Cytogenetics of leukemia

Cancer Investigation

Volumn 16, Issue 2, 1998, Pages 127-134

  Heerema, Nyla A ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LEUKEMIA; BURKITT LYMPHOMA; CHRONIC MYELOID LEUKEMIA; HUMAN; LEUKEMIA; LEUKEMOGENESIS; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; REVIEW; TRISOMY 8;

EID: 0031919114     PISSN: 07357907     EISSN: None     Source Type: Journal    
DOI: 10.3109/07357909809039765     Document Type: Review

References (137)

1. Heim S, Mitelman F: Primary chromosome abnormalities in human neoplasia. Adv Cancer Res 52:1-43, 1989.
2. Heim S, Mitelman F: Secondary chromosome aberrations in the acute leukemias. Cancer Genet Cytogenet 22:331-338, 1986.
3. Rowley JD: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 243:290-293, 1973.
4. De Braekeleer M: Variant Philadelphia translocations in chronic myeloid leukemia. Cytogenet Cell Genet 44:215-222, 1987.
5. van der Plas DC, Grosveld G, Hagemeijer A: Review of clinical, cytogenetic, and molecular aspects of Ph-negative CML. Cancer Genet Cytogenet 52:143-156, 1991.
6. Kantarjian HM, Deisseroth A, Kurzrock R, et al: Chronic myelogenous leukemia: A concise update. Blood 82:691-703, 1993.
7. First International Workshop on Chromosomes in Leukaemia 1977: Chromosomes in Ph′-positive chronic granulocytic leukaemia. Br J Haematol 39:305-310, 1978.
8. Groffen J, Stephenson JR, Heisterkamp N, et al: Philadelphia chromosomal breakpoints are clustered with a limited region, bcr, on chromosome 22. Cell 36:93-99, 1984.
9. Heisterkamp N, Stam K, Groffen J, et al: Structural organization of the bcr gene and its role in the Ph' translocation. Nature 315:758-761, 1985.
10. Shtivelman E, Lifshitz B, Gale RP, et al: Fused transcripts of abl and bcr genes in chronic myelogenous leukaemia. Nature 315:550-554, 1985.
11. Grosveld G, Verwoerd T, van Agthoven T, et al: The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript. J Mol Cell Biol 6:607-616, 1986.
12. Gale RP, Goldman JM: Rapid progress in chronic myelogenous leukemia. Leukemia 2:321-324, 1988.
13. 1negative chronic granulocytic leukemia: A nonentity. Am J Clin Pathol 85:186-193, 1986.
14. Yunis JJ, Lobell M, Arnesen MA, et al: Refined chromosome study helps define prognostic subgroups in most patients with primary myelodysplastic syndrome and acute myelogenous leukaemia. Br J Haematol 68:189-194, 1988.
15. Fourth International Workshop on Chromosomes in Leukemia: A prospective study of acute nonlymphocytic leukemia. Cancer Genet Cytogenet 11:249-360, 1984.
16. Marosi C, Köller U, Koller-Weber E, et al: Prognostic impact of karyotype and immunologic phenotype in 125 adult patients with de novo AML. Cancer Genet Cytogenet 61:14-25, 1992.
17. Heim S, Bekassy AN, Garzicz S, et al: Bone marrow karyotypes in 94 children with acute leukemia. Eur J Haematol 44:227, 1990.
18. Heinonen K, Rautonen J, Siimes MA, et al: Cytogenetic study of 105 children with acute lymphoblastic leukemia. Eur J Haematol 41:237-242, 1988.
19. Prigogina EL, Puchkova GP, Mayakova SA: Nonrandom chromosomal abnormalities in acute lymphoblastic leukemia of childhood. Cancer Genet Cytogenet 32:183-203, 1988.
20. Third International Workshop on Chromosomes in Leukemia, 1980: Clinical significance of chromosomal abnormalities in acute lymphoblastic leukemia. Cancer Genet Cytogenet 4:111-137, 1981.
21. Group Francais de Cytogenetique Hematologique: Collaborative study of karyotypes in childhood acute lymphoblastic leukemias. Leukemia 7:10-19, 1993.
22. Bennett JM, Catovsky D, Daniel MT, et al: Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group. Ann Intern Med 103:626-629, 1985.
23. Heim S: Numerical chromosome aberrations in human neoplasia. Cancer Genet Cytogenet 22:99-108, 1986.
24. Hagemeijer A, Hählen K, Abels J: Cytogenetic follow-up of patients with nonlymphocytic leukemia. II. Acute nonlymphocytic leukemia. Cancer Genet Cytogenet 3:109-124, 1981.
25. Fenaux P, Preudhomme C, Laï JL, et al: Cytogenetics and their prognostic value in de novo acute myeloid leukaemia: a report on 283 cases. Br J Haematol 73:61-67, 1989.
26. Berger R, Flandrin G, Bernheim A, et al: Cytogenetic studies on 519 consecutive de novo acute nonlymphocytic leukemias. Cancer Genet Cytogenet 29:9-21, 1987.
27. Mitelman F, Heim S: Quantitative acute leukemia cytogenetics. Genes Chromos Cancer 5:57-66, 1992.
28. Heim S, Mitelman F. Cancer Cytogenetics, 2nd ed, New York, Wiley-Liss, 1995.
29. Schiffer CA, Lee EJ, Tomiyasu T, et al: Prognostic impact of Cytogenetic abnormalities in patients with de novo acute nonlymphocytic leukemia. Blood 73:263-270, 1989.
30. Dewald GW, Schad CR, Lilla VC, et al: Frequency and photographs of HGM11 chromosome anomalies in bone marrow samples from 3,996 patients with malignant hematologic neoplasms. Cancer Genet Cytogenet 68:60-69, 1993.
31. Swansbury GJ, Lawler SD, Alimena G, et al: Long-term survival in acute myelogenous leukemia: A second follow-up of the Fourth International Workshop on Chromosomes in Leukemia. Cancer Genet Cytogenet 73:1-7, 1994.
32. Cortes JE, Kantarjian H, O'Brien S, et al: Clinical and prognostic significance of trisomy 21 in adult patients with acute myelogenous leukemia and myelodysplastic syndromes. Leukemia 9:115-117, 1995.
33. Mitelman F, Kaneko Y, Trent J: Report of the committee on chromosome changes in neoplasia. Cytogenet Cell Genet 58:1053-1079, 1991.
34. Sreekantaiah C, Baer MR, Morgan S, et al: Trisomy/tetrasomy 13 in seven cases of acute leukemia. Leukemia 4:781-785, 1990.
35. Cuneo A, Ferrant A, Michaux JL, et al: Cytogenetic profile of minimally differentiated (FAB M0) acute myeloid leukemia: correlation with clinicobiologic findings. Blood 85:3688-3694, 1995.
36. Le Beau MM, Albain KS, Larson RA, et al: Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7. J Clin Oncol 4:325-345, 1986.
37. Pedersen-Bjergaard J, Philip P, Larsen SO, et al: Therapy-related myelodysplasia and acute myeloid leukemia. Cytogenetic characteristics of 115 consecutive cases and risk in seven cohorts of patients treated intensively for malignant diseases in the Copenhagen series. Leukemia 12:1975-1986, 1993.
38. Samuels BL, Larson RA, Le Beau MM, et al: Specific chromosomal abnormalities in acute nonlymphocytic leukemia correlate with drug susceptibility in vivo. Leukemia 2:79-83, 1988.
39. Nimer SD, Golde DW: The 5q- abnormality. Blood 70:1705-1712, 1987.
40. Boultwood J, Lewis S, Wainscoat JS: The 5q- syndrome. Blood 84:3253-3260, 1994.
41. Grignani F, Fagioli M, Alcalay M, et al: Acute promyelocytic leukemia: from genetics to treatment. Blood 83:10-25, 1994.
42. Licht JD, Chomienne C, Goy A, et al: Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17). Blood 85:1083-1094, 1995.
43. Petkovic I, Konja J, Nakic M: Cytogenetic analysis in children with acute nonlymphocytic leukemia. Cancer Genet Cytogenet 58:155-159, 1992.
44. Alcalay M, Zangrilli D, Pandolfi PP, et al: Translocation break-point of acute promyelocytic leukemia lies within the retinoic acid receptor α locus. Proc Natl Acad Sci USA 88:1977-1981, 1991.
45. Borrow J, Goddard AD, Sheer D, et al: Molecular analysis of acute promyelocytic leukemia breakpoint. Science 249:1577-1580, 1990.
46. de The H, Chomienne C, Lanotte M, et al: The t(15;17) translocation of acute promyelocytic leukaemia. Nature 347:558-561, 1990.
47. Kamada N, Okada K, Oguma N, et al: C-G translocation in acute myelocytic leukemia with low neutrophil alkaline phosphatase activity. Cancer 37:2380-2387, 1976.
48. Sandberg AA: The Chromosomes in Human Cancer and Leukemia, New York, Elsevier Science Publishers, 1980.
49. Hurwitz CA, Raimondi SC, Head D, et al: Distinctive immunophenotypic features of t(8;21)(q22;q22) acute myeloblastic leukemia in children. Blood 80:3182-3188, 1992.
50. Tallman MS, Hakimian D, Shaw JM, et al: Granulocytic sarcoma is associated with the 8;21 translocation in acute myeloid leukemia. J Clin Oncol 11:690-697, 1993.
51. Raimondi SC, Kalwinsky DK, Hayashi Y, et al: Cytogenetics of childhood acute nonlymphocytic leukemia. Cancer Genet Cytogenet 40:13-27, 1989.
52. Berger R, Bernheim A, Daniel M-T, et al: Cytologic characterization and significance of normal karyotypes in t(8;21) acute myeloblastic leukemia. Blood 59:171-178, 1982.
53. Groupe Francais de Cytogenetique Hematologique: Acute myelogenous leukemia with an 8;21 translocation. A report on 148 cases from the Groupe Francais de Cytogenetique Hematologique. Cancer Genet Cytogenet 44:169-179, 1990.
54. Martinez-Climent JA, Lane NJ, Rubin CM, et al: Clinical and prognostic significance of chromosomal abnormalities in childhood acute myeloid leukemia de novo. Leukemia 9:95-101, 1995.
55. Erickson P, Gao J, Chang K-S, et al: Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood 80:1825-1831, 1992.
56. Roulston D, Nucifora G, Dietz-Band J, et al: Detection of rare 21q22 translocation breakpoints within the AML1 gene in myeloid neoplasms by fluorescence in situ hybridization. Blood 82:532a, 1993 (abstract).
57. Romana SP, Mauchauffe M, Le Coniat M, et al: The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 85:3662-3670, 1995.
58. Larson RA, Williams SF, Le Beau MM, et al: Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis. Blood 68:1242-1249, 1986.
59. Bernard P, Dachary D, Reiffers J, et al: Acute nonlymphocytic leukemia with marrow eosinophilia and chromosome 16 abnormality: A report of 18 cases. Leukemia 3:740-745, 1989.
60. Campbell LJ, Challis J, Fok T, et al: Chromosome 16 abnormalities associated with myeloid malignancies. Genes Chromos Cancer 3:55-61, 1991.
61. Le Beau MM, Larson RA, Bitter MA, et al: Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association. N Engl J Med 309:630-636, 1983.
62. Liu P, Tarle SA, Hajra A, et al: Fusion between transcription factor CBF-beta/PEBP2-beta and a myosin heavy chain in acute myeloid leukemia. Science 261:1041-1044, 1993.
63. Redondo JM, Pfohl JL, Hernandez-Munain C, et al: Indistinguishable nuclear factor binding to functional core sites of the T cell receptor δ and murine leukemia virus enhancers. Mol Cell Biol 12:4817-4823, 1992.
64. Nuchprayoon I, Meyers S, Scott LM, et al: PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol Cell Biol 14:5558-5568, 1994.
65. Felix CA, Hosier MR, Winick NJ, et al: ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children. Blood 85:3250-3256, 1995.
66. Corral J, Forster A, Thompson S, et al: Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation. Proc Natl Acad Sci USA 90:8538-8542, 1993.
67. Hunger SP, Tkachuk DC, Amylon MD, et al: HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities. Blood 81:3197-3203, 1993.
68. Sait SNJ, Raimondi SC, Look AT, et al: A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL gene. Genes Chromos Cancer 7:28-31, 1993.
69. Thirman MJ, Gill HJ, Burnett RC, et al: Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N Engl J Med 329:909-914, 1993.
70. Raimondi SC, Peiper SC, Kitchingman GR, et al: Childhood acute lymphoblastic leukemia with chromosomal breakpoints at 11q23. Blood 73:1627-1634, 1989.
71. Cimino G, Nakamura T, Gu Y, et al: An altered 11-kilobase transcript in leukemic cell lines with the t(4;11)(q21;q23) chromosome translocation. Cancer Res 52:33811-33813, 1992.
72. Mitelman F: Catalog of Chromosome Aberrations in Cancer, 5th ed, New York, Wiley-Liss, 1994.
73. Ludwig W-D, Bartram CR, Ritter J, et al: Ambiguous phenotypes and genotypes in 16 children with acute leukemia as characterized by multiparameter analysis. Blood 71:1518-1528, 1988.
74. Cuneo A, Ferrant Z, Michaux J-L, et al: Clinical review on features and cytogenetic patterns in adult acute myeloid leukemia with lymphoid markers. Leuk Lymphoma 9:285-291, 1993.
75. Raimondi SC, Peiper SC, Kitchingman GR, et al: Childhood acute lymphoblastic leukemia with chromosomal breakpoints at 11q23. Blood 73:1627-1634, 1989.
76. Kaneko Y, Maseki N, Takasaki NB, et al: Clinical and hematologic characteristics in acute leukemia with 11q23 translocations. Blood 67:484-491, 1986.
77. Kaneko Y, Shikano T, Maseki N, et al: Clinical characteristics of infant acute leukemia with or without 11q23 translocations. Leukemia 2:672-676, 1988.
78. Tkachuk DC, Kohler S, Cleary ML: Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71:691-700, 1992.
79. Tse W, Zhu W, Chen HS, et al: A novel gene AF1q, fused to MLL in t(1;11)(q21;q23), is specifically expressed in leukemic and immature hematopoietic cells. Blood 85:650-656, 1995.
80. Iida S, Seto M, Yamamoto K, et al: MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13. Oncogene 8:3085-3092, 1993.
81. Pui C-H, Behm FG, Raimondi SC, et al: Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia. N Engl J Med 321:136-142, 1989.
82. Smith MA, Rubinstein L, Ungerleider RS: Therapy-related acute myeloid leukemia following treatment with epipodophyllotoxins: Estimating the risks. Med Pediatr Oncol 23:86-98, 1994.
83. Sandoval C, Pui C-H, Bowman LC, et al: Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiation. J Clin Oncol 11:1039-1045, 1993.
84. Bloomfield CD, Goldman AI, Alimena G, et al: Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia. Blood 67:415-420, 1986.
85. Bloomfield CD, Secker-Walker LM, Goldman AI, et al: Six-year follow-up of the clinical significance of karyotype in acute lymphoblastic leukemia. Cancer Genet Cytogenet 40:171-185, 1989.
86. Third International Workshop on Chromosomes in Leukemia (1980): Chromosomal abnormalities in acute lymphoblastic leukemia. Cancer Genet Cytogenet 4:101-111, 1981.
87. Secker-Walker LM, Lawler SD, Hardisty RM: Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis. Br Med J 2:1529-1530, 1978.
88. Heerema NA, Palmer CG, Baehner RL: Karyotypic and clinical findings in a consecutive series of children with acute lymphocytic leukemia. Cancer Genet Cytogenet 17:165-179, 1985.
89. Secker-Walker LM, Chessells JM, Stewart EL, et al: Chromosomes and other prognostic factors in acute lymphoblastic leukaemia: A long-term follow-up. Br J Haematol 72:336-342, 1989.
90. Williams DL, Tsiatis A, Brodeur GM, et al: Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia. Blood 60:864-871, 1982.
91. Secker-Walker LM: Prognostic and biological importance of chromosome findings in acute lymphoblastic leukemia. Cancer Genet Cytogenet 49:1-13, 1990.
92. Groupe Francais de Cytogenetique Hematologique: Collaborative study of karyotypes in childhood acute lymphobblastic leukemias. Leukemia 7:10-19, 1993.
93. Raimondi SC: Current status of cytogenetic research in childhood acute lymphoblastic leukemia. Blood 81:2237-2251, 1993.
94. Pui C-H, Raimondi SC, Dodge RK, et al: Prognostic importance of structural chromosomal abnormalities in children with hyper-diploid (>50 chromosomes) acute lymphoblastic leukemia. Blood 73:1963-1967, 1989.
95. Crist W, Carroll A, Shuster J, et al: Philadelphia chromosome positive childhood acute lymphoblastic leukemia: Clinical and cytogenetic characteristics and treatment outcome. A Pediatric Oncology Group study. Blood 76:489-494, 1990.
96. Ribeiro RC, Pui C-H: Prognostic factors in childhood acute lymphoblastic leukemia. Heme Pathol 7:121-142, 1993.
97. Pui C-H, Carroll AJ, Raimondi SC, et al: Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with near-haploid or hypodiploid <45 line. Blood 75:1170-1177, 1990.
98. Brodeur GM, Williams DL, Look AT, et al: Near-haploid acute lymphoblastic leukemia: A unique subgroup with a poor prognosis? Blood 58:14-19, 1981.
99. Leder P, Battey J, Lenoir G, et al: Translocations among antibody genes in human cancer. Science 222:765-770, 1983.
100. Croce CM, Erikson J, Haluska FG, et al: Molecular genetics of human B- and T-cell neoplasia. Cold Spring Harb Symp 51:891-898, 1986.
101. Korsmeyer SJ: Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes. Ann Rev Immunol 10:785-807, 1992.
102. Cairo MS, Krailo M, Hutchinson R, et al: Results of a phase II trial of "French" (F) (LMB-86) or "Orange" (O) (CCG-Hybrid) in children with advanced non-lymphoblastic non-Hodgkin's lymphoma: an improvement in survival. Proc ASCO 13:392, 1994 (abstract).
103. Rabbitts TH: Chromosomal translocations in human cancer. Nature 372:143-149, 1994.
104. Pui C-H, Williams DL, Roberson PK, et al: Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia. J Clin Oncol 6:56-61, 1988.
105. Uckun FM, Gajl-Peczalska KJ, Provisor AL, et al: Immunophenotype-karyotype associations in human acute lymphoblastic leukemia. Blood 73:271-280, 1989.
106. Pui C-H, Behm FG, Singh B, et al: Heterogeneity of presenting features and their relation to treatment outcome in 120 children with T-cell acute lymphoblastic leukemia. Blood 75:174-179, 1990.
107. Carroll AJ, Crist WM, Link MP, et al: The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia: A Pediatric Oncology Group study. Blood 76:1220-1224, 1990.
108. Finger LR, Kagan J, Christopher G, et al: Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc Natl Acad Sci USA 86:5039-5043, 1989.
109. Begley CG, Aplan PD, Davey MP, et al: Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor δ-chain diversity region and results in a previously unreported fusion transcript. Proc Natl Acad Sci USA 86:2031-2035, 1989.
110. Bash RO, Hall S, Timmons CF, et al: Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A Pediatric Oncology Group study. Blood 86:666-676, 1995.
111. Aplan PD, Lombardi DP, Ginsberg AM, et al: Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity. Science 250:1426-1429, 1990.
112. Pui C-H, Raimondi SC, Hancock ML, et al: Immunologic, cytogenetic, and clinical characterization of childhood acute lymphoblastic leukemia with the t(1;19)(q23;p13) or its derivative. J Clin Oncol 12:2601-2606, 1994.
113. Fletcher JA, Lynch EA, Kimball VM, et al: Translocation (9;22) is associated with extremely poor prognosis in intensively treated children with acute lymphoblastic leukemia. Blood 77:435-439, 1991.
114. Kurzrock R, Gutterman JU, Talpaz M: The molecular genetics of Philadelphia chromosome-positive leukemias. N Engl J Med 319:990-998, 1988.
115. 1 -positive acute lymphocytic leukemia (ALL). Science 239:775-777, 1988.
116. Suryanarayan K, Hunger SP, Kohler S, et al: Consistent involvement of the BCR gene by 9;22 breakpoints in pediatric acute leukemias. Blood 77:324-330, 1991.
117. Pui C-H, Frankel LS, Carroll AJ, et al: Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): A collaborative study of 40 cases. Blood 77:440-447, 1991.
118. Schardt C, Ottmann OG, Hoelzer D, et al: Acute lymphoblastic leukemia with the (4;11) translocation: combined cytogenetic, immunlogical and molecular genetic analyses. Leukemia 6:370-374, 1992.
119. Heerema NA, Arthur DC, Sather H, et al: Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia: impact of the 11q23 breakoint on outcome: A report of the Childrens Cancer Group. Blood 83:2274-2284, 1994.
120. Lampert F, Harbott J, Ludwig W-D, et al: Acute leukemia with chromosome translocation (4;11): 7 new patients and analysis of 71 cases. Blut 54:325-335, 1987.
121. Gu Y, Nakamura T, Alder H, et al: The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71:701-708, 1992.
122. Domer PH, Fakharzadeh SS, Chen C-S, et al: Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. Proc Natl Acad Sci USA 90:7884-7888, 1993.
123. Morrissey J, Tkachuk DC, Milatovich A, et al: A serine/prolinerich protein is fused to HRX in t(4;11) acute leukemias. Blood 81:1124-1131, 1993.
124. Bigner SH, Mark J, Ballard DE, et al: Chromosomal evolution in malignant gliomas starts with specific and usually numerical deviations. Cancer Genet Cytogenet 22:121-135, 1986.
125. Cowan JM, Halaban R, Francke U: Cytogenetic analysis of melanocytes from premalignant nevi and melanomas. J Natl Cancer Inst 80:1159-1164, 1988.
126. Lukeis R, Irving L, Garson M: Cytogenetics of non-small cell lung cancer. Analysis of consistent non-random abnormalities. Genes Chromos Cancer 2:116-124, 1990.
127. Chilcote RR, Brown E, Rowley JD: Lymphoblastic leukemia with lymphomatous features associated with abnormalities of the short arm of chromosome 9. N Engl J Med 313:286-292, 1985.
128. Laï JL, Fenaux P, Pollet JP, et al: Acute lymphocytic leukemia with 9p anomalies. A report of four additional cases and review of the literature. Cancer Genet Cytogenet 33:99-109, 1988.
129. Carroll AJ, Castleberry RP, Crist WM: Lack of association between abnormalities of the chromosome 9 short arm and either "lymphomatous" features or T cell phenotype in childhood acute lymphocytic leukemia. Blood 69:735-738, 1987.
130. Murphy SB, Raimondi SC, Rivera GK, et al: Nonrandom abnormalities of chromosome 9p in childhood acute lymphoblastic leukemia: association with high-risk clinical features. Blood 74:409-415, 1989.
131. Kamb A, Shattuck-Eidens D, Eeles R, et al: Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus. Science 264:436-440, 1994.
132. Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366:704-707, 1993.
133. Nobori T, Miura K, Wu DJ, et al: Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368:753-756, 1994.
134. Takeuchi S, Bartram CR, Seriu T, et al: Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood. Blood 86:755-760, 1995.
135. ink4 gene inactivation in acute lymphocytic leukemia. Blood 85:3431-3436, 1995.
136. INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias. Blood 84:4038-4044, 1995.
137. Szczylik C, Sikorski T, Nicolaides NC, et al: Selective inhibition of leukemia cell proliferatin by bcr-abl antisense oligodeoxynucleotides. Science 253:562-565, 1991.