pages 169-172

  Weller, Michael ^a   Bornemann, Antje ^b   Ständer, Marko ^a   Schabet, Martin ^a   Dichgans, Johannes ^a   Meyermann, Richard ^b  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Antibody; Glioma; Immune; p53; Transforming growth factor (TGF )

Indexed keywords

ANTIBODY; PROTEIN P53; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; ANTIBODY BLOOD LEVEL; ARTICLE; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; FEMALE; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HUMORAL IMMUNITY; LEPTOMENINX; MALE; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; AGED; AUTOANTIBODIES; BRAIN NEOPLASMS; FEMALE; GLIOMA; HUMANS; MALE; MIDDLE AGED; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031919187     PISSN: 03405354     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004150050199     Document Type: Article

References (16)

1. Angelopoulou K, Diamandis EP, Sutherland DJA, Kellen JA, Bunting PS (1994) Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers. Int J Cancer 58:480-487
2. Bögler O, Huang HJS, Kleihues P, Cavenee WK (1995) The p53 gene and its role in brain tumors. Glia 15:308-327
3. Constam DB, Philipp J, Malipiero UV, Ten Dijke P, Schachner M, Fontana A (1992) Differential expression of transforming growth factor-β1, -β2, and -β3 by glioblastoma cells, astrocytes, and microglia. J Immunol 148:1404-1410
4. Crawford LV, Pim DC, Bulbrook RD (1982) Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer. Int J Cancer 30:403-408
5. Greenblatt MS, Bennett, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855-4878
6. Levesque MA, D'Costa M, Diamandis EP (1996) p53 protein is absent from the serum of patients with lung cancer. Br J Cancer 74:1434-1440
7. Lubin R, Schlichtholz B, Bengoufa D, Zalcman G, Trédaniel J, Hirsch A, Caron de Fromentel C, Preudhomme C, Fenaux P, Fournier G, Mangin P, Laurent-Puig P, Pelletier G, Schlumberger M, Desgrandchamps F, Le Duc A, Peyrat JP, Janin N, Bressac B, Soussi T (1993) Analysis of p53 antibodies in patients with various cancers define B-cell epitopes of human p53: distribution on primary structure and exposure on protein surface. Cancer Res 53:5872-5876
8. Lubin R, Schlichtholz B, Teillaud JL, Garay E, Bussel A, Wild CP, Soussi T (1995) p53 antibodies in patients with various types of cancer: assay, identification, and characterization. Clin Cancer Res 1:1463-1469
9. Mayordomo JI, Loftus DJ, Sakamoto H, De Cesare CM, Appasamy PM, Lotze MT, Storkus WJ, Appella E, De Leo AB (1996) Therapy of murine tumors with p53 wild-type and mutant sequence peptide-hased vaccines. J Exp Med 183:1357-1365
10. Roth J, Dittmer D, Rea D, Tartaglia J, Paoletti E, Levine AJ (1996) p53 as a target for cancer vaccines: recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge. Proc Natl Acad Sci USA 93:4781-4786
11. Ryder SD, Rizzi PM, Volkmann M, Metivier E, Pereira LMMB, Galle PR, Naoumov NV, Zentgraf H, Williams R (1996) Use of specific ELISA for the detection of antibodies directed against p53 protein in patients with hepatocellular carcinoma. J Clin Pathol 49:295-299
12. Soussi T (1996) The humoral response to the tumor-suppressor gene-product p53 in human cancer: implications for diagnosis and therapy. Immunol Today 17:354-356
13. Van Meir EG, Kikuchi T, Tada T, Li H, Diserens AC, Wojcik BE, Huang HJS, Friedmann T, De Tribolet N, Cavenee WK (1994) Analysis of the p53 gene and its expression in human glioblastoma cells. Cancer Res 54:649-652
14. Weller M, Fontana A (1995) The failure of current immunotherapy for malignant glioma. Tumor-derived TGF-β, T cell apoptosis, and the immune privilege of the brain. Brain Res Rev 21:128-151
15. Weller M, Frei K, Groscurth P, Krammer PH, Yonekawa Y, Fontana A (1994) Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human malignant glionia cells. Induction and modulation of sensitivity by cytokines. J Clin Invest 94:954-964
16. Weller M, Winter S, Schmidt C, Esser P, Fontana A, Dichgans J, Groscurth P (1997) Topoisomerase I inhibitors for human malignant glioma. Differential modulation of p53, p21, bax and bcl-2 expression and of CD95-mediated apoptosis by camptothecin and β-lapachone. Int J Cancer 73:707-714